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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kpccz</journal-id><journal-title-group><journal-title xml:lang="ru">Комплексные проблемы сердечно-сосудистых заболеваний</journal-title><trans-title-group xml:lang="en"><trans-title>Complex Issues of Cardiovascular Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2306-1278</issn><issn pub-type="epub">2587-9537</issn><publisher><publisher-name>Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17802/2306-1278-2021-10-4-131-141</article-id><article-id custom-type="elpub" pub-id-type="custom">kpccz-1002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ ПРАКТИКИ. Внутренние болезни</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE STUDY. Internal medicine</subject></subj-group></article-categories><title-group><article-title>Опыт лечения пациентов с артериальными и венозными тромбозами при COVID-19: клинические наблюдения</article-title><trans-title-group xml:lang="en"><trans-title>Experience in treatment of patients with arterial and venous thrombosis with proven COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1696-618X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шпилянский</surname><given-names>Э. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Shpilyanskiy</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шпилянский Эдуард Маркович, доктор медицинских наук главный врач государственного бюджетного учреждения здравоохранения Московской области «Королёвская городская больница», Королёв, Российская Федерация; профессор кафедры общественного здоровья и здравоохранения имени Н.А. Семашко федерального государственного автономного образовательного учреждения высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)</p><p>ул. Циолковского дом 24, Королёв, 141070,</p><p>ул. Трубецкая, 8, стр. 2, Москва, 119991</p></bio><bio xml:lang="en"><p>Shpilyanskiy Eduard M., PhD, MD, Chief Physician of the State Budgetary Healthcare Institution “Korolev City Hospital”, Korolev, Russian Federation; Professor at the Department of Public Health and Healthcare named after N.A. Semashko of the Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University)</p><p>24, Tsiolkovsky St., Korolev, Moscow region, 141070,</p><p>8-2, Trubetskaya St., Moscow, 119991</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3015-9317</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ройтман</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Roitman</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ройтман Евгений Витальевич, доктор биологических наук, профессор кафедры онкологии, гематологии и лучевой терапии педиатрического факультета</p><p>ул. Островитянова, 1, Москва, 17997</p></bio><bio xml:lang="en"><p>Roitman Evgeny V., Doctor of Biological Sciences, Professor of the Department of Oncology, Hematology and Radiation Therapy of the Pediatric Faculty</p><p>1, Ostrovityanova St. Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4167-5261</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозов</surname><given-names>К. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozov</surname><given-names>K. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозов Константин Моисеевич, доктор медицинских наук врач – сердечно-сосудистый хирург</p><p>Юбилейный проспект, 6а, Химки, Российская Федерация, 141407</p></bio><bio xml:lang="en"><p>Morozov Konstantin M., MD, Cardiovascular Surgeon</p><p>6a, Yubileyniy Ave., Khimki, 141407</p></bio><email xlink:type="simple">morozovkonstantin@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0073-160X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сухарева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sukhareva</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сухарева Татьяна Викторовна, кандидат медицинских наук, врач – сердечно-сосудистый хирург хирургического отделения № 1</p><p>ул. Циолковского дом 24, Королёв, 141070</p></bio><bio xml:lang="en"><p>Sukhareva Tatiana V., PhD, Cardiovascular Surgeon of the Surgical Department No. 1</p><p>24, Tsiolkovsky St., Korolev, Moscow region, 141070</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Государственное бюджетное учреждение здравоохранения Московской области «Королёвская городская больница»;&#13;
Федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)<country>Россия</country></aff><aff xml:lang="en">State Budgetary Healthcare Institution “Korolev City Hospital”;&#13;
