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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kpccz</journal-id><journal-title-group><journal-title xml:lang="ru">Комплексные проблемы сердечно-сосудистых заболеваний</journal-title><trans-title-group xml:lang="en"><trans-title>Complex Issues of Cardiovascular Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2306-1278</issn><issn pub-type="epub">2587-9537</issn><publisher><publisher-name>Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17802/2306-1278-2025-14-6S-31-39</article-id><article-id custom-type="elpub" pub-id-type="custom">kpccz-1695</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ. Кардиология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES. Cardiology</subject></subj-group></article-categories><title-group><article-title>ДИНАМИКА ПОКАЗАТЕЛЕЙ СТАРЧЕСКОЙ АСТЕНИИ У ПАЦИЕНТОВ ПОСЛЕ ПРОВЕДЕНИЯ ПРЯМОЙ РЕВАСКУЛЯРИЗАЦИИ МИОКАРДА</article-title><trans-title-group xml:lang="en"><trans-title>CHANGES IN INDICATORS OF FRAILTY IN PATIENTS AFTER DIRECT MYOCARDIAL REVASCULARIZATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2384-5682</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кривошапова</surname><given-names>Кристина Евгеньевна</given-names></name><name name-style="western" xml:lang="en"><surname>Krivoshapova</surname><given-names>Kristina E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук научный сотрудник лаборатории коморбидности при сердечно-сосудистых заболеваниях отдела клинической кардиологии федерального государственного бюджетного научного учреждения «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Российская Федерация</p></bio><bio xml:lang="en"><p>PhD, Researcher at the Laboratory of Comorbidities in Cardiovascular Diseases, Department of Clinical Cardiology, Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo, Russian Federation; </p></bio><email xlink:type="simple">ya.kristi89@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3023-6239</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баздырев</surname><given-names>Евгений Дмитриевич</given-names></name><name name-style="western" xml:lang="en"><surname>Bazdyrev</surname><given-names>Evgeny D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук заведующий лабораторией эпидемиологии сердечно-сосудистых заболеваний отдела оптимизации медицинской помощи при сердечно-сосудистых заболеваниях федерального государственного бюджетного научного учреждения «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Российская Федерация</p></bio><bio xml:lang="en"><p>PhD, Head of the Laboratory of Epidemiology of Cardiovascular Diseases, Department of Optimization of Medical Care for Cardiovascular Diseases, Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo, Russian Federation</p></bio><email xlink:type="simple">edb624@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4642-3610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барбараш</surname><given-names>Ольга Леонидовна</given-names></name><name name-style="western" xml:lang="en"><surname>Barbarash</surname><given-names>Olga L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>академик РАН, доктор медицинских наук, профессор директор федерального государственного бюджетного научного учреждения «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Российская Федерация</p></bio><bio xml:lang="en"><p>Academician of the Russian Academy of Sciences, PhD, MD, Professor, Director of the Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo, Russian Federation</p></bio><email xlink:type="simple">olb61@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»<country>Россия</country></aff><aff xml:lang="en">Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>18</day><month>03</month><year>2026</year></pub-date><volume>14</volume><issue>6S</issue><fpage>31</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кривошапова К.