kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2023-12-1-118-128kpccz-1298Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОР. Сердечно-сосудистая хирургия. Патологическая физиологияREVIEW. Cardiovascular Surgery. Pathological PhysiologyТерапевтический ангиогенез как перспективное направление потенцирования ангиогенного действия аортокоронарного шунтированияTherapeutic angiogenesis as an advanced direction for potentiating the angiogenic effect of coronary artery bypass graftinghttps://orcid.org/0000-0002-4144-3946ОлейникБ. А.OleynikB. A.

Олейник Богдан Александрович, кандидат медицинских наук доцент кафедры госпитальной хирургии, 

ул. Ленина, 3, Уфа, 450008

Oleynik Bogdan A., PhD, Associate Professor of the Department of Advanced Surgery, 

3, Lenina St., Ufa, 450008

bogdan-ufa@mail.ruhttps://orcid.org/0000-0002-6716-4048ПлечевВ. В.PlechevV. V.

Плечев Владимир Вячеславович, доктор медицинских наук, профессор заведующий кафедрой госпитальной хирургии, 

ул. Ленина, 3, Уфа, 450008

Plechev Vladimir V., PhD, Professor, Head of the Department of Advanced Surgery,

3, Lenina St., Ufa, 450008

https://orcid.org/0000-0003-0000-1110СтародубовВ. И.StarodobovV. I.

Стародубов Владимир Иванович, академик РАН, доктор медицинских наук, профессор научный руководитель,

ул. Добролюбова, 11, Москва, 127254

Starodobov Vladimir I., Academician of the Russian Academy of Sciences, PhD, Professor, Director,

11, Dobrolyubova St., Moscow, 127254

https://orcid.org/0000-0002-5836-4427ЕвдаковВ. А.EvdakovV. A.

Евдаков Валерьян Алексеевич, доктор медицинских наук, профессор главный научный сотрудник отдела научных основ организации здравоохранения,

ул. Добролюбова, 11, Москва, 127254

Evdakov Valerian A., PhD, Professor Chief Researcher at the Department of Scientific Foundations of Healthcare Organization, 

11, Dobrolyubova St., Moscow, 127254

https://orcid.org/0000-0001-6216-2935ИжбульдинР. И.IzhbuldinR. I.

Ижбульдин Рамиль Ильдусович, доктор медицинских наук профессор кафедры госпитальной хирургии, 

ул. Ленина, 3, Уфа, 450008

Izhbuldin Ramil I., PhD, Professor of the Department of Advanced Surgery,

3, Lenina St., Ufa, 450008

Федеральное государственное бюджетное образовательное учреждение высшего образования Башкирский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Educational “Bashkir State Medical University” of the Ministry of Healthcare of the Russian FederationRussian FederationФедеральное государственное бюджетное учреждение «Центральный научно-исследовательский институт организации и информатизации здравоохранения» Министерства здравоохранения Российской ФедерацииРоссияFederal Research Institute for Health Organization and Informatics of the Ministry of Health of the Russian FederationRussian Federation202316032023121118128Copyright © Олейник Б.А., Плечев В.В., Стародубов В.И., Евдаков В.А., Ижбульдин Р.И., 20232023Олейник Б.А., Плечев В.В., Стародубов В.И., Евдаков В.А., Ижбульдин Р.И.Oleynik B.A., Plechev V.V., Starodobov V.I., Evdakov V.A., Izhbuldin R.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/1298Основные положения

Основные положения. В обзоре систематизированы результаты экспериментальных и клинических исследований по влиянию аортокоронарного шунтирования на процессы ангиогенеза и перспективы применения производных пиримидинов в терапевтическом ангиогенезе.

Резюме

Резюме. Аортокоронарное шунтирования выступает методом выбора при многососудистом поражении коронарного бассейна. Вместе с тем клиническая эффективность операции с течением времени снижается из-за прогрессирования атеросклероза в шунтах и нативных коронарных артериях. В этой связи представляют значительный научно-практический интерес раскрытие механизмов, влияющих на развитие микроциркуляторного русла при хирургической реваскуляризации миокарда, а также поиск фармакологических субстанций, способных стимулировать процесс ангиогенеза при проведении указанных операций с целью улучшения их непосредственных и отдаленных результатов. Статья представляет собой обзор экспериментальных и клинических исследований по влиянию аортокоронарного шунтирования на процессы ангиогенеза. Также в обзоре освещена роль производных пиримидинов в терапевтическом ангиогенезе при ишемической болезни сердца.

Highlights

Highlights. This review systematizes the results of experimental and clinical studies on the impact of coronary artery bypass grafting on angiogenesis and potential use of pyrimidine derivatives for therapeutic angiogenesis.

Abstract

Abstract. Coronary artery bypass grafting is the preferred treatment modality for multivessel coronary artery disease. However, the clinical efficacy of the procedure decreases over time due to the progression of atherosclerosis in the bypass grafts and native coronary arteries. In this regard, it is of great scientific and practical interest to disclose the mechanisms affecting the development of the microvasculature during myocardial surgical revascularization, as well as the search for pharmacological substances capable of stimulating the process of angiogenesis during these surgeries to improve short and long-term outcomes. The article presents a review of experimental and clinical studies on the effect of coronary artery bypass surgery on angiogenesis and highlights the place of pyrimidine derivatives in therapeutic angiogenesis in coronary artery disease.

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The authors declare that there are no conflicts of interest present.