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University)<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное государственное автономное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Многопрофильный семейный медицинский центр «Центр медицины и реабилитации» (Premium Clinic)<country>Россия</country></aff><aff xml:lang="en">Center of Medicine and Rehabilitation (Premium Clinic)<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Государственное бюджетное учреждение здравоохранения Московской области «Королёвская городская больница»<country>Россия</country></aff><aff xml:lang="en">State Budgetary Healthcare Institution “Korolev City Hospital”<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>21</day><month>12</month><year>2021</year></pub-date><volume>10</volume><issue>4</issue><fpage>131</fpage><lpage>141</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шпилянский Э.М., Ройтман Е.В., Морозов К.М., Сухарева Т.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Шпилянский Э.М., Ройтман Е.В., Морозов К.М., Сухарева Т.В.</copyright-holder><copyright-holder xml:lang="en">Shpilyanskiy E.M., Roitman E.V., Morozov K.M., Sukhareva T.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nii-kpssz.com/jour/article/view/1002">https://www.nii-kpssz.com/jour/article/view/1002</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. COVID-19 представлен большим количеством фенотипов, варьирующих от бессимптомного течения до тяжелой полиорганной недостаточности. Механизмы развития синдрома полиорганной недостаточности имеют множество факторов, в том числе гиперкоагуляцию с образованием тромбов. Часто их диагностируют как тромботические осложнения с выявлением тромбов не только в венах и легочных артериях, но в сердце и магистральных артериях. Результаты исследования показывают, что частота венозных и артериальных тромбозов достигает 31% среди пациентов с пневмонией, вызванной COVID-19.</p></sec><sec><title>Цель</title><p>Цель. Обобщить и проанализировать клинические случаи лечения больных тромбозами и COVID-19.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включены пять больных мужского пола с тромбозами артерий и вен, а также положительным тестом на COVID-19.</p></sec><sec><title>Результаты</title><p>Результаты. У всех пациентов наблюдались характерные изменения в коагулограмме. Наибольший интерес представляет больной, у которого при поступлении был отрицательный тест на COVID-19, а значимые изменения показателей коагулограммы отмечены в день рецидива тромбоза. Все пациенты получали стандартное лечение и выписаны после улучшения состояния и отрицательным результатом теста на COVID-19.</p></sec><sec><title>Заключение</title><p>Заключение. Обобщение клинического течения больных COVID-19 и тромбозами различных сосудистых регионов позволило более подробно исследовать данный вопрос и предложить тактику лечения данных пациентов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. COVID-19 is represented by a large number of different phenotypes, ranging from asymptomatic progress to the development of severe multiple organ dysfunction syndrome. The mechanisms of development of multiple organ dysfunction syndrome are multifactorial, including hypercoagulation with the formation of blood clots. They are often diagnosed as thrombotic complications with detection of blood clots not only in the veins and pulmonary arteries, but also in the heart and main arteries. An observational study shows that the incidence of venous and arterial thrombosis is as high as 31% in patients with COVID-19 pneumonia. However, large studies have not yet been conducted.</p></sec><sec><title>Aim</title><p>Aim. To generalize and analyze our own observations of the clinical course of patients with thrombosis and COVID-19.</p></sec><sec><title>Methods</title><p>Methods. The study included 5 male patients who had arterial and venous thrombosis and COVID-19 positive test. Results The experience of treatment of 5 patients with COVID-19 with arterial and venous thrombosis was analyzed. All patients showed characteristic changes in the coagulogram. The patient who, upon admission, had a negative test for COVID-19, and characteristic changes in the coagulogram appeared on the day of recurrent thrombosis, was of greatest interest. All patients received standard treatment and were discharged with improvement after testing negative for COVID-19.</p></sec><sec><title>Conclusion</title><p>Conclusion. Generalization of the clinical course of patients with COVID-19 and thrombosis of various vascular regions allowed us to develop treatment tactics for these groups of patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>тромбоз</kwd><kwd>гемостаз</kwd><kwd>COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thrombosis</kwd><kwd>hemostasis</kwd><kwd>COVID-19</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lok FA Kruip Mjha, van der Meer Njm et al. – Trombosis reserch 2020, HTTPS://DOI.ORG/10.1016/ J. 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