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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kpccz</journal-id><journal-title-group><journal-title xml:lang="ru">Комплексные проблемы сердечно-сосудистых заболеваний</journal-title><trans-title-group xml:lang="en"><trans-title>Complex Issues of Cardiovascular Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2306-1278</issn><issn pub-type="epub">2587-9537</issn><publisher><publisher-name>Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17802/2306-1278-2023-12-4-228-234</article-id><article-id custom-type="elpub" pub-id-type="custom">kpccz-1408</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОНЛАЙН. АНАЛИТИЧЕСКИЙ ОБЗОР. Анестезиология и реаниматология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ONLINE. REVIEW. INTENSIVE CARE</subject></subj-group></article-categories><title-group><article-title>РОЛЬ ГИПОТЕРМИИ ДЛЯ ЦЕРЕБРОПРОТЕКЦИИ ПРИ ХИРУРГИЧЕСКОЙ КОРРЕКЦИИ ВРОЖДЕННЫХ ПОРОКОВ СЕРДЦА</article-title><trans-title-group xml:lang="en"><trans-title>ROLE OF HYPOTHERMIA IN CEREBRAL PROTECTION IN SURGICAL CORRECTION OF CONGENITAL HEART DEFECTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3899-1642</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивкин</surname><given-names>Артём Александрович</given-names></name><name name-style="western" xml:lang="en"><surname>Ivkin</surname><given-names>Artem A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук научный сотрудник лаборатории анестезиологии-реаниматологии и патофизиологии критических состояний отдела хирургии сердца и сосудов федерального государственного бюджетного научного учреждения «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Российская Федерация</p></bio><bio xml:lang="en"><p>Researcher at the Laboratory of Anesthesiology and Resuscitation, Intensive Care and Pathophysiology of Critical Illness, Department of Cardiovascular Surgery, Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo, Russian Federation</p></bio><email xlink:type="simple">aai-tema@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8370-3083</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорьев</surname><given-names>Евгений Валерьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Grigoriev</surname><given-names>Evgeny V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор РАН заместитель директора по научной и лечебной работе федерального государственного бюджетного научного учреждения «Научный исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Российская Федерация</p></bio><bio xml:lang="en"><p>PhD, Professor of the Russian Academy of Sciences, Deputy Director for Medicine and Scientific Work, Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo, Russian Federation</p></bio><email xlink:type="simple">grigorievev@hotmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Российская Федерация<country>Россия</country></aff><aff xml:lang="en">Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo, Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>25</day><month>12</month><year>2023</year></pub-date><volume>12</volume><issue>4</issue><fpage>228</fpage><lpage>234</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ивкин А.А., Григорьев Е.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Ивкин А.А., Григорьев Е.В.</copyright-holder><copyright-holder xml:lang="en">Ivkin A.A., Grigoriev E.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nii-kpssz.com/jour/article/view/1408">https://www.nii-kpssz.com/jour/article/view/1408</self-uri><abstract><sec><title>Основные положения</title><p>Основные положения</p><p>Представлен обзор исследований о механизмах церебропротекции и влиянии гипотермии на пациента.</p></sec><sec><title> </title><p> </p></sec><sec><title>Резюме</title><p>Резюме</p><p>Ежегодно в мире проводят большое количество хирургических коррекций врожденных пороков сердца, большую часть из них – с использованием искусственного кровообращения. Любая такая операция имеет набор патологических для головного мозга факторов, в некоторых хирургическая стратегия предполагает применение гипотермии. В частности, гипотермия должна обладать нейропротективным эффектом, однако, как показывают последние исследования, это не всегда так. Обзор посвящен механизмам влияния гипотермии на организм пациента, среди которых не только снижение метаболизма мозга, но и ряд других. Представлены актуальные работы о применении гипотермии при операциях, не требующих циркуляторного ареста, с анализом интра- и послеоперационного периода.