kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”kpccz-1714Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОРANALYTICAL REVIEWSORBS2 КАК НОВАЯ МОЛЕКУЛЯРНАЯ МИШЕНЬ В ДИАГНОСТИКЕ И ЛЕЧЕНИИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙSORBS2 AS A NOVEL MOLECULAR TARGET IN THE DIAGNOSIS AND TREATMENT OF CARDIOVASCULAR DISEASEShttps://orcid.org/0009-0002-0825-1245АтоянАртем ГригорьевичAtoyanArtem G.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ростов-на-Дону, Российская Федерация

Student, Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation, Rostov-on-Don, Russian Federation

https://orcid.org/0009-0003-3701-7607ЖолковскаяМаргарита АлександровнаZholkovskayaMargarita A.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ростов-на-Дону, Российская Федерация

Student, Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation, Rostov-on-Don, Russian Federation

https://orcid.org/0009-0007-0316-160XСавлоховаАмина АхметовнаSavlokhovaAmina A.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Северо-Осетинская государственная медицинская академия» Министерства здравоохранения Российской Федерации, Владикавказ, Российская Федерация

Student, North Ossetian State Medical Academy, Vladikavkaz, Russian Federation

https://orcid.org/0009-0000-5633-3232ТоряникАнастасия СергеевнаToryanikAnastasia S.

врач-терапевт государственного бюджетного учреждения Ростовской области «Городская больница №6» в г. Ростове-на-Дону, Ростов-на-Дону, Российская Федерация

therapist, State Budgetary Institution of the Rostov Region “City Hospital No. 6” in Rostov-on-Don, Rostov-on-Don, Russian Federation

toryashechka997@gmail.comhttps://orcid.org/0009-0001-1649-0871МамаеваУмсайтин МурадовнаMamaevaUmsaitin M.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Астраханский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Астрахань, Российская Федерация

Student, Federal State Budgetary Educational Institution of Higher Education “Astrakhan State Medical University” of the Ministry of Healthcare of the Russian Federation, Astrakhan, Russian Federation

https://orcid.org/0009-0009-8798-2476БелиевАхмед АлимпашаевичBelievAkhmed A.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ставрополь, Российская Федерация

Student, Stavropol State Medical University, Stavropol, Russian Federation

https://orcid.org/0009-0009-2792-1380ХатукаевАмир ХасановичKhatukaevAmir Kh.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ставрополь, Российская Федерация

Student, Stavropol State Medical University, Stavropol, Russian Federation

https://orcid.org/0009-0000-5133-0294БорлаковаСаида МаратовнаBorlakovaSaida M.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ставрополь, Российская Федерация

Student, Stavropol State Medical University, Stavropol, Russian Federation

https://orcid.org/0009-0006-1271-8046АрапиеваЛуиза АлихановнаArapievaLuiza A.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ростов-на-Дону, Российская Федерация

Student, Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation, Rostov-on-Don, Russian Federation

https://orcid.org/0009-0003-6101-4756РочеваАнастасия ДмитриевнаRochevaAnastasia D.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ростов-на-Дону, Российская Федерация

Student, Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation, Rostov-on-Don, Russian Federation

https://orcid.org/0009-0008-5729-2389ГороховаДарья ДенисовнаGorokhovaDaria D.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ростов-на-Дону, Российская Федерация

Student, Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation, Rostov-on-Don, Russian Federation

https://orcid.org/0009-0003-4095-6402ОкуловСавелий АлександровичOkulovSavely A.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ростов-на-Дону, Российская Федерация

Student, Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation, Rostov-on-Don, Russian Federation

https://orcid.org/0009-0009-5361-8641НасоновИлья ГеннадьевичNasonovIlya G.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ростов-на-Дону, Российская Федерация

Student, Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation, Rostov-on-Don, Russian Federation

https://orcid.org/0009-0009-5618-6856КорчмарьКсения ВадимовнаKorchmarKseniya V.

