kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2022-11-2-107-115kpccz-1077Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОР. Сердечно-сосудистая хирургияREVIEWS. Cardiovascular surgeryВлияние шунтируемых коронарных артерий на кондуитыThe influence of grafted coronary arteries on vascular conduitshttps://orcid.org/0000-0002-1746-8895ФроловА. В.FrolovA. V.

Фролов Алексей Витальевич, кандидат медицинских наук старший научный сотрудник лаборатории рентгенэндоваскулярной и реконструктивной хирургии сердца и сосудов отдела хирургии сердца и сосудов, врач – сердечно-сосудистый хирург отделения кардиохирургии № 1

Сосновый бульвар, 6, Кемерово, 650002

Frolov Alexey V., MD, PhD, Senior Researcher at the Laboratory of Interventional and Reconstructive Cardiovascular Surgery, Cardiovascular Surgeon

6, Sosnoviy blvd, Kemerovo, 650002

kjerne@yandex.ruФедеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияFederal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”Russian Federation202211052022112107115Copyright © Фролов А.В., 20222022Фролов А.В.Frolov A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/1077

В настоящее время в коронарной хирургии успешно используют два вида сосудистых кондуита – венозные и артериальные. Известно, что последние имеют больше преимуществ. Для объяснения природы взаимодействия между выбранным кондуитом и целевой коронарной артерией (КА) предложена концепция системы «кондуит – артерия», которая также призвана помочь клиницистам в выборе сосудистого трансплантата для коронарного шунтирования. Предполагается, что система состоит из двух составляющих. Первая часть представлена в виде выбранного кондуита и его влияния на КА. Данный факт подтвержден результатами нескольких важных исследований, которые, например, показали, что внутренняя грудная артерия обладает кардиопротективными свойствами. Последняя может секретировать такие вазоактивные субстанции, как оксид азота, простациклин, эндотелиальный гиперполяризующий фактор и другие. Вторая часть предложенной системы – КА, оказываемое ею воздействие и возможное распространение атеросклероза с вовлечением используемых шунтов за счет особых механизмов. В силу минимальной изученности последнего влияния мы предприняли попытку осветить данный вопрос в рамках литературного обзора. 

Both arterial and venous conduits can be used for coronary bypass surgery. Arterial conduits have more advantages over venous conduits. The concept of “graft-artery junction” was created to help specialists understand the complex interaction between the chosen conduit and target coronary vessel, and assist clinicians in choosing the appropriate vascular conduit for coronary artery bypass grafting. Supposedly, the system is comprised of two parts. The first part is represented by the chosen conduit and its influence on coronary arteries. The existence of such influence has been proven by previous studies, some of which indicated that internal mammary artery has cardioprotective effects. Artery walls secrete such vasoactive substances as nitric oxide, prostacyclin, endothelial hyperpolarized factor, etc. The second part is represented by coronary arteries, their influence and specific mechanisms of atherosclerosis spreading (involving grafts). The number of studies devoted to this topic remains low, therefore, we have attempted to highlight this issue within this review.

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The authors declare that there are no conflicts of interest present.