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Highlights</title><p>Highlights</p><p>This article is devoted to a review of studies on the mechanisms of cerebral protection and the effects of hypothermia on the patient.</p></sec><sec><title> </title><p> </p></sec><sec><title>Abstract</title><p>Abstract</p><p>A large number of surgical corrections of congenital heart defects are performed around the world annually, most of them using cardiopulmonary bypass. This kind of surgery can be a pathological factor for the brain. In some patients, the kind of surgery involves the use of hypothermia. Supposedly, hypothermia should have a neuroprotective effect, however, as recent studies show, this is not always the case. This review is devoted to the mechanisms of the effect of hypothermia on the patient’s body, including not only a decrease in brain metabolism, but also a number of others. Moreover, a review of current works on the use of hypothermia in clinical practice in surgeries that do not require circulatory arrest is presented, along with an analysis of the intra- and postoperative period.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>Гипотермия</kwd><kwd>Церебропротекция</kwd><kwd>Искусственное кровообращение</kwd><kwd>Дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Hypothermia</kwd><kwd>Cerebral protection</kwd><kwd>Cardiopulmonary bypass</kwd><kwd>Children</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Исследование выполнено за счет гранта Российского научного фонда № 22-15-00258.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hottinger S. J., Liamlahi R., Feldmann M., Knirsch W., Latal B., Hagmann C.F.; Heart and Brain Research Group.. Postoperative improvement of brain maturation in infants with congenital heart disease. Semin Thorac Cardiovasc Surg. 2022; 34 (1): 251–259. doi: 10.1053/j. semtcvs.2020.11.029.</mixed-citation><mixed-citation xml:lang="en">Hottinger S. J., Liamlahi R., Feldmann M., Knirsch W., Latal B., Hagmann C.F.; Heart and Brain Research Group.. Postoperative improvement of brain maturation in infants with congenital heart disease. Semin Thorac Cardiovasc Surg. 2022; 34 (1): 251–259. doi: 10.1053/j. semtcvs.2020.11.029.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Борисенко Д.В., Ивкин А.А., Шукевич Д.Л. Современные методы ограничения системного воспалительного ответа при коррекции врожденных пороков сердца у детей в условиях искусственного кровообращения. Комплексные проблемы сердечно-сосудистых заболеваний. 2021;10 (2): 113-124. doi: 10.17802/2306-1278-2021-10-2-113-124</mixed-citation><mixed-citation xml:lang="en">Борисенко Д.В., Ивкин А.А., Шукевич Д.Л. Современные методы ограничения системного воспалительного ответа при коррекции врожденных пороков сердца у детей в условиях искусственного кровообращения. Комплексные проблемы сердечно-сосудистых заболеваний. 2021;10 (2): 113-124. doi: 10.17802/2306-1278-2021-10-2-113-124</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Karacaer F., Biricik E., Ilgınel M., Tunay D.L., Döğüş Y., Öztürk Ö.G., Güzel Y., Benli O., Güneş Y. The Anti-Inflammatory and Antioxidant Effects of Propofol and Sevoflurane in Children With Cyanotic Congenital Heart Disease. J Cardiothorac Vasc Anesth. 2023; 37(1): 65-72. doi: 10.1053/j.jvca.2022.09.094.</mixed-citation><mixed-citation xml:lang="en">Karacaer F., Biricik E., Ilgınel M., Tunay D.L., Döğüş Y., Öztürk Ö.G., Güzel Y., Benli O., Güneş Y. The Anti-Inflammatory and Antioxidant Effects of Propofol and Sevoflurane in Children With Cyanotic Congenital Heart Disease. J Cardiothorac Vasc Anesth. 2023; 37(1): 65-72. doi: 10.1053/j.jvca.2022.09.094.