Е., Баздырев Е.Д., Барбараш О.Л., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кривошапова К.Е., Баздырев Е.Д., Барбараш О.Л.</copyright-holder><copyright-holder xml:lang="en">Krivoshapova K.E., Bazdyrev E.D., Barbarash O.L.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nii-kpssz.com/jour/article/view/1695">https://www.nii-kpssz.com/jour/article/view/1695</self-uri><abstract><sec><title>Основные положения</title><p>Основные положения</p></sec><sec><title> </title><p> </p></sec><sec><title>Цель</title><p>Цель. Изучить динамику показателей преастении и синдрома старческой астении через три года после проведения первичного планового коронарного шунтирования.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включено 387 пациентов с многососудистым поражением коронарного русла перед проведением прямой реваскуляризации миокарда. Для выявления преастении и синдрома старческой астении были использованы различные диагностические подходы, такие как многоступенчатый диагностический алгоритм из клинических рекомендаций по старческой астении Общероссийской общественной организации «Российская ассоциация геронтологов и гериатров» 2020 г., опросник «PRISMA-7», критерии фенотипа «хрупкости» L.P. Fried, модифицированный индекс «хрупкости» mFI-5. Статистическая обработка результатов исследования проводилась с помощью пакета программ IBM SPSS Statistics 26.0.0.</p></sec><sec><title>Результаты</title><p>Результаты. При анализе клинико-анамнестической характеристики изучаемой выборки был получен классический портрет пациентов с многососудистым поражением коронарного русла, превалировали мужчины (73,1%), медиана возраста составила 65 [59; 69] лет. Частота встречаемости преастении среди пациентов с ишемической болезнью сердца варьировала от 15,0 до 42,4%, синдрома старческой астении от 22,5 до 71,6%. В течение трех лет после проведения планового коронарного шунтирования проявления патологического старения организма по данным нескольких диагностических подходов могут нарастать в среднем на 5,0–10,0%, при этом значимые различия были получены только при применении европейского опросника «PRISMA-7» (р = 0,045).</p></sec><sec><title>Заключение</title><p>Заключение. Прогрессирование старческой астении у пациентов с ишемической болезнью сердца через три года после проведения прямой реваскуляризации миокарда по результатам проведенного исследования варьирует в среднем от 5,0 до 10,0%.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Highlights</title><p>Highlights</p></sec><sec><title> </title><p> </p></sec><sec><title>Aim</title><p>Aim. To study the changes in indicators of pre-frailty and frailty syndrome in patients within three years after primary elective coronary artery bypass grafting.</p></sec><sec><title>Methods</title><p>Methods. The study included 387 patients with multivessel coronary artery disease before undergoing direct myocardial revascularization. Various diagnostic approaches were used to identify pre-frailty and frailty syndrome, such as a multi-stage diagnostic algorithm from the frailty recommendations of the Russian Public Organization «Russian Association of Gerontologists and Geriatricians» (2020), the «PRISMA-7» questionnaire, the criteria for the Fried frailty phenotype, and the 5-factor modified frailty index (mFI-5). Statistical processing of the results was carried out using the IBM SPSS Statistics 26.0.0 software.</p></sec><sec><title>Results</title><p>Results. The results of the analysis of the clinical and anamnestic characteristics of the sample revealed a classic portrait of patients with multivessel coronary artery disease, the majority of patients were men (73.1%), the median age was 65 [59; 69] years. The incidence of pre-frailty among patients with coronary artery disease ranged from 15.0 to 42.4%, and the incidence of frailty syndrome ranged from 22.5 to 71.6%. Within three years after elective coronary bypass surgery, according to several diagnostic approaches, the manifestations of pathological aging of the body can increase by an average of 5.0–10.0%, whereas using European «PRISMA-7» questionnaire revealed significant differences (p = 0.045).