kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2025-14-2-127-135kpccz-1540Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОР. Кардиология. Аритмология.REVIEW. Cardiology. ArrhythmologyУДЛИНЕНИЕ ИНТЕРВАЛА QTC: РОЛЬ ПОЛИПРАГМАЗИИ, ЛЕКАРСТВЕННОЕ ВЗАИМОДЕЙСТВИЕ И РЕКОМЕНДАЦИИ ДЛЯ КЛИНИЧЕСКОЙ ПРАКТИКИQTC INTERVAL PROLONGATION: ROLE OF POLYPHARMACY, DRUG INTERACTION AND CONSIDERATIONS FOR CLINICAL PRACTICEhttps://orcid.org/0000-0002-7019-650XКузьминВладимир ПетровичKuzminVladimir P.

PhD, Associate Professor at the Department of hospital therapy with courses of hematology and transfusiology, Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University”,  the Ministry of Healthcare of the Russian Federation, Samara, Russian Federation

v.p.kuzmin@samsmu.ruhttps://orcid.org/0000-0002-0555-4016ЗолотовскаяИрина АлександровнаZolotovskayaIrina A.

PhD, Professor at the Department of Hospital Therapy with courses of hematology and transfusiology, Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University”, the Ministry of Healthcare of the Russian Federation, Samara, Russian Federation

i.a.zolotovskaya@samsmu.ruhttps://orcid.org/0000-0002-1100-3798КривоваСветлана ПетровнаKrivovaSvetlana P.

PhD, Associate Professor at the Department of Hospital Therapy with courses of hematology and transfusiology, Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University”, the Ministry of Healthcare of the Russian Federation, Samara, Russian Federation

s.p.krivova@samsmu.ruhttps://orcid.org/0000-0002-7983-642XХайретдиновРаис КатдусовичKhayretdinovRais K.

PhD, Associate Professor at the Department of Hospital Therapy with courses of hematology and transfusiology, Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University”, the Ministry of Healthcare of the Russian Federation, Samara, Russian Federation

r.k.hajretdinov@samsmu.ruhttps://orcid.org/0009-0008-7271-8077РодионоваВиолетта АнатольевнаRodionovaVioletta A.

PhD, Samara Regional Clinical Oncology Hospital, Samara, Russian Federation

Vita800@yandex.ruhttps://orcid.org/0000-0001-9351-6177РубаненкоОлеся АнатольевнаRubanenkoOlesya A.

PhD, Associate Professor of the Department of Hospital Therapy with courses of hematology and transfusiology, Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University”, the Ministry of Healthcare of the Russian Federation, Samara, Russian Federation

olesya.rubanenko@gmail.comhttps://orcid.org/0000-0002-4318-4247ДавыдкинИгорь ЛеонидовичDavydkinIgor L.

PhD, Professor, Head of the Department of Hospital Therapy with courses of hematology and transfusiology, Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University”, the Ministry of Healthcare of the Russian Federation, Samara, Russian Federation

dagi2006@rambler.ruФедеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения РФРоссияFederal State Budgetary Educational Institution of Higher Education “Samara State Medical University” of the Ministry of Healthcare of the Russian FederationRussian FederationFederal State Budgetary Educational Institution of Higher Education “Samara State Medical University” of the Ministry of Healthcare of the Russian FederationRussian FederationSamara Regional Clinical Oncology HospitalRussian Federation202505052025142127135Copyright © Кузьмин В.П., Золотовская И.А., Кривова С.П., Хайретдинов Р.К., Родионова В.А., Рубаненко О.А., Давыдкин И.Л., 20252025Кузьмин В.П., Золотовская И.А., Кривова С.П., Хайретдинов Р.К., Родионова В.А., Рубаненко О.А., Давыдкин И.Л.Kuzmin V.P., Zolotovskaya I.A., Krivova S.P., Khayretdinov R.K., Rodionova V.A., Rubanenko O.A., Davydkin I.L.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/1540Основные положения

Основные положения

Приобретенный синдром удлиненного интервала QT – редкое заболевание, но частота его встречаемости растет при полипрагмазии.

 

 

Резюме

Резюме

Приобретенный синдром удлиненного интервала QT является редким заболеванием. Однако частота встречаемости удлиненного интервала QTc увеличивается у пациентов с полипрагмазией. Риск как удлинения интервала QTc, так и тахикардии типа «пируэт» возрастает экспоненциально при одновременном применении нескольких препаратов, удлиняющих интервал QTc. В статье показаны механизмы, лежащие в основе заболевания, и способы снижения риска потенциально фатальных аритмий.

Highlights

Highlights

Acquired long QT syndrome is a rare disease, but the frequency of QTc prolongation increases with polypragmasia.

 

 

Abstract

Abstract

Acquired long QT syndrome is a rare condition. However, the prevalence of prolonged QTc interval increases among patients with polypharmacy. The risk of both QTc interval prolongation and torsades de pointes (TdP) tachycardia escalates exponentially with the concomitant use of multiple QTc-prolonging drugs. This article explores the underlying mechanisms of the condition and methods to mitigate the risk of potentially fatal arrhythmias.

Удлинение интервала QTЛекарственно индуцированное удлинение интервала QTПобочные эффекты лекарственных средствТахикардия типа «пируэт»Внезапная сердечная смертьQT interval prolongationDrug-induced QT prolongationDrug side effectsTorsades de pointesSudden cardiac deathThe authors declare no research funding.ReferencesCastiglione A., Odening K. QT-Zeit – Was fange ich eigentlich damit an? [QT Interval and Its Prolongation - What Does It Mean?]. Dtsch Med Wochenschr. 2020;145(8):536-542. doi: 10.1055/a-0969-6312.Castiglione A., Odening K. QT-Zeit – Was fange ich eigentlich damit an? [QT Interval and Its Prolongation - What Does It Mean?]. Dtsch Med Wochenschr. 2020;145(8):536-542. doi: 10.1055/a-0969-6312.Uvelin A., Pejaković J., Mijatović V. Acquired prolongation of QT interval as a risk factor for torsade de pointes ventricular tachycardia: a narrative review for the anesthesiologist and intensivist. 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The authors declare that there are no conflicts of interest present.