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Wiberg S., Holmgaard F., Zetterberg H., Nilsson J.C., Kjaergaard J., Wanscher M., Langkilde A.R., Hassager C., Rasmussen L.S., Blennow K., Vedel A.G. Biomarkers of Cerebral Injury for Prediction of Postoperative Cognitive Dysfunction in Patients Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022; 36(1): 125-132. doi: 10.1053/j.jvca.2021.05.016</mixed-citation><mixed-citation xml:lang="en">Wiberg S., Holmgaard F., Zetterberg H., Nilsson J.C., Kjaergaard J., Wanscher M., Langkilde A.R., Hassager C., Rasmussen L.S., Blennow K., Vedel A.G. Biomarkers of Cerebral Injury for Prediction of Postoperative Cognitive Dysfunction in Patients Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022; 36(1): 125-132. doi: 10.1053/j.jvca.2021.05.016</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sun L., Zhang K., Chen H., Ji W., Huang Y., Zhang M., Zheng J. Age-related changes in cerebral hemodynamics in children undergoing congenital cardiac surgery: a prospective observational study. J Cardiothorac Vasc Anesth. 2022; 36 (6): 1617–1624. doi: 10.1053/j.jvca.2021.08.099.</mixed-citation><mixed-citation xml:lang="en">Sun L., Zhang K., Chen H., Ji W., Huang Y., Zhang M., Zheng J. Age-related changes in cerebral hemodynamics in children undergoing congenital cardiac surgery: a prospective observational study. J Cardiothorac Vasc Anesth. 2022; 36 (6): 1617–1624. doi: 10.1053/j.jvca.2021.08.099.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hansen T.G. Anesthesia-related neurotoxicity and the developing animal brain is not a significant problem in children. Paediatr Anaesth. 2015;25(1):65-72 doi:10.1111/pan.12548</mixed-citation><mixed-citation xml:lang="en">Hansen T.G. Anesthesia-related neurotoxicity and the developing animal brain is not a significant problem in children. Paediatr Anaesth. 2015;25(1):65-72 doi:10.1111/pan.12548</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Meyburg J., Dill M.L., Traube C., Silver G., von Haken R. Patterns of Post- operative Delirium in Children. Pediatric Critical Care Medicine. 2017; 18(2):128-133. doi: 10.1097/PCC.0000000000000993</mixed-citation><mixed-citation xml:lang="en">Meyburg J., Dill M.L., Traube C., Silver G., von Haken R. Patterns of Post- operative Delirium in Children. Pediatric Critical Care Medicine. 2017; 18(2):128-133. doi: 10.1097/PCC.0000000000000993</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ивкин А. А., Григорьев Е. В., Цепокина А. В., Шукевич Д.Л. Послеоперационный делирий у детей при коррекции врожденных септальных пороков сердца. Вестник анестезиологии и реаниматологии. 2021; 18 (2): 62–68. doi: 10.21292/2078-5658-2021-18-2-62-6.</mixed-citation><mixed-citation xml:lang="en">Ивкин А. А., Григорьев Е. В., Цепокина А. В., Шукевич Д.Л. Послеоперационный делирий у детей при коррекции врожденных септальных пороков сердца. Вестник анестезиологии и реаниматологии. 2021; 18 (2): 62–68. doi: 10.21292/2078-5658-2021-18-2-62-6.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bigelow W.G., Lindsay W.K., Greenwood W.F. Hypothermia: Its Possible Role in Cardiac Surgery: An Investigation of Factors Governing Survival in Dogs at Low Body Temperatures. Ann Surg. 1950; 132: 849–866. doi: 10.1097/00000658-195011000-00001.</mixed-citation><mixed-citation xml:lang="en">Bigelow W.G., Lindsay W.K., Greenwood W.F. Hypothermia: Its Possible Role in Cardiac Surgery: An Investigation of Factors Governing Survival in Dogs at Low Body Temperatures. Ann Surg. 1950; 132: 849–866. doi: 10.1097/00000658-195011000-00001.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lewis F.J., Taufic M. Closure of Atrial Septal Defects with the Aid of Hypothermia; Experimental Accomplishments and the Report of One Successful Case. Surgery. 1953; 33: 52–59.</mixed-citation><mixed-citation xml:lang="en">Lewis F.J., Taufic M. Closure of Atrial Septal Defects with the Aid of Hypothermia; Experimental Accomplishments and the Report of One Successful Case. Surgery. 1953; 33: 52–59.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Weiss M., Piwnica A., Lenfant C., Sprovieri L., Laurent D., Blondeau P., Dubost C. Deep Hypothermia with Total Circulatory Arrest. Trans Am Soc Artif Intern Organs. 