kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2024-13-3-111-117kpccz-1092Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОР. Патологическая физиологияREVIEWS. Pathological physiologyРОЛЬ ГРЕБЕНЧАТЫХ МЫШЦ В ФОРМИРОВАНИИ УСЛОВИЙ ГЕМОДИНАМИКИ В ПОЛОСТЯХ СЕРДЦА ЧЕЛОВЕКАROLE OF PECTINATE MUSCLES IN HEMODYNAMICS IN THE CAVITIES OF THE HUMAN HEARThttps://orcid.org/0000-0002-8552-6727МилюковВладимир ЕфимовичMilyukovVladimir E.

доктор медицинских наук, профессор и. о. заведующего кафедрой топографической анатомии и оперативной хирургии федерального государственного автономного образовательного учреждения высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской Федерации, Москва, Российская Федерация

PhD, Professor, Acting Head of the Department of Topographic Anatomy and Operative Surgery, Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation, Moscow, Russian Federation

Milyucov@mail.ruhttps://orcid.org/0000-0001-8445-3688БрюхановВалерий АлександровичBryukhanovValery A.

студент Международной школы «Медицина будущего» федерального государственного автономного образовательного учреждения высшего образования Первый Московский государственный медицинский университет имени И. М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет), Москва, Российская Федерация

student, International School “Medicine of the Future” of the Federal State Autonomous Educational Institution of Higher Education “I.M. Sechenov First Moscow State Medical University” of the Ministry of Health of the Russian Federation, Moscow, Russian Federation

bryuhanov02@mail.ruhttps://orcid.org/0000-0003-3966-0738ШарифоваХеяля Муршуд КызыSharifovaHeyala Murshud kyzy

кандидат медицинских наук старший преподаватель кафедры анатомии человека федерального государственного автономного образовательного учреждения высшего образования Первый Московский государственный медицинский университет имени И. М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет), Москва, Российская Федерация

PhD, Senior Lecturer at the Department of Human Anatomy, Federal State Autonomous Educational Institution of Higher Education “I.M. Sechenov First Moscow State Medical University” of the Ministry of Health of the Russian Federation, Moscow, Russian Federation

murshudova.kh@yandex.ruhttps://orcid.org/0000-0003-2190-6648НгуенКао КыонгNguyenCao Cuong

кандидат медицинских наук декан факультета фармако-медсестринского дела Университета им. Йерсена, Далат, Вьетнам

PhD, Dean of the Faculty of Pharmacy and Nursing, Yersin University of Da Lat of Vietnam, Da Lat, Vietnam

nguyencaocuong2712@gmail.comФедеральное государственное автономное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской ФедерацииРоссияFederal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian FederationRussian FederationФедеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И. М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Russian FederationУниверситет им. ЙерсенаВьетнамYersin university of Da Lat of Viet NamViet Nam202430092024133111117Copyright © Милюков В.Е., Брюханов В.А., Шарифова Х.М., Нгуен К.К., 20242024Милюков В.Е., Брюханов В.А., Шарифова Х.М., Нгуен К.К.Milyukov V.E., Bryukhanov V.A., Sharifova H.M., Nguyen C.C.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/1092Основные положения

Основные положения

Настоящий обзор предваряет планируемое исследование и представляет собой критический анализ доступных в литературе научных работ, посвященных роли гребенчатых мышц в формировании морфофункциональных условий организации внутриполостной гемодинамики в сердце.

 

 

Резюме

Резюме

В обзоре проанализированы современные публикации по оценке функциональной роли гребенчатых мышц в организации условий движения крови в предсердиях. На основе данного анализа определен ряд вопросов для дальнейших исследований, ответы на которые будут способствовать разработке новых диагностических систем и критериев в кардиологии, а также созданию анатомо-физиологически обоснованных протезов клапанов в кардиохирургии с учетом индивидуальных гидродинамических закономерностей кровотока.

Highlights

Highlights

This review precedes the planned study and is an analysis of the available works on the role of pectinate muscles in the development of morphological and functional conditions of intracavitary hemodynamics in the heart.

