Основные положения

kpccz

Комплексные проблемы сердечно-сосудистых заболеваний

Complex Issues of Cardiovascular Diseases

2306-12782587-9537

Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”

10.17802/2306-1278-2024-13-3-105-110

kpccz-1158

Research Article

АНАЛИТИЧЕСКИЙ ОБЗОР. Патологическая физиология

REVIEWS. Pathological physiology

РОЛЬ КЛЕТОЧНОЙ ПЛАСТИЧНОСТИ КЛЕТОК СОСУДИСТОЙ СТЕНКИ И КРОВЕТВОРНОЙ СИСТЕМЫ В АТЕРОГЕНЕЗЕ

THE ROLE OF CELLULAR PLASTICITY OF VASCULAR WALL CELLS AND HEMATOPOIETIC SYSTEM IN ATHEROGENESIS

https://orcid.org/0000-0003-3226-1750

Слепцов

Алексей Анатольевич

Sleptsov

Alexey A.

кандидат медицинских наук научный сотрудник лаборатории популяционной генетики федерального государственного бюджетного научного учреждения «Томский национальный исследовательский медицинский центр Российской академии наук» Научно-исследовательский институт медицинской генетики, Томск, Российская Федерация

PhD, Researcher at the Laboratory of Population Genetics, Federal State Budgetary Institution “Tomsk National Research Medical Center of the Russian Academy of Sciences”, Research Institute of Medical Genetics, Tomsk, Russian Federation

alexei.sleptcov@medgenetics.ru

Научно-исследовательский институт медицинской генетики федерального государственного бюджетного научного учреждения «Томский национальный исследовательский медицинский центр Российской академии наук»РоссияResearch Institute of Medical Genetics, Federal State Budgetary Institution “Tomsk National Research Medical Center of the Russian Academy of Sciences”Russian Federation

2024

30092024

133105110

2024

Слепцов А.А.

Sleptsov A.A.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nii-kpssz.com/jour/article/view/1158

Основные положения

Резюме

Прогресс, достигнутый за последнее десятилетие в области кардиогенетики, ознаменован главным образом работами, основанными на оценке наследуемых герминативных мутаций. Новые направления продемонстрировали значительную роль клеточной пластичности, соматического мозаицизма и клонального гемопоэза в структуре риска развития ишемической болезни сердца, а также острых сосудистых нарушений атерогенного происхождения. Секвенирование единичных клеток и масс-цитометрия позволили раскрыть принципиально новые механизмы развития атеросклероза. В обзоре освещены современные данные в области изучения атеросклероза и сосудистых нарушений с фокусом на клеточную пластичность, соматический мозаицизм и клональный гемопоэз.

Highlights

Abstract

The last decade of cardiogenetic studies focused on inherited germline mutations. Recently researchers demonstrated a significant role of cellular heterogeneity, somatic mosaicism, and clonal hematopoiesis in the risk of coronary disease and acute vascular disorders. Up-to-date technologies, such as single-cell sequencing and mass cytometry, have made it possible to reveal fundamentally new mechanisms for the development of cardiovascular diseases. This review discloses cutting-edge data on atherosclerosis and vascular disorders, focusing on cellular heterogeneity, somatic mosaicism, and clonal hematopoiesis.

АтеросклерозКлеточная пластичностьСоматическая мутацияКлональный гемопоэз с неопределенным потенциалом

AtherosclerosisCellular heterogeneitySomatic mutationClonal hematopoiesis with uncertain potential

Исследование поддержано грантом Российского научного фонда № 22-25-00745.

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The authors declare that there are no conflicts of interest present.