</p></sec><sec><title>Conclusions</title><p>Conclusions. The progression of frailty in patients with coronary artery disease three years after direct myocardial revascularization varies on average from 5.0 to 10.0% according to the results of the study.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>Преастения</kwd><kwd>Синдром старческой астении</kwd><kwd>«Хрупкость»</kwd><kwd>Многососудистое поражение коронарного русла</kwd><kwd>Коронарное шунтирование</kwd><kwd>Динамика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Pre-frailty</kwd><kwd>Frailty syndrome</kwd><kwd>«Frail»</kwd><kwd>Multivessel coronary artery disease</kwd><kwd>Coronary artery Bypass grafting</kwd><kwd>Dynamics</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Исследование выполнено в рамках фундаментальной научной темы НИИ КПССЗ № 0419-2022-0002 «Разработка инновационных моделей управления риском развития болезней системы кровообращения с учетом коморбидности на основе изучения фундаментальных, клинических, эпидемиологических механизмов и организационных технологий медицинской помощи в условиях промышленного региона Сибири (научный руководитель – академик РАН О.Л. Барбараш)», № госрегистрации 122012000364-5 от 20.01.2022 г.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hoogendijk E.O., Afilalo J., Ensrud K.E., Kowal P., Onder G., Fried L.P. Frailty: implications for clinical practice and public health. Lancet. 2019; 394 (10206): 1365-75. doi:10.1016/S0140-6736(19)31786-6</mixed-citation><mixed-citation xml:lang="en">Hoogendijk E.O., Afilalo J., Ensrud K.E., Kowal P., Onder G., Fried L.P. Frailty: implications for clinical practice and public health. Lancet. 2019; 394 (10206): 1365-75. doi:10.1016/S0140-6736(19)31786-6</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Walston J., Bandeen-Roche K., Buta B., Bergman H., Gill T.M., Morley J.E., et al. Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary. J Am Geriatr Soc. 2019; 67 (8): 1559-64. doi:10.1111/jgs.15928</mixed-citation><mixed-citation xml:lang="en">Walston J., Bandeen-Roche K., Buta B., Bergman H., Gill T.M., Morley J.E., et al. Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary. J Am Geriatr Soc. 2019; 67 (8): 1559-64. doi:10.1111/jgs.15928</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Mitnitski A.B., Song X., Rockwood K. The estimation of relative fitness and frailty in community-dwelling older adults using self-report data. J Gerontol A Biol Sci Med Sci. 2004; 59 (6): M627-32. doi:10.1093/gerona/59.6.m627</mixed-citation><mixed-citation xml:lang="en">Mitnitski A.B., Song X., Rockwood K. The estimation of relative fitness and frailty in community-dwelling older adults using self-report data. J Gerontol A Biol Sci Med Sci. 2004; 59 (6): M627-32. doi:10.1093/gerona/59.6.m627</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ayers E., Barzilai N., Crandall J.P., Milman S., Verghese J. Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging. J Gerontol A Biol Sci Med Sci. 2017; 72 (12): 1649-55. doi:10.1093/gerona/glx053</mixed-citation><mixed-citation xml:lang="en">Ayers E., Barzilai N., Crandall J.P., Milman S., Verghese J. Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging. J Gerontol A Biol Sci Med Sci. 2017; 72 (12): 1649-55. doi:10.1093/gerona/glx053</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Welstead M., Jenkins N.D., Russ T.C., Luciano M., Muniz-Terrera G. A Systematic Review of Frailty Trajectories: Their Shape and Influencing Factors. Gerontologist. 