 

 

Abstract

Abstract

This review presents an analysis of recent publications on the assessment of the functional role of the pectinate muscles in the development of morphological and functional conditions of blood flow in the atria. The results of this analysis helped us to identify a number of topics for further research. The results of this research should help us develop new diagnostic systems and criteria in cardiology field, and assist in furthering research regarding the development of anatomically and physiologically substantiated valve prostheses, taking into account the individual characteristics of the hydrodynamic patterns of blood flow.

Гребенчатые мышцыГемодинамикаЗакрученный поток кровиУшко левого предсердияPectinate musclesHemodynamicsSwirling blood flowLeft atrial appendageАвторы заявляют об отсутствии финансирования исследования.ReferencesHindricks G., Potpara T., Dagres N., Arbelo E., Bax J.J., Blomström-Lundqvist C., Boriani G., Castella M., Dan G.A., Dilaveris P.E., Fauchier L., Filippatos G., Kalman J.M., La Meir M., Lane D.A., Lebeau J.P., Lettino M., Lip G.Y.H., Pinto F.J., Thomas G.N., Valgimigli M., Van Gelder I.C., Van Putte B.P., Watkins C.L.; ESC Scientific Document Group. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373-498. doi:10.1093/eurheartj/ehaa612Hindricks G., Potpara T., Dagres N., Arbelo E., Bax J.J., Blomström-Lundqvist C., Boriani G., Castella M., Dan G.A., Dilaveris P.E., Fauchier L., Filippatos G., Kalman J.M., La Meir M., Lane D.A., Lebeau J.P., Lettino M., Lip G.Y.H., Pinto F.J., Thomas G.N., Valgimigli M., Van Gelder I.C., Van Putte B.P., Watkins C.L.; ESC Scientific Document Group. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373-498. doi:10.1093/eurheartj/ehaa612Best, J. G., Bell, R., Haque, M., Chandratheva, A., Werring, D. J. Atrial fibrillation and stroke: a practical guide. Pract Neurol. 2019;19(3):208-224. doi:10.1136/practneurol-2018-002089Best, J. G., Bell, R., Haque, M., Chandratheva, A., Werring, D. J. Atrial fibrillation and stroke: a practical guide. Pract Neurol. 2019;19(3):208-224. doi:10.1136/practneurol-2018-002089Jame, S., Barnes, G. Stroke and thromboembolism prevention in atrial fibrillation. Heart. 2020;106(1):10-17. doi:10.1136/heartjnl-2019-314898Jame, S., Barnes, G. Stroke and thromboembolism prevention in atrial fibrillation. Heart. 2020;106(1):10-17. doi:10.1136/heartjnl-2019-314898Yiin G.S.C., Li L., Bejot Y., Rothwell P.M. Time Trends in Atrial Fibrillation-Associated Stroke and Premorbid Anticoagulation: Population-Based Study and Systematic Review. Stroke. 2019;50(1):21-27. doi: 10.1161/STROKEAHA.118.022249.Yiin G.S.C., Li L., Bejot Y., Rothwell P.M. Time Trends in Atrial Fibrillation-Associated Stroke and Premorbid Anticoagulation: Population-Based Study and Systematic Review. Stroke. 2019;50(1):21-27. doi: 10.1161/STROKEAHA.118.022249.Di L., Natale A., Romero J.. Thrombogenic and Arrhythmogenic Roles of the Left Atrial Appendage in Atrial Fibrillation. Circulation. 2018;138(18):2036-2050. doi:10.1161/CIRCULATIONAHA.118.034187Di L., Natale A., Romero J.. Thrombogenic and Arrhythmogenic Roles of the Left Atrial Appendage in Atrial Fibrillation. Circulation. 