1960; 6: 227–239.</mixed-citation><mixed-citation xml:lang="en">Weiss M., Piwnica A., Lenfant C., Sprovieri L., Laurent D., Blondeau P., Dubost C. Deep Hypothermia with Total Circulatory Arrest. Trans Am Soc Artif Intern Organs. 1960; 6: 227–239.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Croughwell N., Smith L.R., Quill T., Newman M., Greeley W., Kern F., Joe Lu., Reves J.G. The effect of temperature on cerebral metabolism and blood flow in adults during cardiopulmonary bypass. J Thorac Cardiovasc Surg.1992; 103(3): 549–554. doi:10.1016/s0022-5223(19)34997-9</mixed-citation><mixed-citation xml:lang="en">Croughwell N., Smith L.R., Quill T., Newman M., Greeley W., Kern F., Joe Lu., Reves J.G. The effect of temperature on cerebral metabolism and blood flow in adults during cardiopulmonary bypass. J Thorac Cardiovasc Surg.1992; 103(3): 549–554. doi:10.1016/s0022-5223(19)34997-9</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Baumann E., Preston E., Slinn J., Stanimirovic D. Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia. Brain Research. 2009; 1269: 185–197. doi: 10.1016/j.brainres.2009.02.062.</mixed-citation><mixed-citation xml:lang="en">Baumann E., Preston E., Slinn J., Stanimirovic D. Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia. Brain Research. 2009; 1269: 185–197. doi: 10.1016/j.brainres.2009.02.062.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Matsui T., Kakeda T. IL-10 production is reduced by hypothermia but augmented by hyperthermia in rat microglia. Journal of Neurotrauma. 2008; 25(6): 709–715. doi: 10.1089/neu.2007.0482.</mixed-citation><mixed-citation xml:lang="en">Matsui T., Kakeda T. IL-10 production is reduced by hypothermia but augmented by hyperthermia in rat microglia. Journal of Neurotrauma. 2008; 25(6): 709–715. doi: 10.1089/neu.2007.0482.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kaushal V., Schlichter L.C. Mechanisms of microglia-mediated neurotox- icity in a new model of the stroke penumbra. J Neurosci. 2008; 28 (9): 2221-2230. doi: 10.1523/JNEUROSCI.5643-07.2008.</mixed-citation><mixed-citation xml:lang="en">Kaushal V., Schlichter L.C. Mechanisms of microglia-mediated neurotox- icity in a new model of the stroke penumbra. J Neurosci. 2008; 28 (9): 2221-2230. doi: 10.1523/JNEUROSCI.5643-07.2008.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Pozhilenkova E.A., Lopatina O.L., Komleva Y.K., Salmin V.V., Salmina A.B. Blood-brain barrier-supported neurogenesis in healthy and diseased brain. Rev Neurosci. 2017; 28 (4): 397-415. doi: 10.1515/revneuro-2016-0071.</mixed-citation><mixed-citation xml:lang="en">Pozhilenkova E.A., Lopatina O.L., Komleva Y.K., Salmin V.V., Salmina A.B. Blood-brain barrier-supported neurogenesis in healthy and diseased brain. Rev Neurosci. 2017; 28 (4): 397-415. doi: 10.1515/revneuro-2016-0071.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Murry C.E., Jennings R.B., Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986; 74 (5): 1124-36. doi: 10.1161/01.cir.74.5.1124.</mixed-citation><mixed-citation xml:lang="en">Murry C.E., Jennings R.B., Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986; 74 (5): 1124-36. doi: 10.1161/01.cir.74.5.1124.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fisher F.M., Kleiner S., Douris N., Fox E.C., Mepani R.J., Verdeguer F., Wu J., Kharitonenkov A., Flier J.S., Maratos-Flier E., Spiegelman B.M. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012; 26 (3): 271-281. doi: 10.1101/gad.177857.111.</mixed-citation><mixed-citation xml:lang="en">Fisher F.M., Kleiner S., Douris N., Fox E.C., Mepani R.J., Verdeguer F., Wu J., Kharitonenkov A., Flier J.S., Maratos-Flier E., Spiegelman B.M. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012; 26 (3): 271-281. doi: 10.1101/gad.177857.111.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Herrmann J.R., Fink E.L., Fabio A., Berger R.P., Janesko-Feldman K., Gorse K., Clark R.S.B., Kochanek P.M., Jackson T.C. Characterization of Circulating Cold Shock Proteins FGF21 and RBM3 in a Multi-Center Study of Pediatric Cardiac Arrest. Ther Hypothermia Temp Manag. 