2021; 61 (8): e463-e475. doi:10.1093/geront/gnaa061</mixed-citation><mixed-citation xml:lang="en">Welstead M., Jenkins N.D., Russ T.C., Luciano M., Muniz-Terrera G. A Systematic Review of Frailty Trajectories: Their Shape and Influencing Factors. Gerontologist. 2021; 61 (8): e463-e475. doi:10.1093/geront/gnaa061</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Stow D., Matthews F.E., Hanratty B. Frailty trajectories to identify end of life: a longitudinal population-based study. BMC Med. 2018; 16 (1): 171. doi:10.1186/s12916-018-1148-x</mixed-citation><mixed-citation xml:lang="en">Stow D., Matthews F.E., Hanratty B. Frailty trajectories to identify end of life: a longitudinal population-based study. BMC Med. 2018; 16 (1): 171. doi:10.1186/s12916-018-1148-x</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">O’Caoimh R., Galluzzo L., Rodríguez-Laso Á., Van der Heyden J., Ranhoff A.H., Carcaillon-Bentata L., et al. Transitions and trajectories in frailty states over time: a systematic review of the European Joint Action ADVANTAGE. Ann Ist Super Sanita. 2018; 54 (3): 246-52. doi:10.4415/ANN_18_03_12</mixed-citation><mixed-citation xml:lang="en">O’Caoimh R., Galluzzo L., Rodríguez-Laso Á., Van der Heyden J., Ranhoff A.H., Carcaillon-Bentata L., et al. Transitions and trajectories in frailty states over time: a systematic review of the European Joint Action ADVANTAGE. Ann Ist Super Sanita. 2018; 54 (3): 246-52. doi:10.4415/ANN_18_03_12</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Loecker C., Schmaderer M., Zimmerman L. Frailty in Young and Middle-Aged Adults: An Integrative Review. J Frailty Aging. 2021; 10 (4): 327-333. doi:10.14283/jfa.2021.14</mixed-citation><mixed-citation xml:lang="en">Loecker C., Schmaderer M., Zimmerman L. Frailty in Young and Middle-Aged Adults: An Integrative Review. J Frailty Aging. 2021; 10 (4): 327-333. doi:10.14283/jfa.2021.14</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Crea F. The Atlas of cardiovascular disease in Europe and a focus on frailty and cardiovascular risk. Eur Heart J. 2022; 43 (8): 703-705. doi:10.1093/eurheartj/ehac066</mixed-citation><mixed-citation xml:lang="en">Crea F. The Atlas of cardiovascular disease in Europe and a focus on frailty and cardiovascular risk. Eur Heart J. 2022; 43 (8): 703-705. doi:10.1093/eurheartj/ehac066</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Damluji A.A., Cohen M.G. The influence of frailty on cardiovascular disease: the time for a «Frailty Academic Research Consortium» is now! Circ Cardiovasc Interv. 2022; 15: e011669. doi:10.1161/circinterventions.121.011669</mixed-citation><mixed-citation xml:lang="en">Damluji A.A., Cohen M.G. The influence of frailty on cardiovascular disease: the time for a «Frailty Academic Research Consortium» is now! Circ Cardiovasc Interv. 2022; 15: e011669. doi:10.1161/circinterventions.121.011669</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Orkaby A.R. Moving beyond chronological age: frailty as an important risk factor for cardiovascular disease. Eur Heart J. 2021; 42 (37): 3866-3868. doi:10.1093/eurheartj/ehab481</mixed-citation><mixed-citation xml:lang="en">Orkaby A.R. Moving beyond chronological age: frailty as an important risk factor for cardiovascular disease. Eur Heart J. 2021; 42 (37): 3866-3868. doi:10.1093/eurheartj/ehab481</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ijaz N., Buta B., Xue Q.L., Mohess D.T., Bushan A., Tran H., et al. Interventions for frailty among older adults with cardiovascular disease: JACC state-of-the-art review. J Am Coll Cardiol. 2022; 79: 482-503. doi:10.1016/j.jacc.2021.11.029</mixed-citation><mixed-citation xml:lang="en">Ijaz N., Buta B., Xue Q.L., Mohess D.T., Bushan A., Tran H., et al. Interventions for frailty among older adults with cardiovascular disease: JACC state-of-the-art review. J Am Coll Cardiol. 