2018;138(18):2036-2050. doi:10.1161/CIRCULATIONAHA.118.034187Cresti A., García-Fernández M.A., Sievert H., Mazzone P., Baratta P., Solari M., Geyer A., De Sensi F., Limbruno U. Prevalence of extra-appendage thrombosis in non-valvular atrial fibrillation and atrial flutter in patients undergoing cardioversion: a large transoesophageal echo study. EuroIntervention. 2019;15(3):e225-e230. doi:10.4244/EIJ-D-19-00128Cresti A., García-Fernández M.A., Sievert H., Mazzone P., Baratta P., Solari M., Geyer A., De Sensi F., Limbruno U. Prevalence of extra-appendage thrombosis in non-valvular atrial fibrillation and atrial flutter in patients undergoing cardioversion: a large transoesophageal echo study. EuroIntervention. 2019;15(3):e225-e230. doi:10.4244/EIJ-D-19-00128Bazira P.J. Clinically applied anatomy of the heart. Surgery (Oxford). 2021; 39(3):117-125. doi:10.1016/j.mpsur.2021.01.004Bazira P.J. Clinically applied anatomy of the heart. Surgery (Oxford). 2021; 39(3):117-125. doi:10.1016/j.mpsur.2021.01.004Ueda A., McCarthy K.P., Sánchez-Quintana D., Ho S.Y. Right atrial appendage and vestibule: further anatomical insights with implications for invasive electrophysiology. Europace. 2013;15(5):728-34. doi:10.1093/europace/eus382Ueda A., McCarthy K.P., Sánchez-Quintana D., Ho S.Y. Right atrial appendage and vestibule: further anatomical insights with implications for invasive electrophysiology. Europace. 2013;15(5):728-34. doi:10.1093/europace/eus382Hensey M., O'Neill L., Mahon C., Keane S., Fabre A., Keane D. A Review of the Anatomical and Histological Attributes of the Left Atrial Appendage with Descriptive Pathological Examination of Morphology and Histology. J Atr Fibrillation. 2018;10(6):1650. doi:10.4022/jafib.1650Hensey M., O'Neill L., Mahon C., Keane S., Fabre A., Keane D. A Review of the Anatomical and Histological Attributes of the Left Atrial Appendage with Descriptive Pathological Examination of Morphology and Histology. J Atr Fibrillation. 2018;10(6):1650. doi:10.4022/jafib.1650Beigel R., Wunderlich N.C., Ho S.Y., Arsanjani R., Siegel R.J. The left atrial appendage: anatomy, function, and noninvasive evaluation. JACC Cardiovasc Imaging. 2014;7(12):1251-65. doi:10.1016/j.jcmg.2014.08.009Beigel R., Wunderlich N.C., Ho S.Y., Arsanjani R., Siegel R.J. The left atrial appendage: anatomy, function, and noninvasive evaluation. JACC Cardiovasc Imaging. 2014;7(12):1251-65. doi:10.1016/j.jcmg.2014.08.009Stepanchuk A. P., Royko N. V., Fylenko B. M., Pryshlyak A. M. Morphofunctional purpose of human atrial auricles. World of medicine and biology. 2018;14(3):185-189. doi 10.26724/2079-8334-2018-3-65-185-189.Stepanchuk A. P., Royko N. V., Fylenko B. M., Pryshlyak A. M. Morphofunctional purpose of human atrial auricles. World of medicine and biology. 2018;14(3):185-189. doi 10.26724/2079-8334-2018-3-65-185-189.Ding W.Y., Gupta D., Lip G.Y.H. Atrial fibrillation and the prothrombotic state: revisiting Virchow’s triad in 2020. Heart . 2020t;106(19):1463-1468. doi:10.1136/heartjnl-2020-316977Ding W.Y., Gupta D., Lip G.Y.H. Atrial fibrillation and the prothrombotic state: revisiting Virchow’s triad in 2020. Heart . 