kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2024-13-1-88-97kpccz-1062Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОР. КардиологияREVIEW. CardiologyПРИМЕНЕНИЕ ОМЕГА-3 ПОЛИНЕНАСЫЩЕННЫХ ЖИРНЫХ КИСЛОТ В ПРОФИЛАКТИКЕ ПОСЛЕОПЕРАЦИОННОЙ ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙ ПРИ КОРОНАРНОМ ШУНТИРОВАНИИOMEGA-3 POLYUNSATURATED FATTY ACIDS ADMINISTRATION IN PREVENTION OF POSTOPERATIVE ATRIAL FIBRILLATION DURING CORONARY ARTERY BYPASS GRAFT SURGERYhttps://orcid.org/0000-0001-9351-6177РубаненкоОлеся АнатольевнаRubanenkoOlesya A.

кандидат медицинских наук доцент кафедры госпитальной терапии с курсами поликлинической терапии и трансфузиологии федерального государственного бюджетного образовательного учреждения высшего образования «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Самара, Российская Федерация

PhD, Associate Professor at the Department of Advanced Therapy incorporating courses of Polyclinic Therapy and Transfusion Medicine, Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University” of the Ministry of Health of the Russian Federation, Samara, Russian Federation

olesya.rubanenko@gmail.comhttps://orcid.org/0000-0002-3996-4689РубаненкоАнатолий ОлеговичRubanenkoAnatoly O.

кандидат медицинских наук доцент кафедры пропедевтической терапии федерального государственного бюджетного образовательного учреждения высшего образования «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Самара, Российская Федерация

PhD, Associate Professor at the Department of Propaedeutics, Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University” of the Ministry of Health of the Russian Federation, Samara, Russian Federation

anatolii.rubanenko@gmail.comФедеральное государственное бюджетное образовательное учреждение высшего образования «Самарский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education “Samara State Medical University” of the Ministry of Healthcare of the Russian FederationRussian Federation2024290320241318897Copyright © Рубаненко О.А., Рубаненко А.О., 20242024Рубаненко О.А., Рубаненко А.О.Rubanenko O.A., Rubanenko A.O.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/1062Основные положения

Основные положения

Назначение омега-3 полиненасыщенных жирных кислот для профилактики послеоперационной фибрилляции предсердий при проведении коронарного шунтирования у пациентов с ишемической болезнью сердца требует тщательного анализа характеристики выборки больных с оценкой клинических, эхокардиографических параметров, факторов оперативного вмешательства, показателей воспаления, окислительного стресса. Кроме того, дозировка препарата и длительность его применения определяют влияние на риск возникновения фибрилляции предсердий. Омега-3 полиненасыщенные жирные кислоты в краткосрочной терапии уменьшают частоту новых эпизодов указанной аритмии после коронарного вмешательства, однако данное влияние нивелируется совместным применением статинов.

 

 

Резюме

Резюме

В статье представлены данные литературы об эффективности применения омега-3 полиненасыщенных жирных кислот в профилактике послеоперационной фибрилляции предсердий у пациентов с ишемической болезнью сердца при проведении коронарного шунтирования. Освещены возможные механизмы антиаритмического действия препарата, включая его противовоспалительный и антиоксидантный эффекты. Обсуждаются причины снижения активности омега-3 полиненасыщенных жирных кислот при комбинированном назначении с ингибиторами ГМГ-КоА-редуктазы.

Highlights

Highlights

The appointment of omega-3 polyunsaturated fatty acids for the prevention of postoperative atrial fibrillation during coronary artery bypass grafting in patients with coronary artery disease requires a thorough analysis of the characteristics of a patient and an assessment of clinical and echocardiographic parameters, factors influencing surgical performance, inflammation, and oxidative stress. Moreover, the dosage of the drug impacts the risk of atrial fibrillation. Omega-3 polyunsaturated fatty acids in short-term therapy reduce the frequency of new episodes of this arrhythmia after the intervention, however, this effect is offset by the combined use of statins.

 

 

Abstract

Abstract

The article presents the available literature data on the effectiveness of the use of omega-3 polyunsaturated fatty acids in the prevention of postoperative atrial fibrillation in patients with coronary artery disease during coronary artery bypass grafting. Possible mechanisms of the drug’s antiarrhythmic action are highlighted, including its anti-inflammatory and antioxidant effects. The reasons for the decrease in the activity of omega-3 polyunsaturated fatty acids in combination with HMG-CoA reductase inhibitors are discussed.

Омега-3 полиненасыщенные жирные кислотыФибрилляция предсердийКоронарное шунтированиеOmega-3 polyunsaturated fatty acidsAtrial fibrillationCoronary artery bypass graftingАвторы заявляют об отсутствии финансирования исследования.ReferencesTribulova N., Szeiffova Bacova B., Egan Benova T., Knezl V., Barancik M., Slezak J. Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs. Nutrients. 2017;9(11):1191; doi: 10.3390/nu9111191.Tribulova N, Bacova BS, Benova TE, et al. Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs. Nutrients. 2017;9(11):1191; doi: 10.3390/nu9111191.Golpour P., Nourbakhsh M., Mazaherioun M., Janani L., Nourbakhsh M., Yaghmaei P. Improvement of NRF2 gene expression and antioxidant status in patients with type 2 diabetes mellitus after supplementation with omega-3 polyunsaturated fatty acids: A double-blind randomised placebo-controlled clinical trial. 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The authors declare that there are no conflicts of interest present.