студент федерального государственного бюджетного образовательного учреждения высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Ростов-на-Дону, Российская Федерация

Student, Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation, Rostov-on-Don, Russian Federation

Федеральное государственное бюджетное образовательное учреждение высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian FederationRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Северо-Осетинская государственная медицинская академия» Министерства здравоохранения Российской ФедерацииРоссияNorth Ossetian State Medical AcademyRussian FederationГосударственное бюджетное учреждение Ростовской области «Городская больница №6» в г. Ростове-на-ДонуРоссияState Budgetary Institution of the Rostov Region “City Hospital No. 6” in Rostov-on-DonRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Астраханский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education “Astrakhan State Medical University” of the Ministry of Healthcare of the Russian FederationRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияStavropol State Medical UniversityRussian Federation20210408202500Online First1714Copyright © Атоян А.Г., Жолковская М.А., Савлохова А.А., Торяник А.С., Мамаева У.М., Белиев А.А., Хатукаев А.Х., Борлакова С.М., Арапиева Л.А., Рочева А.Д., Горохова Д.Д., Окулов С.А., Насонов И.Г., Корчмарь К.В., 20212021Атоян А.Г., Жолковская М.А., Савлохова А.А., Торяник А.С., Мамаева У.М., Белиев А.А., Хатукаев А.Х., Борлакова С.М., Арапиева Л.А., Рочева А.Д., Горохова Д.Д., Окулов С.А., Насонов И.Г., Корчмарь К.В.Atoyan A.G., Zholkovskaya M.A., Savlokhova A.A., Toryanik A.S., Mamaeva U.M., Believ A.A., Khatukaev A.K., Borlakova S.M., Arapieva L.A., Rocheva A.D., Gorokhova D.D., Okulov S.A., Nasonov I.G., Korchmar K.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/1714Основные положения

Основные положения

 

 

Резюме

Резюме

Белок 2, содержащий сорбин и SH3-домен (Sorbs2), представляет собой мультифункциональный адаптерный белок, играющий ключевую роль в регуляции клеточной архитектуры, передачи сигналов и экспрессии генов в сердечно-сосудистой системе. Sorbs2 высоко экспрессируется в кардиомиоцитах, гладкомышечных клетках сосудов и эндотелии, обеспечивая как механическую стабильность, так и электрическую возбудимость сердечной ткани. Последние исследования показали, что Sorbs2 участвует в патогенезе широкого спектра сердечно-сосудистых заболеваний, включая дислипидемию, атеросклероз, артериальную гипертензию, кардиомиопатии, аритмии, фибрилляцию предсердий, врождённые пороки сердца, диабетическую васкулопатию и аневризмы аорты. Кроме своей роли как компонента цитоскелета, Sorbs2 функционирует как РНК-связывающий белок, регулирующий стабильность и трансляцию мРНК, кодирующих ионные каналы и белки межклеточных контактов, критически важных для сердечной проводимости. Нарушение регуляции Sorbs2 ассоциировано с развитием фиброза, ремоделированием предсердий и снижением сократительной функции миокарда. При этом данные о его роли в воспалении носят противоречивый характер, что подчёркивает необходимость дальнейших исследований. Настоящий обзор обобщает существующие данные о молекулярной биологии Sorbs2, его регуляторных механизмах и патофизиологической значимости в контексте сердечно-сосудистых заболеваний. Рассматривается потенциал Sorbs2 как диагностического биомаркера и перспективной терапевтической мишени. Углублённое изучение Sorbs2 может открыть новые возможности для персонализированной медицины и целенаправленного лечения сердечно-сосудистой патологии.

Highlights      

Highlights      

           

           