2020t;106(19):1463-1468. doi:10.1136/heartjnl-2020-316977Khe A., Vanina V., Cherevko A., Parshin D., Chebotnikov A., Chupakhin A., Boiko A., Tulupov A. 4D MR flowmetry of vortical fluid flows in elastic tubes. In Fomin, editor, 19th International Conference on the Methods of Aerophysical Research, ICMAR. 2018;2027. American Institute of Physics Inc. 2018. 030123. (AIP Conference Proceedings). doi: 10.1063/1.5065217.Khe A., Vanina V., Cherevko A., Parshin D., Chebotnikov A., Chupakhin A., Boiko A., Tulupov A. 4D MR flowmetry of vortical fluid flows in elastic tubes. In Fomin, editor, 19th International Conference on the Methods of Aerophysical Research, ICMAR. 2018;2027. American Institute of Physics Inc. 2018. 030123. (AIP Conference Proceedings). doi: 10.1063/1.5065217.Thomas B., Sumam,K. S. Blood Flow in Human Arterial System-A Review. Procedia Technology. 2016;24:339–346. doi:10.1016/j.protcy.2016.05.045Thomas B., Sumam,K. S. Blood Flow in Human Arterial System-A Review. Procedia Technology. 2016;24:339–346. doi:10.1016/j.protcy.2016.05.045Baysan O., Ocakli E. P., Saglam Ya., Altuner T. K. Advances in echocardiography: global longitudinal strain, intra-cardiac multidirectional flow imaging and automated 3d volume analysis. Heart, Vessels and Transplantation. 2018; 2(4):113-122. doi: 10.24969/hvt.2018.83.Baysan O., Ocakli E. P., Saglam Ya., Altuner T. K. Advances in echocardiography: global longitudinal strain, intra-cardiac multidirectional flow imaging and automated 3d volume analysis. Heart, Vessels and Transplantation. 2018; 2(4):113-122. doi: 10.24969/hvt.2018.83.Li Y., Shi G., Du J., Wang J., Bian P. Analysis and preparation of rotational flow mechanism of artificial blood vessel with spiral folds on inner wall. Biomech Model Mechanobiol. 2019;18(2):411-423. doi:10.1007/s10237-018-1092-xLi Y., Shi G., Du J., Wang J., Bian P. Analysis and preparation of rotational flow mechanism of artificial blood vessel with spiral folds on inner wall. Biomech Model Mechanobiol. 2019;18(2):411-423. doi:10.1007/s10237-018-1092-xDemirkiran A., Hassell M.E.C.J., Garg P., Elbaz M.S.M., Delewi R., Greenwood J.P., Piek J.J., Plein S., van der Geest R.J., Nijveldt R. Left ventricular four-dimensional blood flow distribution, energetics, and vorticity in chronic myocardial infarction patients with/without left ventricular thrombus. Eur J Radiol. 2022;150:110233. doi: 10.1016/j.ejrad.2022.110233.Demirkiran A., Hassell M.E.C.J., Garg P., Elbaz M.S.M., Delewi R., Greenwood J.P., Piek J.J., Plein S., van der Geest R.J., Nijveldt R. Left ventricular four-dimensional blood flow distribution, energetics, and vorticity in chronic myocardial infarction patients with/without left ventricular thrombus. Eur J Radiol. 2022;150:110233. doi: 10.1016/j.ejrad.2022.110233.Kilner P. J., Yang G.-Z., Wilkes A. J., Mohiaddin R. H., Firmin D. N., Yacoub M. H. Asymmetric redirection of flow through the heart. Nature. 2000;404(6779):759–761. doi:10.1038/35008075Kilner P. J., Yang G.-Z., Wilkes A. J., Mohiaddin R. H., Firmin D. N., Yacoub M. H. Asymmetric redirection of flow through the heart. Nature. 2000;404(6779):759–761. doi:10.1038/35008075Callaghan F. M., Arnott C., Figtree G. A., Kutty S., Celermajer D. S., Grieve S. M. Quantifying right atrial filling and emptying: A 4D-flow MRI study. J Magn Reson Imaging. 