2022; 79: 482-503. doi:10.1016/j.jacc.2021.11.029</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shrauner W., Lord E.M., Nguyen X.T., Song R.J., Galloway A., Gagnon D.R., et al. Frailty and cardiovascular mortality in more than 3 million US veterans. Eur Heart J. 2022; 43: 818-26. doi:10.1093/eurheartj/ehab850</mixed-citation><mixed-citation xml:lang="en">Shrauner W., Lord E.M., Nguyen X.T., Song R.J., Galloway A., Gagnon D.R., et al. Frailty and cardiovascular mortality in more than 3 million US veterans. Eur Heart J. 2022; 43: 818-26. doi:10.1093/eurheartj/ehab850</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chen L., Li X., Lv Y., Tan X., Zhong V.W., Rong S., et al. Physical frailty, adherence to ideal cardiovascular health and risk of cardiovascular disease: a prospective cohort study. Age Ageing. 2023; 52 (1): afac311. doi:10.1093/ageing/afac311</mixed-citation><mixed-citation xml:lang="en">Chen L., Li X., Lv Y., Tan X., Zhong V.W., Rong S., et al. Physical frailty, adherence to ideal cardiovascular health and risk of cardiovascular disease: a prospective cohort study. Age Ageing. 2023; 52 (1): afac311. doi:10.1093/ageing/afac311</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Travers J., Romero-Ortuno R., Langan J., MacNamara F., McCormack D., McDermott C., et al. Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults. Age Ageing. 2023; 52 (2): afad012. doi:10.1093/ ageing/afad012</mixed-citation><mixed-citation xml:lang="en">Travers J., Romero-Ortuno R., Langan J., MacNamara F., McCormack D., McDermott C., et al. Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults. Age Ageing. 2023; 52 (2): afad012. doi:10.1093/ ageing/afad012</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Quach J., Theou O., Pérez-Zepeda M.U., Godin J., Rockwood K., Kehler D.S. Effect of a physical activity intervention and frailty on frailty trajectory and major mobility disability. J Am Geriatr Soc. 2022; 70 (10): 2915-2924. doi:10.1111/jgs.17941</mixed-citation><mixed-citation xml:lang="en">Quach J., Theou O., Pérez-Zepeda M.U., Godin J., Rockwood K., Kehler D.S. Effect of a physical activity intervention and frailty on frailty trajectory and major mobility disability. J Am Geriatr Soc. 2022; 70 (10): 2915-2924. doi:10.1111/jgs.17941</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Кривошапова К.Е., Вегнер Е.А., Терентьева Н.А., Масенко В.Л., Григорьева И.И., Коков А.Н., и др. Синдром старческой астении у пациентов с ишемической болезнью сердца. Медицинский алфавит. 2020; 1 (19): 6-10. doi:10.33667/2078-5631-2020-19-6-10</mixed-citation><mixed-citation xml:lang="en">Krivoshapova K.E., Vegner E.A., Terentyeva N.A., Masenko V.L., Grigoryeva I.I., Kokov A.N., et al. Frailty syndrome in patients with coronary artery disease. Medical alphabet. 2020; 1 (19): 6-10. doi:10.33667/2078-5631-2020-19-6-10. (In Russ)</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Кривошапова К.Е., Барбараш О.Л., Вегнер Е.А., Зинец М.Г., Иванов С.В., Барбараш Л.С. Пациент с ишемической болезнью сердца и синдромом старческой астении: характеристика мультиморбидности и прогноз госпитального периода при проведении коронарного шунтирования. Грудная и сердечно-сосудистая хирургия. 2022; 64 (2): 161-168. doi:10.24022/0236-2791-2022-64-2-161-168</mixed-citation><mixed-citation xml:lang="en">Krivoshapova K.E., Barbarash O.L., Vegner E.A., Zinets M.G., Ivanov S.V., Barbarash L.S. The patient with ischemic heart disease and frailty syndrome: characteristics of multimorbidity and in-hospital prognosis after coronary artery bypass surgery. Russian journal of thoracic and cardiovascular surgery. 2022; 64 (2): 161-168. doi:10.24022/0236-2791-2022-64-2-161-168. (In Russ)</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ткачева О.Н., Котовская Ю.В., Рунихина Н.К., Фролова Е.В., Наумов А.В., Воробьева Н.М., и др. Клинические рекомендации «Старческая астения». Российский журнал гериатрической медицины. 