Abstract

Abstract

Sorbin and SH3 domain-containing protein 2 (Sorbs2) is a multifunctional adaptor protein that plays a key role in regulating cellular architecture, signal transduction, and gene expression in the cardiovascular system. Sorbs2 is highly expressed in cardiomyocytes, vascular smooth muscle cells, and endothelial cells, contributing to both the mechanical stability and electrical excitability of cardiac tissue. Recent studies have demonstrated that Sorbs2 is involved in the pathogenesis of a wide range of cardiovascular diseases, including dyslipidemia, atherosclerosis, hypertension, cardiomyopathies, arrhythmias, atrial fibrillation, congenital heart defects, diabetic vasculopathy, and aortic aneurysms. Beyond its structural role as part of the cytoskeleton, Sorbs2 functions as an RNA-binding protein that regulates the stability and translation of mRNAs encoding proteins of ion channels and intercellular junctions, which are essential for cardiac conduction.. Dysregulation of Sorbs2 has been associated with myocardial fibrosis, atrial remodeling, and impaired cardiac contractility. Notably, the data on its role in inflammation are contradictory, highlighting the need for further investigation. This review summarizes current knowledge on the molecular biology of Sorbs2, its regulatory mechanisms, and its pathophysiological relevance in the context of cardiovascular diseases. The potential of Sorbs2 as a diagnostic biomarker and therapeutic target is discussed. A deeper understanding of Sorbs2 may open new avenues for personalized medicine and targeted treatment strategies in cardiovascular pathology.