2017;45(4):1046-1054. doi:10.1002/jmri.25457Callaghan F. M., Arnott C., Figtree G. A., Kutty S., Celermajer D. S., Grieve S. M. Quantifying right atrial filling and emptying: A 4D-flow MRI study. J Magn Reson Imaging. 2017;45(4):1046-1054. doi:10.1002/jmri.25457Gaeta S., Dyverfeldt P., Eriksson J., Carlhäll C.-J., Ebbers T., Bolger A. F. Fixed volume particle trace emission for the analysis of left atrial blood flow using 4D Flow MRI. Magn Reson Imaging. 2018;47:83-88. doi:10.1016/j.mri.2017.12.008Gaeta S., Dyverfeldt P., Eriksson J., Carlhäll C.-J., Ebbers T., Bolger A. F. Fixed volume particle trace emission for the analysis of left atrial blood flow using 4D Flow MRI. Magn Reson Imaging. 2018;47:83-88. doi:10.1016/j.mri.2017.12.008Suwa K., Saitoh T., Takehara Y., Sano M., Nobuhara M., Saotome M., Urushida T., Katoh H., Satoh H., Sugiyama M., Wakayama T., Alley M., Sakahara H., Hayashi H. Characteristics of intra-left atrial flow dynamics and factors affecting formation of the vortex flow – analysis with phase-resolved 3-dimensional cine phase contrast magnetic resonance imaging. Circ J. 2015;79(1):144-52. doi:10.1253/circj.CJ-14-0562Suwa K., Saitoh T., Takehara Y., Sano M., Nobuhara M., Saotome M., Urushida T., Katoh H., Satoh H., Sugiyama M., Wakayama T., Alley M., Sakahara H., Hayashi H. Characteristics of intra-left atrial flow dynamics and factors affecting formation of the vortex flow – analysis with phase-resolved 3-dimensional cine phase contrast magnetic resonance imaging. Circ J. 2015;79(1):144-52. doi:10.1253/circj.CJ-14-0562Beigel, R., Wunderlich, N. C., Ho, S. Y., Arsanjani, R., Siegel, R. J. The Left Atrial Appendage: Anatomy, Function, and Noninvasive Evaluation. JACC Cardiovasc Imaging. 2014;7(12):1251-65. doi:10.1016/j.jcmg.2014.08.009Beigel, R., Wunderlich, N. C., Ho, S. Y., Arsanjani, R., Siegel, R. J. The Left Atrial Appendage: Anatomy, Function, and Noninvasive Evaluation. JACC Cardiovasc Imaging. 2014;7(12):1251-65. doi:10.1016/j.jcmg.2014.08.009Kim Y. G., Shim J., Oh S.-K., Lee K.-N., Choi J.-I., Kim Y.-H. Electrical isolation of the left atrial appendage increases the risk of ischemic stroke and transient ischemic attack regardless of postisolation flow velocity. Heart Rhythm. 2018;15(12):1746–1753. doi:10.1016/j.hrthm.2018.09.012Kim Y. G., Shim J., Oh S.-K., Lee K.-N., Choi J.-I., Kim Y.-H. Electrical isolation of the left atrial appendage increases the risk of ischemic stroke and transient ischemic attack regardless of postisolation flow velocity. Heart Rhythm. 2018;15(12):1746–1753. doi:10.1016/j.hrthm.2018.09.012Domínguez H., Madsen C. V., Westh O. N. H., Pallesen P. A., Carrranza C. L., Irmukhamedov A., Park-Hansen J. Does Left Atrial Appendage Amputation During Routine Cardiac Surgery Reduce Future Atrial Fibrillation and Stroke? Current Cardiology Reports. 2018; 20(10): doi:10.1007/s11886-018-1033-4Domínguez H., Madsen C. V., Westh O. N. H., Pallesen P. A., Carrranza C. L., Irmukhamedov A., Park-Hansen J. Does Left Atrial Appendage Amputation During Routine Cardiac Surgery Reduce Future Atrial Fibrillation and Stroke? Current Cardiology Reports. 