2020; (1): 11-46. doi:10.37586/2686-8636-1-2020-11-46</mixed-citation><mixed-citation xml:lang="en">Tkacheva O.N., Kotovskaya Yu.V., Runikhina N.K., Frolova E.V., Naumov A.V., Vorobyeva N.M., et al. Clinical guidelines on frailty. Russian Journal of Geriatric Medicine. 2020; (1): 11-46. doi:10.37586/2686-8636-1-2020-11-46. (In Russ)</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Luo J., Carter G.C., Agarwal J.P., Kwok A.C. The 5-Factor Modified Frailty Index as a Predictor of 30-day Complications in Pressure Ulcer Repair. J Surg Res. 2021; 265: 21-26. doi:10.1016/j.jss.2021.03.011</mixed-citation><mixed-citation xml:lang="en">Luo J., Carter G.C., Agarwal J.P., Kwok A.C. The 5-Factor Modified Frailty Index as a Predictor of 30-day Complications in Pressure Ulcer Repair. J Surg Res. 2021; 265: 21-26. doi:10.1016/j.jss.2021.03.011</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Raîche M., Hébert R., Dubois M.F. PRISMA-7: a case-finding tool to identify older adults with moderate to severe disabilities. Arch Gerontol Geriatr. 2008; 47 (1): 9-18. doi:10.1016/j.archger.2007.06.004</mixed-citation><mixed-citation xml:lang="en">Raîche M., Hébert R., Dubois M.F. PRISMA-7: a case-finding tool to identify older adults with moderate to severe disabilities. Arch Gerontol Geriatr. 2008; 47 (1): 9-18. doi:10.1016/j.archger.2007.06.004</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J., et al. Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. The journals of gerontology. Series A. Biological sciences and medical sciences. 2001; 56 (3): M146-56. doi:10.1093/gerona/56.3.m146</mixed-citation><mixed-citation xml:lang="en">Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J., et al. Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. The journals of gerontology. Series A. Biological sciences and medical sciences. 2001; 56 (3): M146-56. doi:10.1093/gerona/56.3.m146</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Кривошапова К.Е., Цыганков Д.А., Цыганкова Д.П., Барбараш О.Л. Распространенность преастении и синдрома старческой астении у пациентов с многососудистым поражением коронарного русла. Комплексные проблемы сердечно-сосудистых заболеваний. 2023; 12 (4S): 25-33. doi:10.17802/2306-1278-2023-12-4S-25-33</mixed-citation><mixed-citation xml:lang="en">Krivoshapova K.E., Tsygankov D.A., Tsygankova D.P., Barbarash O.L. Prevalence of pre-frailty and frailty in patients with multivessel coronary artery disease. Complex Issues of Cardiovascular Diseases. 2023; 12 (4S): 25-33. doi:10.17802/2306-1278-2023-12-4S-25-33. (In Russ)</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Fogg C., Fraser S.D.S., Roderick P., de Lusignan S., Clegg A., Brailsford S., et al. The dynamics of frailty development and progression in older adults in primary care in England (2006-2017): a retrospective cohort profile. BMC Geriatr. 2022; 22 (1): 30. doi:10.1186/s12877-021-02684-y</mixed-citation><mixed-citation xml:lang="en">Fogg C., Fraser S.D.S., Roderick P., de Lusignan S., Clegg A., Brailsford S., et al. The dynamics of frailty development and progression in older adults in primary care in England (2006-2017): a retrospective cohort profile. BMC Geriatr. 2022; 22 (1): 30. doi:10.1186/s12877-021-02684-y</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshizawa Y., Tanaka T., Takahashi K., Fujisaki-Sueda-Sakai M., Son B.K., Iijima K. Impact of Health Literacy on the Progression of Frailty after 4 Years among Community-Dwelling Older Adults. Int J Environ Res Public Health. 2021; 19 (1): 394. doi:10.3390/ijerph19010394</mixed-citation><mixed-citation xml:lang="en">Yoshizawa Y., Tanaka T., Takahashi K., Fujisaki-Sueda-Sakai M., Son B.K., Iijima K. Impact of Health Literacy on the Progression of Frailty after 4 Years among Community-Dwelling Older Adults. Int J Environ Res Public Health. 