Sorbs2Сердечно-сосудистые заболеванияРНК-связывающие белкиРемоделирование сердцаИонные каналыФибрилляция предсердийТерапевтическая мишеньSorbs2Cardiovascular diseasesRNA-binding proteinsCardiac remodelingIon channelsAtrial fibrillationTherapeutic targetАвторы заявляют об отсутствии финансирования исследования.ReferencesMensah GA, Fuster V, Roth GA. A Heart-Healthy and Stroke-Free World: Using Data to Inform Global Action. J Am Coll Cardiol. 2023;82(25):2343-2349. doi: 10.1016/j.jacc.2023.11.003.Mensah GA, Fuster V, Roth GA. A Heart-Healthy and Stroke-Free World: Using Data to Inform Global Action. J Am Coll Cardiol. 2023;82(25):2343-2349. doi: 10.1016/j.jacc.2023.11.003.Косолапов ВП, Ярмонова МВ. Анализ высокой сердечно-сосудистой заболеваемости и смертности взрослого населения как медико-социальной проблемы и поиск путей ее решения. Уральский медицинский журнал. 2021;20(1):58-64. https://doi.org/10.52420/2071-5943-2021-20-1-58-64Kosolapov VP, Yarmonova MV. The analysis of high cardiovascular morbidity and mortality in the adult population as a medical and social problem and the search for ways to solve it. Ural Medical Journal. 2021;20(1):58-64. (In Russ.) https://doi.org/10.52420/2071-5943-2021-20-1-58-64Боровкова Н.Ю., Токарева А.С., Савицкая Н.Н., и др. Современное состояние проблемы сердечно-сосудистых заболеваний в Нижегородском регионе: возможные пути снижения смертности. Российский кардиологический журнал. 2022;27(5):5024. https://doi.org/10.15829/1560-4071-2022-5024Borovkova N.Yu., Tokareva A.S., Savitskaya N.N., et al. Current status of the problem of cardiovascular diseases in the Nizhny Novgorod region: possible ways to reduce mortality. Russian Journal of Cardiology. 2022;27(5):5024. (In Russ.) https://doi.org/10.15829/1560-4071-2022-5024Фозилов Х.Г., Атаниязов Х.Х., Хамидуллаева Г.А., и др. Раннее выявление и контроль факторов риска сердечно-сосудистых заболеваний в приаралье: опыт Узбекистана. Кардиология. 2024;64(1):37-43. https://doi.org/10.18087/cardio.2024.1.n2614Fozilov H.G., Ataniyazov H.H., Khamidullaeva G.A., et al. Early Detection and Control of Risk Factors for Cardiovascular Diseases in the Aral Region: Experience of Uzbekistan. Kardiologiia. 2024;64(1):37-43. https://doi.org/10.18087/cardio.2024.1.n2614Li C, Zheng Y, Liu Y, et al. The interaction protein of SORBS2 in myocardial tissue to find out the pathogenic mechanism of LVNC disease. Aging (Albany NY). 2022;14(2):800-810. doi: 10.18632/aging.203841Li C, Zheng Y, Liu Y, et al. The interaction protein of SORBS2 in myocardial tissue to find out the pathogenic mechanism of LVNC disease. Aging (Albany NY). 2022;14(2):800-810. doi: 10.18632/aging.203841Zhang S, Tong Y. Advances in the previous two decades in our understanding of the post-translational modifications, functions, and drug perspectives of ArgBP2 and its family members. Biomed Pharmacother. 2022;155:113853. doi: 10.1016/j.biopha.2022.113853.Zhang S, Tong Y. Advances in the previous two decades in our understanding of the post-translational modifications, functions, and drug perspectives of ArgBP2 and its family members. Biomed Pharmacother. 2022;155:113853. doi: 10.1016/j.biopha.2022.113853.Jaufmann J, Franke FC, Sperlich A, et al. The emerging and diverse roles of the SLy/SASH1-protein family in health and disease-Overview of three multifunctional proteins. FASEB J. 2021;35(4):e21470. doi: 10.1096/fj.202002495R.Jaufmann J, Franke FC, Sperlich A, et al. The emerging and diverse roles of the SLy/SASH1-protein family in health and disease-Overview of three multifunctional proteins. FASEB J. 2021;35(4):e21470. doi: 10.1096/fj.202002495R.Ichikawa T, Kita M, Matsui TS, et al. Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation. J Cell Sci. 2017;130(20):3517-3531. doi: 10.1242/jcs.200691.Ichikawa T, Kita M, Matsui TS, et al. Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation. J Cell Sci. 2017;130(20):3517-3531. doi: 10.1242/jcs.200691.Bai Y, Wang H, Li C. SAPAP Scaffold Proteins: From Synaptic Function to Neuropsychiatric Disorders. Cells. 2022;11(23):3815. doi: 10.3390/cells11233815.Bai Y, Wang H, Li C. SAPAP Scaffold Proteins: From Synaptic Function to Neuropsychiatric Disorders. Cells. 