2018; 20(10): doi:10.1007/s11886-018-1033-4Patti G., Pengo V., Marcucci R., Cirillo P., Renda G., Santilli F., Calabrò P., De Caterina A.R., Cavallari I., Ricottini E., Parato V.M., Zoppellaro G., Di Gioia G., Sedati P., Cicchitti V., Davì G., Golia E., Pariggiano I., Simeone P., Abbate R., Prisco D., Zimarino M., Sofi F., Andreotti F., De Caterina R.; Working Group of Thrombosis of the Italian Society of Cardiology. The left atrial appendage: from embryology to prevention of thromboembolism. Eur Heart J. 2017;38(12):877-887. doi:10.1093/eurheartj/ehw159Patti G., Pengo V., Marcucci R., Cirillo P., Renda G., Santilli F., Calabrò P., De Caterina A.R., Cavallari I., Ricottini E., Parato V.M., Zoppellaro G., Di Gioia G., Sedati P., Cicchitti V., Davì G., Golia E., Pariggiano I., Simeone P., Abbate R., Prisco D., Zimarino M., Sofi F., Andreotti F., De Caterina R.; Working Group of Thrombosis of the Italian Society of Cardiology. The left atrial appendage: from embryology to prevention of thromboembolism. Eur Heart J. 2017;38(12):877-887. doi:10.1093/eurheartj/ehw159Zhang L. T., Gay M. Characterizing left atrial appendage functions in sinus rhythm and atrial fibrillation using computational models. Journal of Biomechanics. 2008;41(11):2515–2523. doi:10.1016/j.jbiomech.2008.05.01Zhang L. T., Gay M. Characterizing left atrial appendage functions in sinus rhythm and atrial fibrillation using computational models. Journal of Biomechanics. 2008;41(11):2515–2523. doi:10.1016/j.jbiomech.2008.05.01Agafonov A.V., Talygin E.A., Bockeria L.A., Gorodkov A.Y. The Hydrodynamics of a Swirling Blood Flow in the Left Heart and Aorta. Acta Naturae. 2021;13(4):4-16.doi:10.32607/actanaturae.11439Agafonov A.V., Talygin E.A., Bockeria L.A., Gorodkov A.Y. The Hydrodynamics of a Swirling Blood Flow in the Left Heart and Aorta. Acta Naturae. 2021;13(4):4-16.doi:10.32607/actanaturae.11439Ptaszynska-Kopczynska K., Kiluk I., Sobkowicz B. Atrial Fibrillation in Patients with Acute Pulmonary Embolism: Clinical Significance and Impact on Prognosis. Biomed Res Int. 2019;2019:7846291., doi:10.1155/2019/7846291Ptaszynska-Kopczynska K., Kiluk I., Sobkowicz B. Atrial Fibrillation in Patients with Acute Pulmonary Embolism: Clinical Significance and Impact on Prognosis. Biomed Res Int. 2019;2019:7846291., doi:10.1155/2019/7846291Naksuk N., Padmanabhan D., Yogeswaran V., Asirvatham S. J. Left Atrial Appendage. JACC: Clinical Electrophysiology. 2016;2(4): 403–412. doi:10.1016/j.jacep.2016.06.006Naksuk N., Padmanabhan D., Yogeswaran V., Asirvatham S. J. Left Atrial Appendage. JACC: Clinical Electrophysiology. 2016;2(4): 403–412. doi:10.1016/j.jacep.2016.06.006Richardson A.C,. Omar M., Velarde G., Missov E., Percy R., Sattiraju S. Right Atrial Appendage Thrombus in Atrial Fibrillation: A Case Report and Review of the Literature. J Investig Med High Impact Case Rep. 2021;9:23247096211010048. doi:10.1177/23247096211010048Richardson A.C,. Omar M., Velarde G., Missov E., Percy R., Sattiraju S. Right Atrial Appendage Thrombus in Atrial Fibrillation: A Case Report and Review of the Literature. J Investig Med High Impact Case Rep. 2021;9:23247096211010048. doi:10.1177/23247096211010048Yamamoto M., Seo Y., Kawamatsu N., Sato K., Sugano A., Machino-Ohtsuka T., Kawamura R., Nakajima H., Igarashi M, Sekiguchi Y, Ishizu T, Aonuma K. Complex left atrial appendage morphology and left atrial appendage thrombus formation in patients with atrial fibrillation. Circ Cardiovasc Imaging. 