2023 Sep 5. doi: 10.1089/ther.2023.0035.</mixed-citation><mixed-citation xml:lang="en">Herrmann J.R., Fink E.L., Fabio A., Berger R.P., Janesko-Feldman K., Gorse K., Clark R.S.B., Kochanek P.M., Jackson T.C. Characterization of Circulating Cold Shock Proteins FGF21 and RBM3 in a Multi-Center Study of Pediatric Cardiac Arrest. Ther Hypothermia Temp Manag. 2023 Sep 5. doi: 10.1089/ther.2023.0035.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Herrmann J.R., Fink E.L., Fabio A., Au A.K., Berger R.P., Janesko-Feldman K., Clark R.S.B., Kochanek P.M., Jackson T.C. Serum levels of the cold stress hormones FGF21 and GDF-15 after cardiac arrest in infants and children enrolled in single center therapeutic hypothermia clinical trials. Resuscitation. 2022; 172: 173-180. doi: 10.1016/j.resuscitation.2021.11.016.</mixed-citation><mixed-citation xml:lang="en">Herrmann J.R., Fink E.L., Fabio A., Au A.K., Berger R.P., Janesko-Feldman K., Clark R.S.B., Kochanek P.M., Jackson T.C. Serum levels of the cold stress hormones FGF21 and GDF-15 after cardiac arrest in infants and children enrolled in single center therapeutic hypothermia clinical trials. Resuscitation. 2022; 172: 173-180. doi: 10.1016/j.resuscitation.2021.11.016.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hu Y., Liu Y., Quan X., Fan W., Xu B., Li S. RBM3 is an outstanding cold shock protein with multiple physiological functions beyond hypothermia. J Cell Physiol. 2022; 237 (10): 3788-3802. doi: 10.1002/jcp.30852</mixed-citation><mixed-citation xml:lang="en">Hu Y., Liu Y., Quan X., Fan W., Xu B., Li S. RBM3 is an outstanding cold shock protein with multiple physiological functions beyond hypothermia. J Cell Physiol. 2022; 237 (10): 3788-3802. doi: 10.1002/jcp.30852</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Corre M., Lebreton A. Regulation of cold-inducible RNA-binding protein (CIRBP) in response to cellular stresses. Biochimie. 2023;8:S0300-9084(23):80-89. doi: 10.1016/j.biochi.2023.04.003</mixed-citation><mixed-citation xml:lang="en">Corre M., Lebreton A. Regulation of cold-inducible RNA-binding protein (CIRBP) in response to cellular stresses. Biochimie. 2023;8:S0300-9084(23):80-89. doi: 10.1016/j.biochi.2023.04.003</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sun W., Liao Y., Yi Q., Wu S., Tang L., Tong L. The Mechanism of CIRP in Regulation of STAT3 Phosphorylation and Bag-1/S Expression Upon UVB Radiation. Photochem Photobiol. 2018; 94 (6): 1234-1239. doi: 10.1111/php.1298</mixed-citation><mixed-citation xml:lang="en">Sun W., Liao Y., Yi Q., Wu S., Tang L., Tong L. The Mechanism of CIRP in Regulation of STAT3 Phosphorylation and Bag-1/S Expression Upon UVB Radiation. Photochem Photobiol. 2018; 94 (6): 1234-1239. doi: 10.1111/php.1298</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Liu M., Li Y., Gao S., Yan S., Zhang Q., Liu G., Ji B. A novel target to reduce microglial inflammation and neuronal damage after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg. 2020; 159 (6): 2431-2444.. doi: 10.1016/j.jtcvs.2019.06.115</mixed-citation><mixed-citation xml:lang="en">Liu M., Li Y., Gao S., Yan S., Zhang Q., Liu G., Ji B. A novel target to reduce microglial inflammation and neuronal damage after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg. 2020; 159 (6): 2431-2444.. doi: 10.1016/j.jtcvs.2019.06.115</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Jackson T.C., Kotermanski S.E., Kochanek P.M. Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain. Journal of Developmental Neuroscience. 2018; 40 (4): 325-336. doi: 10.1159/000493637</mixed-citation><mixed-citation xml:lang="en">Jackson T.C., Kotermanski S.E., Kochanek P.M. Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain. Journal of Developmental Neuroscience. 