2022;11(23):3815. doi: 10.3390/cells11233815.Murase K, Ito H, Kanoh H, et al. Cell biological characterization of a multidomain adaptor protein, ArgBP2, in epithelial NMuMG cells, and identification of a novel short isoform. Med Mol Morphol. 2012;45(1):22-8. doi: 10.1007/s00795-010-0537-9.Murase K, Ito H, Kanoh H, et al. Cell biological characterization of a multidomain adaptor protein, ArgBP2, in epithelial NMuMG cells, and identification of a novel short isoform. Med Mol Morphol. 2012;45(1):22-8. doi: 10.1007/s00795-010-0537-9.Zhang Q, Gao X, Li C, et al. Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. J Neurosci. 2016;36(7):2247-60. doi: 10.1523/JNEUROSCI.2528-15.2016.Zhang Q, Gao X, Li C, et al. Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. J Neurosci. 2016;36(7):2247-60. doi: 10.1523/JNEUROSCI.2528-15.2016.Borowicz P, Chan H, Hauge A, Spurkland A. Adaptor proteins: Flexible and dynamic modulators of immune cell signalling. Scand J Immunol. 2020;92(5):e12951. doi: 10.1111/sji.12951.Borowicz P, Chan H, Hauge A, Spurkland A. Adaptor proteins: Flexible and dynamic modulators of immune cell signalling. Scand J Immunol. 2020;92(5):e12951. doi: 10.1111/sji.12951.GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)–Analysis Working Group; Statistical Methods groups–Analysis Working Group; Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH/NCI; NIH/NHGRI; NIH/NIMH; NIH/NIDA; Biospecimen Collection Source Site–NDRI; Biospecimen Collection Source Site–RPCI; Biospecimen Core Resource–VARI; Brain Bank Repository–University of Miami Brain Endowment Bank; Leidos Biomedical–Project Management; ELSI Study; Genome Browser Data Integration &Visualization–EBI; Genome Browser Data Integration &Visualization–UCSC Genomics Institute, University of California Santa Cruz; Lead analysts:; Laboratory, Data Analysis &Coordinating Center (LDACC):; NIH program management:; Biospecimen collection:; Pathology:; eQTL manuscript working group:; Battle A, Brown CD, Engelhardt BE, Montgomery SB. Genetic effects on gene expression across human tissues. Nature. 2017;550(7675):204-213. doi: 10.1038/nature24277.GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)–Analysis Working Group; Statistical Methods groups–Analysis Working Group; Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH/NCI; NIH/NHGRI; NIH/NIMH; NIH/NIDA; Biospecimen Collection Source Site–NDRI; Biospecimen Collection Source Site–RPCI; Biospecimen Core Resource–VARI; Brain Bank Repository–University of Miami Brain Endowment Bank; Leidos Biomedical–Project Management; ELSI Study; Genome Browser Data Integration &Visualization–EBI; Genome Browser Data Integration &Visualization–UCSC Genomics Institute, University of California Santa Cruz; Lead analysts:; Laboratory, Data Analysis &Coordinating Center (LDACC):; NIH program management:; Biospecimen collection:; Pathology:; eQTL manuscript working group:; Battle A, Brown CD, Engelhardt BE, Montgomery SB. Genetic effects on gene expression across human tissues. Nature. 2017;550(7675):204-213. doi: 10.1038/nature24277.Lv Q, Dong F, Zhou Y, et al. RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability. Cell Death Dis. 2020;11(12):1056. doi: 10.1038/s41419-020-03268-1.Lv Q, Dong F, Zhou Y, et al. RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability. Cell Death Dis. 2020;11(12):1056. doi: 10.1038/s41419-020-03268-1.Ding Y, Yang J, Chen P, et al. Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy. J Am Heart Assoc. 2020;9(17):e017055. doi: 10.1161/JAHA.119.017055.Ding Y, Yang J, Chen P, et al. Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy. J Am Heart Assoc. 2020;9(17):e017055. doi: 10.1161/JAHA.119.017055.Sanger JM, Wang J, Gleason LM, et al. Arg/Abl-binding protein, a Z-body and Z-band protein, binds sarcomeric, costameric, and signaling molecules. Cytoskeleton (Hoboken). 2010;67(12):808-23. doi: 10.1002/cm.20490.Sanger JM, Wang J, Gleason LM, et al. Arg/Abl-binding protein, a Z-body and Z-band protein, binds sarcomeric, costameric, and signaling molecules. Cytoskeleton (Hoboken). 