kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2015-3-28-36kpccz-137Research ArticleФУНДАМЕНТАЛЬНЫЕ АСПЕКТЫ БОЛЕЗНЕЙ ОРГАНОВ КРОВООБРАЩЕНИЯFUNDAMENTAL ISSUES IN CIRCULATORY SYSTEM DISEASESАССОЦИАЦИИ ВАРИАБЕЛЬНЫХ ЛОКУСОВ ГЕНОВ TLRS С НАРУШЕНИЯМИ УГЛЕВОДНОГО ОБМЕНА У ПАЦИЕНТОВ С ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦАASSOCIATION OF THE POLYMORPHISMS WITHIN THE GENES ENCODING TOLL-LIKE RECEPTORS WITH CARBOHYDRATE METABOLISM DISORDERS IN PATIENTS WITH CORONARY ARTERY DISEASEБарбарашО. Л.BarbarashO. L.

650002, г. Кемерово, Сосновый бульвар, д. 6

6, Sosnoviy blvd., Kemerovo, 650002

ГоловкинА. С.GolovkinA. S.

Санкт-Петербург

Saint Petersburg

ПонасенкоА. В.PonasenkoA. V.

650002, г. Кемерово, Сосновый бульвар, д. 6

6, Sosnoviy blvd., Kemerovo, 650002

КутихинА. Г.KutikhinA. G.

650002, г. Кемерово, Сосновый бульвар, д. 6

6, Sosnoviy blvd., Kemerovo, 650002

ЖидковаИрина ИгоревнаZhidkovaIrina I.

650002, г. Кемерово, Сосновый бульвар, д. 6

6, Sosnoviy blvd., Kemerovo, 650002

Irina04046@yandex.ruХуторнаяМ. В.KhutornayaM. V.

650002, г. Кемерово, Сосновый бульвар, д. 6

6, Sosnoviy blvd., Kemerovo, 650002

БарбарашЛ. С.BarbarashL. S.

650002, г. Кемерово, Сосновый бульвар, д. 6

6, Sosnoviy blvd., Kemerovo, 650002

Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияFederal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular DiseasesRussian FederationФедеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр им. В. А. Алмазова»РоссияFederal state budgetary institution Federal North-West medical research centre named after V. A. Almazov of Ministry of healthcare of the Russian FederationRussian Federation201524112015032836Copyright © Барбараш О.Л., Головкин А.С., Понасенко А.В., Кутихин А.Г., Жидкова И.И., Хуторная М.В., Барбараш Л.С., 20152015Барбараш О.Л., Головкин А.С., Понасенко А.В., Кутихин А.Г., Жидкова И.И., Хуторная М.В., Барбараш Л.С.Barbarash O.L., Golovkin A.S., Ponasenko A.V., Kutikhin A.G., Zhidkova I.I., Khutornaya M.V., Barbarash L.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/137Цель

Цель. Выявить ассоциации полиморфных вариантов генов TLRs с нарушением углеводного обмена (НУО) у пациентов с ишемической болезнью сердца (ИБС).

Материалы и методы

Материалы и методы. В исследование включено 292 пациента с ИБС с наличием НУО и без такового. Изучены вероятность наличия ассоциаций восьми полиморфных вариантов четырех генов (TLR1 (rs5743551 и rs5743611), TLR2 (rs3804099 и rs5743708), TLR4 (rs4986790 и rs4986791), TLR6 (rs3775073 и rs5743810) и развитие НУО у пациентов с ИБС.

Результаты

Результаты. Аллель T полиморфизма rs4986791 (Thr399Ile) и аллель G полиморфизма rs4986790 (Asp299Gly) TLR4 стати- стически значимо ассоциированы со сниженной вероятностью развития нарушений углеводного обмена; носители вариантного G аллеля полиморфизма rs5743611 TLR1 имеют повышенный риск развития нарушений углеводного обмена.

Заключение

Заключение. Выявлены ассоциации полиморфных вариантов генов TLRs (аллель T полиморфизма rs4986791 и аллель G полиморфизма rs4986790 гена TLR4; G аллель полиморфизма rs5743611 гена TLR1) с НУО у пациентов с ИБС.

 

 

Purpose

Purpose. To reveal the association of polymorphisms within the genes encoding Toll-like receptors (TLRs) with carbohydrate metabolism disorders (CMDs) in patients with coronary artery disease (CAD).

Materials and methods

Materials and methods. Study sample included 292 patients with coronary artery disease. We investigated 8 polymorphisms within 4 genes: TLR1 (rs5743551 and rs5743611), TLR2 (rs3804099 and rs5743708), TLR4 (rs4986790 and rs4986791), TLR6 (rs3775073 and rs5743810).

Results

Results. T allele of the rs4986791 (Thr399Ile) polymorphism and G allele of rs4986790 (Asp299Gly) polymorphism within TLR4 gene are significantly associated with decreased risk of CMDs, whereas G allele of rs5743611 polymorphism within TLR1 gene is significantly associated with higher risk of CMDs.

Conclusion

Conclusion. We found significant associations of the polymorphisms within the genes encoding TLRs (T allele of rs4986791 polymorphism and G allele of rs4986790 polymorphism within TLR4 gene and G allele of rs5743611 polymorphism within TLR1 gene) with CMDs in patients with CAD.

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The authors declare that there are no conflicts of interest present.