2018; 40 (4): 325-336. doi: 10.1159/000493637</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Jain V.. Langham M.C.. Wehrli F.W. MRI Estimation of Global Brain Oxygen Consumption Rate. J Cereb Blood Flow Metab.2010; 30: 1598–1607. doi: 10.1038/jcbfm.2010.49</mixed-citation><mixed-citation xml:lang="en">Jain V.. Langham M.C.. Wehrli F.W. MRI Estimation of Global Brain Oxygen Consumption Rate. J Cereb Blood Flow Metab.2010; 30: 1598–1607. doi: 10.1038/jcbfm.2010.49</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Norwood W.I., Norwood C.R. Influence of Hypothermia on Intracellular PH during Anoxia. Am. J. Physiol. 1982; 243: 62–65</mixed-citation><mixed-citation xml:lang="en">Norwood W.I., Norwood C.R. Influence of Hypothermia on Intracellular PH during Anoxia. Am. J. Physiol. 1982; 243: 62–65</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Jonas R.A., Bellinger D.C., Rappaport L.A., Wernovsky G., Hickey P.R., Farrell D.M., Newburger J.W. Relation of PH Strategy and Developmental Outcome after Hypothermic Circulatory Arrest. J Thorac Cardiovasc Surg. 1993; 106: 362–368</mixed-citation><mixed-citation xml:lang="en">Jonas R.A., Bellinger D.C., Rappaport L.A., Wernovsky G., Hickey P.R., Farrell D.M., Newburger J.W. Relation of PH Strategy and Developmental Outcome after Hypothermic Circulatory Arrest. J Thorac Cardiovasc Surg. 1993; 106: 362–368</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Maisat W., Yuki K. Narrative review of systemic inflammatory response mechanisms in cardiac surgery and immunomodulatory role of anesthetic agents. Narrative review of systemic inflammatory response mechanisms in cardiac surgery and immunomodulatory role of anesthetic agents. Annals of Cardiac 2023; 26 (2): 133-142. doi: 10.4103/aca.aca_147_22.</mixed-citation><mixed-citation xml:lang="en">Maisat W., Yuki K. Narrative review of systemic inflammatory response mechanisms in cardiac surgery and immunomodulatory role of anesthetic agents. Narrative review of systemic inflammatory response mechanisms in cardiac surgery and immunomodulatory role of anesthetic agents. Annals of Cardiac 2023; 26 (2): 133-142. doi: 10.4103/aca.aca_147_22.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Deist F. L., Menasché P., Kucharski C. Hypothermia during cardiopulmo- nary bypass delays but does not prevent neutrophil-endothelial cell adhesion. A clinical study. Circulation. 1995; 92 (9): 354–358.</mixed-citation><mixed-citation xml:lang="en">Deist F. L., Menasché P., Kucharski C. Hypothermia during cardiopulmo- nary bypass delays but does not prevent neutrophil-endothelial cell adhesion. A clinical study. Circulation. 1995; 92 (9): 354–358.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Stocker C. F., Shekerdemian L. S., Horton S. B. The influence of bypass temperature on the systemic inflammatory response and organ injury after pediatric open surgery: a randomized trial. J Thorac Cardiovasc Surg. 2011. 142 (1): 174–180. doi: 10.1016/j.jtcvs.2011.01.059</mixed-citation><mixed-citation xml:lang="en">Stocker C. F., Shekerdemian L. S., Horton S. B. The influence of bypass temperature on the systemic inflammatory response and organ injury after pediatric open surgery: a randomized trial. J Thorac Cardiovasc Surg. 2011. 142 (1): 174–180. doi: 10.1016/j.jtcvs.2011.01.059</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Caputo M., Pike K., Baos S., Sheehan K., Selway K., Ellis L., Stoica S., Parry A., Clayton G., Culliford L., Angelini G.D., Pandey R., Rogers C.A. Normothermic versus hypothermic cardiopulmonary bypass in low-risk paediatric heart surgery: a randomised controlled trial. Heart. 2019; 105 (6): 455-464. doi: 10.1136/heartjnl-2018-313567</mixed-citation><mixed-citation xml:lang="en">Caputo M., Pike K., Baos S., Sheehan K., Selway K., Ellis L., Stoica S., Parry A., Clayton G., Culliford L., Angelini G.D., Pandey R., Rogers C.A. Normothermic versus hypothermic cardiopulmonary bypass in low-risk paediatric heart surgery: a randomised controlled trial. Heart. 2019; 105 (6): 455-464. doi: 10.1136/heartjnl-2018-313567</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Corno A.F., Bostock C., Chiles S.D., Wright J., Tala M.J., Mimic B., Cvetkovic M. Comparison of Early Outcomes for Normothermic and Hypothermic Cardiopulmonary Bypass in Children Undergoing Congenital Heart Surgery. Frontiers in Pediatrics. 