kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2025-14-1-232-240kpccz-1428Research ArticleОНЛАЙН. АНАЛИТИЧЕСКИЙ ОБЗОР. Кардиология. Внутренние болезниКОМПЛЕКСНАЯ ОЦЕНКА РОЛИ ПИТАНИЯ И МИКРОФЛОРЫ КИШЕЧНИКА В РАЗВИТИИ АТЕРОСКЛЕРОТИЧЕСКИХ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ (ОБЗОР ЛИТЕРАТУРЫ)COMPREHENSIVE ASSESSMENT OF THE ROLE OF NUTRITION AND INTESTINAL MICROFLORA IN THE DEVELOPMENT OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASES (LITERATURE REVIEW)https://orcid.org/0000-0003-1595-7692КурочкинаОльга НиколаевнаKurochkinaOlga N.

доктор медицинских наук профессор кафедры терапии медицинского института федерального государственного бюджетного учреждения высшего образования «Сыктывкарский государственный университет имени Питирима Сорокина» Министерства образования Российской Федерации, Сыктывкар, Российская Федерация

PhD, MD, Professor, Department of Therapy, Medical Institute, Federal State Budgetary Institution of Higher Education "Syktyvkar State University named after Pitirim Sorokin", Ministry of Education of the Russian Federation, Syktyvkar, Russian Federation

olga_kgma@mail.ruhttps://orcid.org/0009-0000-4268-3813КоротковДмитрий АлександровичKorotkovDmitry A.

кандидат медицинских наук главный врач государственного учреждения Республики Коми «Клинический кардиологический диспансер», Сыктывкар, Российская Федерация

PhD, Chief Physician of the State Institution of the Komi Republic "Clinical Cardiology Dispensary", Syktyvkar, Russian Federation

dmkorotkov@yandex.ruhttps://orcid.org/0000-0003-0019-0820БогомоловАндрей НиколаевичBogomolovAndrey N.

кандидат медицинских наук ведущий научный сотрудник лаборатории возрастной патологии сердечно-сосудистой системы Санкт-Петербургского государственного бюджетного учреждения здравоохранения «Городская Александровская больница», Санкт-Петербург, Российская Федерация

PhD, Leading Researcher at the Laboratory of Age-Related Pathology of the Cardiovascular System of the St. Petersburg State Budgetary Healthcare Institution Alexander City Hospital, St. Petersburg, Russian Federation

endovsurg@gmail.comФедеральное государственное бюджетное учреждение высшего образования «Сыктывкарский государственный университет имени Питирима Сорокина» Министерства образования Российской ФедерацииРоссияFederal State Budgetary Institution of Higher Education “Syktyvkar State University named after Pitirim Sorokin” of the Ministry of Education of the Russian FederationRussian FederationГосударственное учреждение Республики Коми «Клинический кардиологический диспансер»РоссияState Institution of Komi Republic “Clinical Cardiology Dispensary”Russian FederationСанкт-Петербургское государственное бюджетное учреждение здравоохранения «Городская Александровская больница»РоссияSt. Petersburg State Budgetary Healthcare Institution “Alexander City Hospital”Russian Federation202528022025141232240Copyright © Курочкина О.Н., Коротков Д.А., Богомолов А.Н., 20252025Курочкина О.Н., Коротков Д.А., Богомолов А.Н.Kurochkina O.N., Korotkov D.A., Bogomolov A.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/1428 

 

Основные положения

Основные положения

Потребление высококалорийной пищи западного типа в сочетании с перееданием и малоподвижным образом жизни обусловливает нарушение состава микробиоты кишечника, повышение проницаемости кишечника, увеличение поступления в кровь липополисахарида, триметиламин-N-оксида и других токсинов, что вызывает состояние хронического метаболического воспаления с последующим ускоренным развитием атеросклеротических сердечно-сосудистых заболеваний. Напротив, приверженность средиземноморской диете нормализует состав кишечной микробиоты, способствует повышению образования короткоцепочечных жирных кислот, обладающих противовоспалительным и антиатеросклеротическим действием.

 

 

Резюме

Резюме

Несмотря на внедрение новых методов лечения, атеросклеротические сердечно-сосудистые заболевания (ССЗ) остаются ведущей причиной заболеваемости и смертности во всем мире. В последние годы установлено, что системное воспаление играет решающую роль в атеротромбозе, но факторы, вызывающие системное воспаление, полностью не выяснены. Потребление высококалорийной пищи западного типа в сочетании с хроническим перееданием и малоподвижным образом жизни вызывает состояние хронического метаболического воспаления, которое способствует развитию атеросклеротических ССЗ. Лучшее понимание того, как различные типы питания влияют на патогенез атеросклероза, имеет важное значение для разработки эффективных стратегий профилактики и лечения атеросклеротических ССЗ. В статье рассмотрены последние данные о патогенетических механизмах влияния характера питания на развитие или регресс атеросклеротических ССЗ.

Highlights

Highlights

Consumption of high-calorie Western-type foods in combination with overeating and a sedentary lifestyle causes a violation of the composition of the intestinal microbiota, increased intestinal permeability, increased intake of lipopolysaccharide, trimethylamine-N-oxide and other toxins into the blood, which causes a state of chronic metabolic inflammation followed by accelerated development of ASD. Adherence to the Mediterranean diet normalizes the composition of the intestinal microbiota, promotes the formation of short-chain fatty acids with anti-inflammatory and anti-atherosclerotic effects.

 

 

Absract

Absract

Despite the introduction of new treatment methods, atherosclerotic cardiovascular diseases (ASCVD) remain the leading cause of morbidity and mortality worldwide. In recent years, it has been established that systemic inflammation plays a crucial role in atherothrombosis, but the factors causing systemic inflammation have not been fully elucidated. The consumption of high-calorie Western-type foods combined with chronic overeating and a sedentary lifestyle in Western societies causes a state of chronic metabolic inflammation, which contributes to the development of ASCVD. A better understanding of how different types of nutrition affect the pathogenesis of atherosclerosis is essential for developing effective strategies for the prevention and treatment of ASCVD. This article reviews the latest data on the pathogenetic mechanisms of the influence of dietary patterns on the development or regression of ASCVD.

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The authors declare that there are no conflicts of interest present.