2014;7(2):337-43. doi:10.1161/CIRCIMAGING.113.001317Yamamoto M., Seo Y., Kawamatsu N., Sato K., Sugano A., Machino-Ohtsuka T., Kawamura R., Nakajima H., Igarashi M, Sekiguchi Y, Ishizu T, Aonuma K. Complex left atrial appendage morphology and left atrial appendage thrombus formation in patients with atrial fibrillation. Circ Cardiovasc Imaging. 2014;7(2):337-43. doi:10.1161/CIRCIMAGING.113.001317Shinoda K., Hayashi S., Fukuoka D., Torii R., Watanabe T., Nakano T. Structural Comparison between the Right and Left Atrial Appendages Using Multidetector Computed Tomography. Biomed Res Int. 2016;2016:6492183. doi:10.1155/2016/6492183Shinoda K., Hayashi S., Fukuoka D., Torii R., Watanabe T., Nakano T. Structural Comparison between the Right and Left Atrial Appendages Using Multidetector Computed Tomography. Biomed Res Int. 2016;2016:6492183. doi:10.1155/2016/6492183Koizumi R., Funamoto K., Hayase T., Kanke Y., Shibata M., Shiraishi Y., Yambe T. Numerical analysis of hemodynamic changes in the left atrium due to atrial fibrillation. Journal of Biomechanics. 2015; 48(3):472–478. doi:10.1016/j.jbiomech.2014.12.02Koizumi R., Funamoto K., Hayase T., Kanke Y., Shibata M., Shiraishi Y., Yambe T. Numerical analysis of hemodynamic changes in the left atrium due to atrial fibrillation. Journal of Biomechanics. 2015; 48(3):472–478. doi:10.1016/j.jbiomech.2014.12.02Yildirim T., Akin F., Avci E., Altun I., Yildirim S. E., Soylu M. O. Paroxysmal Atrial Fibrillation and Stroke. The American Journal of Cardiology. 2018;121(8): e42. doi:10.1016/j.amjcard.2018.03.119Yildirim T., Akin F., Avci E., Altun I., Yildirim S. E., Soylu M. O. Paroxysmal Atrial Fibrillation and Stroke. The American Journal of Cardiology. 2018;121(8): e42. doi:10.1016/j.amjcard.2018.03.119Whiteman S., Saker E., Courant V., Salandy S., Gielecki J., Zurada A., Loukas M. An anatomical review of the left atrium. Translational Research in Anatomy. 2019;17:100052. doi:10.1016/j.tria.2019.100052.Whiteman S., Saker E., Courant V., Salandy S., Gielecki J., Zurada A., Loukas M. An anatomical review of the left atrium. Translational Research in Anatomy. 2019;17:100052. doi:10.1016/j.tria.2019.100052.Garcia J., Sheitt H., Bristow M.S., Lydell C., Howarth A.G., Heydari B., Prato F.S., Drangova M., Thornhill R.E., Nery P., Wilton S.B., Skanes A., White J.A. Left atrial vortex size and velocity distributions by 4D flow MRI in patients with paroxysmal atrial fibrillation: Associations with age and CHA2 DS2 -VASc risk score. J Magn Reson Imaging. 2020;51(3):871-884.doi:10.1002/jmri.26876Garcia J., Sheitt H., Bristow M.S., Lydell C., Howarth A.G., Heydari B., Prato F.S., Drangova M., Thornhill R.E., Nery P., Wilton S.B., Skanes A., White J.A. Left atrial vortex size and velocity distributions by 4D flow MRI in patients with paroxysmal atrial fibrillation: Associations with age and CHA2 DS2 -VASc risk score. J Magn Reson Imaging. 2020;51(3):871-884.doi:10.1002/jmri.26876Di Biase L., Santangeli P., Anselmino M., Mohanty P., Salvetti I., Gili S., Horton R., Sanchez J.E., Bai R., Mohanty S., Pump A., Cereceda Brantes M., Gallinghouse G.J., Burkhardt J.D., Cesarani F., Scaglione M., Natale A., Gaita F. Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study. J Am Coll Cardiol. 2012;60(6):531-8. doi:10.1016/j.jacc.2012.04.032Di Biase L., Santangeli P., Anselmino M., Mohanty P., Salvetti I., Gili S., Horton R., Sanchez J.E., Bai R., Mohanty S., Pump A., Cereceda Brantes M., Gallinghouse G.J., Burkhardt J.D., Cesarani F., Scaglione M., Natale A., Gaita F. Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study. J Am Coll Cardiol. 2012;60(6):531-8. doi:10.1016/j.jacc.2012.04.032He J., Fu Z., Yang L., Liu W., Tian Y., Liu Q., Jiang Z., Tian L., Huang J., Tian S., Zhao Y. The predictive value of a concise classification of left atrial appendage morphology to thrombosis in non-valvular atrial fibrillation patients. Clin Cardiol. 2020;43(7):789-795. doi:10.1002/clc.23381He J., Fu Z., Yang L., Liu W., Tian Y., Liu Q., Jiang Z., Tian L., Huang J., Tian S., Zhao Y. The predictive value of a concise classification of left atrial appendage morphology to thrombosis in non-valvular atrial fibrillation patients. Clin Cardiol. 2020;43(7):789-795. doi:10.1002/clc.23381Bosi G.M., Cook A., Rai R., Menezes L.J., Schievano S., Torii R., Burriesci G. Burriesci. Computational Fluid Dynamic Analysis of the Left Atrial Appendage to Predict Thrombosis Risk. Front Cardiovasc Med. 2018;5:34. doi:10.3389/fcvm.2018.00034Bosi G.M., Cook A., Rai R., Menezes L.J., Schievano S., Torii R., Burriesci G. Burriesci. Computational Fluid Dynamic Analysis of the Left Atrial Appendage to Predict Thrombosis Risk. Front Cardiovasc Med. 2018;5:34. doi:10.3389/fcvm.2018.00034Khurram I.M., Dewire J., Mager M., Maqbool F., Zimmerman S.L., Zipunnikov V., Beinart R., Marine J.E., Spragg D.D., Berger R.D., Ashikaga H., Nazarian S., Calkins H. Relationship between left atrial appendage morphology and stroke in patients with atrial fibrillation. Heart Rhythm. 2013;10(12):1843-9.doi:10.1016/j.hrthm.2013.09.065Khurram I.M., Dewire J., Mager M., Maqbool F., Zimmerman S.L., Zipunnikov V., Beinart R., Marine J.E., Spragg D.D., Berger R.D., Ashikaga H., Nazarian S., Calkins H. Relationship between left atrial appendage morphology and stroke in patients with atrial fibrillation. Heart Rhythm. 2013;10(12):1843-9.doi:10.1016/j.hrthm.2013.09.065Masci A., Barone L., Dedè L., Fedele M., Tomasi C., Quarteroni A., Corsi C. The Impact of Left Atrium Appendage Morphology on Stroke Risk Assessment in Atrial Fibrillation: A Computational Fluid Dynamics Study. Front Physiol. 2019;9:1938. doi:10.3389/fphys.2018.01938Masci A., Barone L., Dedè L., Fedele M., Tomasi C., Quarteroni A., Corsi C. The Impact of Left Atrium Appendage Morphology on Stroke Risk Assessment in Atrial Fibrillation: A Computational Fluid Dynamics Study. Front Physiol. 2019;9:1938. doi:10.3389/fphys.2018.01938Kim I.C., Hong G.R. Intraventricular Flow: More than Pretty Pictures. Heart Fail Clin. 2019;15(2):257-265. doi:10.1016/j.hfc.2018.12.005Kim I.C., Hong G.R. Intraventricular Flow: More than Pretty Pictures. Heart Fail Clin. 2019;15(2):257-265. doi:10.1016/j.hfc.2018.12.005

The authors declare that there are no conflicts of interest present.