2018; 17 (6): 219-225. doi: 10.3389/fped.2018.00219</mixed-citation><mixed-citation xml:lang="en">Corno A.F., Bostock C., Chiles S.D., Wright J., Tala M.J., Mimic B., Cvetkovic M. Comparison of Early Outcomes for Normothermic and Hypothermic Cardiopulmonary Bypass in Children Undergoing Congenital Heart Surgery. Frontiers in Pediatrics. 2018; 17 (6): 219-225. doi: 10.3389/fped.2018.00219</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Felfernig M., Blaicher S., Kettner C. Effects of temperature on partial thromboplastin time in heparinized plasma in vitro. Eur J Anaesthesiol. 2001; 18 (7): 467–470. doi: 10.1046/j.1365-2346.2001.00869.x</mixed-citation><mixed-citation xml:lang="en">Felfernig M., Blaicher S., Kettner C. Effects of temperature on partial thromboplastin time in heparinized plasma in vitro. Eur J Anaesthesiol. 2001; 18 (7): 467–470. doi: 10.1046/j.1365-2346.2001.00869.x</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Di Gregorio G., Sella N., Spiezia L., Menin E., Boscolo A., Pasin L., Pittarello D., Vida V., Simioni P., Navalesi P. Cardiopulmonary bypass-induced coagulopathy in pediatric patients: The role of platelets in postoperative bleeding. A preliminary study. Artif Organs. 2021; 45 (8): 852–860. doi: 10.1111/aor.13912</mixed-citation><mixed-citation xml:lang="en">Di Gregorio G., Sella N., Spiezia L., Menin E., Boscolo A., Pasin L., Pittarello D., Vida V., Simioni P., Navalesi P. Cardiopulmonary bypass-induced coagulopathy in pediatric patients: The role of platelets in postoperative bleeding. A preliminary study. Artif Organs. 2021; 45 (8): 852–860. doi: 10.1111/aor.13912</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Alkhatip A.M., Kamel M.G., Farag E.M., Elayashy M., Farag A., Yassin H.M., Bahr M.H., Abdelhaq M., Sallam A., Kamal A.M., Emady M.F.E., Wagih M., Naguib A.A., Helmy M., Algameel H.Z., Abdelkader M., Mohamed H., Younis M., Purcell A., Elramely M., Hamza M.K. Deep hypothermic circulatory arrest in the pediatric population undergoing cardiac surgery with electroencephalography monitoring: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth. 2021; 35 (10): 2875–2888. doi: 10.1053/j.jvca.2021.01.039</mixed-citation><mixed-citation xml:lang="en">Alkhatip A.M., Kamel M.G., Farag E.M., Elayashy M., Farag A., Yassin H.M., Bahr M.H., Abdelhaq M., Sallam A., Kamal A.M., Emady M.F.E., Wagih M., Naguib A.A., Helmy M., Algameel H.Z., Abdelkader M., Mohamed H., Younis M., Purcell A., Elramely M., Hamza M.K. Deep hypothermic circulatory arrest in the pediatric population undergoing cardiac surgery with electroencephalography monitoring: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth. 2021; 35 (10): 2875–2888. doi: 10.1053/j.jvca.2021.01.039</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Jungwirth B., Mackensen G.B., Blobner M., Neff F., Reichart B., Kochs E.F., Nollert G. Neurologic outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats: description of a new model. J Thorac Cardiovasc Surg. 2006; 131 (4): 805-812. doi: 10.1016/j.jtcvs.2005.11.017</mixed-citation><mixed-citation xml:lang="en">Jungwirth B., Mackensen G.B., Blobner M., Neff F., Reichart B., Kochs E.F., Nollert G. Neurologic outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats: description of a new model. J Thorac Cardiovasc Surg. 2006; 131 (4): 805-812. doi: 10.1016/j.jtcvs.2005.11.017</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Tu LN, Timms AE, Kibiryeva N, Bittel D, Pastuszko A, Nigam V, Pastuszko P. Transcriptome profiling reveals activation of inflammation and apoptosis in the neonatal striatum after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg.2019; 158 (3):882-890. doi: 10.1016/j.jtcvs.2019.02.091.</mixed-citation><mixed-citation xml:lang="en">Tu LN, Timms AE, Kibiryeva N, Bittel D, Pastuszko A, Nigam V, Pastuszko P. Transcriptome profiling reveals activation of inflammation and apoptosis in the neonatal striatum after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg.2019; 158 (3):882-890. doi: 10.1016/j.jtcvs.2019.02.091.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