2021; 19 (1): 394. doi:10.3390/ijerph19010394</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Xue Q.L., Bandeen-Roche K., Tian J., Kasper J.D., Fried L.P. Progression of Physical Frailty and the Risk of All-Cause Mortality: Is There a Point of No Return? J Am Geriatr Soc. 2021; 69 (4): 908-915. doi:10.1111/jgs.16976</mixed-citation><mixed-citation xml:lang="en">Xue Q.L., Bandeen-Roche K., Tian J., Kasper J.D., Fried L.P. Progression of Physical Frailty and the Risk of All-Cause Mortality: Is There a Point of No Return? J Am Geriatr Soc. 2021; 69 (4): 908-915. doi:10.1111/jgs.16976</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Goodman-Palmer D., Greig C., Agyapong-Badu S., Witham M.D., Payne C.F., Bountogo M., et al. Frailty progression in adults aged 40 years and older in rural Burkina Faso: a longitudinal, population-based study. Lancet Healthy Longev. 2024; 5 (7): e493-e502. doi:10.1016/S2666-7568(24)00096-5</mixed-citation><mixed-citation xml:lang="en">Goodman-Palmer D., Greig C., Agyapong-Badu S., Witham M.D., Payne C.F., Bountogo M., et al. Frailty progression in adults aged 40 years and older in rural Burkina Faso: a longitudinal, population-based study. Lancet Healthy Longev. 2024; 5 (7): e493-e502. doi:10.1016/S2666-7568(24)00096-5</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ye B., Li Y., Bao Z., Gao J. Psychological Resilience and Frailty Progression in Older Adults. JAMA Netw Open. 2024; 7 (11): e2447605. doi:10.1001/jamanetworkopen.2024.47605</mixed-citation><mixed-citation xml:lang="en">Ye B., Li Y., Bao Z., Gao J. Psychological Resilience and Frailty Progression in Older Adults. JAMA Netw Open. 2024; 7 (11): e2447605. doi:10.1001/jamanetworkopen.2024.47605</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">He D., Wang Z., Li J., Yu K., He Y., He X., et al. Changes in frailty and incident cardiovascular disease in three prospective cohorts. Eur Heart J. 2024; 45 (12): 1058-1068. doi:10.1093/eurheartj/ehad885</mixed-citation><mixed-citation xml:lang="en">He D., Wang Z., Li J., Yu K., He Y., He X., et al. Changes in frailty and incident cardiovascular disease in three prospective cohorts. Eur Heart J. 2024; 45 (12): 1058-1068. doi:10.1093/eurheartj/ehad885</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Gong Y., Song Y., Xu J., Dong H., Kramer D.B., Orkaby A.R., et al. Progression of frailty and cardiovascular outcomes among Medicare beneficiaries. J Am Geriatr Soc. 2024; 72 (10): 3129-3139. doi:10.1111/jgs.19116</mixed-citation><mixed-citation xml:lang="en">Gong Y., Song Y., Xu J., Dong H., Kramer D.B., Orkaby A.R., et al. Progression of frailty and cardiovascular outcomes among Medicare beneficiaries. J Am Geriatr Soc. 2024; 72 (10): 3129-3139. doi:10.1111/jgs.19116</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Howrey B.T., Al Snih S., Middleton J.A., Ottenbacher K.J. Trajectories of Frailty and Cognitive Decline Among Older Mexican Americans. J Gerontol A Biol Sci Med Sci. 2020; 75 (8): 1551-1557. doi:10.1093/gerona/glz295</mixed-citation><mixed-citation xml:lang="en">Howrey B.T., Al Snih S., Middleton J.A., Ottenbacher K.J. Trajectories of Frailty and Cognitive Decline Among Older Mexican Americans. J Gerontol A Biol Sci Med Sci. 2020; 75 (8): 1551-1557. doi:10.1093/gerona/glz295</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Ke Z., Wen H., Huang R., Xu X., Yang K., Liu W., et al. Long-term insulin resistance is associated with frailty, frailty progression, and cardiovascular disease. J Cachexia Sarcopenia Muscle. 2024; 15 (4): 1578-1586. doi:10.1002/jcsm.13516</mixed-citation><mixed-citation xml:lang="en">Ke Z., Wen H., Huang R., Xu X., Yang K., Liu W., et al. Long-term insulin resistance is associated with frailty, frailty progression, and cardiovascular disease. J Cachexia Sarcopenia Muscle. 2024; 15 (4): 1578-1586. doi:10.1002/jcsm.13516</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