2010;67(12):808-23. doi: 10.1002/cm.20490.Qian LL, Sun X, Yang J, et al. Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2. Biochim Biophys Acta Mol Basis Dis. 2021;1867(12):166247. doi: 10.1016/j.bbadis.2021.166247.Qian LL, Sun X, Yang J, et al. Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2. Biochim Biophys Acta Mol Basis Dis. 2021;1867(12):166247. doi: 10.1016/j.bbadis.2021.166247.Sun X, Lee HC, Lu T. Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes. Circ Res. 2024;134(7):858-871. doi: 10.1161/CIRCRESAHA.123.323538.Sun X, Lee HC, Lu T. Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes. Circ Res. 2024;134(7):858-871. doi: 10.1161/CIRCRESAHA.123.323538.Zhao L, Wang W, Huang S, et al. The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts. Genome Biol. 2018;19(1):35. doi: 10.1186/s13059-018-1412-6.Zhao L, Wang W, Huang S, et al. The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts. Genome Biol. 2018;19(1):35. doi: 10.1186/s13059-018-1412-6.Van Nostrand EL, Freese P, Pratt GA, et al. A large-scale binding and functional map of human RNA-binding proteins. Nature. 2020;583(7818):711-719. doi: 10.1038/s41586-020-2077-3.Van Nostrand EL, Freese P, Pratt GA, et al. A large-scale binding and functional map of human RNA-binding proteins. Nature. 2020;583(7818):711-719. doi: 10.1038/s41586-020-2077-3.Gebauer F, Schwarzl T, Valcárcel J, Hentze MW. RNA-binding proteins in human genetic disease. Nat Rev Genet. 2021;22(3):185-198. doi: 10.1038/s41576-020-00302-y.Gebauer F, Schwarzl T, Valcárcel J, Hentze MW. RNA-binding proteins in human genetic disease. Nat Rev Genet. 2021;22(3):185-198. doi: 10.1038/s41576-020-00302-y.Timmer LT, den Hertog E, Versteeg D, et al. Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition. Cardiovasc Res. 2025;121(4):585-600. doi: 10.1093/cvr/cvaf021.Timmer LT, den Hertog E, Versteeg D, et al. Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition. Cardiovasc Res. 2025;121(4):585-600. doi: 10.1093/cvr/cvaf021.Dovinova I, Kvandová M, Balis P, et al. The role of Nrf2 and PPARgamma in the improvement of oxidative stress in hypertension and cardiovascular diseases. Physiol Res. 2020;69(Suppl 4):S541-S553. doi: 10.33549/physiolres.934612.Dovinova I, Kvandová M, Balis P, et al. The role of Nrf2 and PPARgamma in the improvement of oxidative stress in hypertension and cardiovascular diseases. Physiol Res. 2020;69(Suppl 4):S541-S553. doi: 10.33549/physiolres.934612.Zhu L, Choudhary K, Gonzalez-Teran B, et al. Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors. Circulation. 2022;146(10):770-787. doi: 10.1161/CIRCULATIONAHA.121.057620.Zhu L, Choudhary K, Gonzalez-Teran B, et al. Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors. Circulation. 2022;146(10):770-787. doi: 10.1161/CIRCULATIONAHA.121.057620.Lu T, Sun X, Li Y, et al. Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice. Diabetes. 2017;66(10):2681-2690. doi: 10.2337/db17-0181.Lu T, Sun X, Li Y, et al. Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice. Diabetes. 2017;66(10):2681-2690. doi: 10.2337/db17-0181.Gutiérrez-Cuevas J, Galicia-Moreno M, Monroy-Ramírez HC, et al. The Role of NRF2 in Obesity-Associated Cardiovascular Risk Factors. Antioxidants (Basel). 2022; 11(2):235. doi: 10.3390/antiox11020235.Gutiérrez-Cuevas J, Galicia-Moreno M, Monroy-Ramírez HC, et al. The Role of NRF2 in Obesity-Associated Cardiovascular Risk Factors. Antioxidants (Basel). 2022; 11(2):235. doi: 10.3390/antiox11020235.Артеменков АА. Дислипидемии плазмы крови: патогенез и диагностическое значение. Обзор литературы. Пермский медицинский журнал (сетевое издание "Perm medical journal"). 2023;40(1):78-93. doi: 10.17816/pmj40178-93Artemenkov AA. Plasma dyslipidemia: pathogenesis and diagnostic value. Literature review. Perm Medical Journal. 2023;40(1):78-93 (In Russ.) doi: 10.17816/pmj40178-93Liu MM, Peng J, Guo YL, et al. SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia. J Transl Med. 2022;20(1):233. doi: 10.1186/s12967-022-03381-z.Liu MM, Peng J, Guo YL, et al. SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia. J Transl Med. 2022;20(1):233. doi: 10.1186/s12967-022-03381-z.Feng X, Yu W, Li X, et al. Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. Biochem Pharmacol. 2017 Jul 15;136:136-149. doi: 10.1016/j.bcp.2017.04.014.Feng X, Yu W, Li X, et al. Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. Biochem Pharmacol. 2017 Jul 15;136:136-149. doi: 10.1016/j.bcp.2017.04.014.Ren K, Li H, Zhou HF, et al. Mangiferin promotes macrophage cholesterol efflux and protects against atherosclerosis by augmenting the expression of ABCA1 and ABCG1. Aging (Albany NY). 2019;11(23):10992-11009. doi: 10.18632/aging.102498.Ren K, Li H, Zhou HF, et al. Mangiferin promotes macrophage cholesterol efflux and protects against atherosclerosis by augmenting the expression of ABCA1 and ABCG1. Aging (Albany NY). 2019;11(23):10992-11009. doi: 10.18632/aging.102498.Jiang M, Li X. Activation of PPARγ does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI. Biochem Biophys Res Commun. 2017;482(4):849-856. doi: 10.1016/j.bbrc.2016.11.123.Jiang M, Li X. Activation of PPARγ does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI. Biochem Biophys Res Commun. 2017;482(4):849-856. doi: 10.1016/j.bbrc.2016.11.123.Калашников В.Ю., Мичурова М.С. Атеросклеротические сердечно-сосудистые заболевания и сахарный диабет 2‑го типа. Как учесть все нюансы в выборе терапии? Кардиология. 2021;61(1):78-86. https://doi.org/10.18087/cardio.2021.1.n1148Kalashnikov V.Y., Michurova M.S. Atherosclerotic Cardiovascular Diseases and Type 2 Diabetes Mellitus – new Developments in the Treatment. Kardiologiia. 2021;61(1):78-86. (In Russ.) https://doi.org/10.18087/cardio.2021.1.n1148Xiong X, Zhou J, Fu Q, et al. The associations between TMAO-related metabolites and blood lipids and the potential impact of rosuvastatin therapy. Lipids Health Dis. 2022;21(1):60. doi: 10.1186/s12944-022-01673-3.Xiong X, Zhou J, Fu Q, et al. The associations between TMAO-related metabolites and blood lipids and the potential impact of rosuvastatin therapy. Lipids Health Dis. 2022;21(1):60. doi: 10.1186/s12944-022-01673-3.Каширских Д.А., Хотина В.А., Сухоруков В.Н., и др. Клеточные и тканевые маркеры атеросклероза. Комплексные проблемы сердечно-сосудистых заболеваний. 2020;9(2):102-113. https://doi.org/10.17802/2306-1278-2020-9-2-102-113Kashirskikh D.A., Khotina V.A., Sukhorukov V.N., et al. Cell and tissue markers of atherosclerosis. Complex Issues of Cardiovascular Diseases. 2020;9(2):102-113. (In Russ.) https://doi.org/10.17802/2306-1278-2020-9-2-102-113Geovanini GR, Libby P. Atherosclerosis and inflammation: overview and updates. Clin Sci (Lond). 2018;132(12):1243-1252. doi: 10.1042/CS20180306.Geovanini GR, Libby P. Atherosclerosis and inflammation: overview and updates. Clin Sci (Lond). 2018;132(12):1243-1252. doi: 10.1042/CS20180306.Zhu Y, Xian X, Wang Z, et al. Research Progress on the Relationship between Atherosclerosis and Inflammation. Biomolecules. 2018;8(3):80. doi: 10.3390/biom8030080.Zhu Y, Xian X, Wang Z, et al. Research Progress on the Relationship between Atherosclerosis and Inflammation. Biomolecules. 2018;8(3):80. doi: 10.3390/biom8030080.Badimon L, Peña E, Arderiu G, et al. C-Reactive Protein in Atherothrombosis and Angiogenesis. Front Immunol. 2018;9:430. doi: 10.3389/fimmu.2018.00430.Badimon L, Peña E, Arderiu G, et al. C-Reactive Protein in Atherothrombosis and Angiogenesis. Front Immunol. 2018;9:430. doi: 10.3389/fimmu.2018.00430.Akinyelure OP, Colantonio LD, Chaudhary NS, et al. Inflammation biomarkers and incident coronary heart disease: the Reasons for Geographic And Racial Differences in Stroke Study. Am Heart J. 2022;253:39-47. doi: 10.1016/j.ahj.2022.07.001Akinyelure OP, Colantonio LD, Chaudhary NS, et al. Inflammation biomarkers and incident coronary heart disease: the Reasons for Geographic And Racial Differences in Stroke Study. Am Heart J. 2022;253:39-47. doi: 10.1016/j.ahj.2022.07.001Kumari P, Kumar H. Dimensions of inflammation in host defense and diseases. Int Rev Immunol. 2022;41(1):1-3. doi: 10.1080/08830185.2022.2014174.Kumari P, Kumar H. Dimensions of inflammation in host defense and diseases. Int Rev Immunol. 2022;41(1):1-3. doi: 10.1080/08830185.2022.2014174.Vdovenko D, Bachmann M, Wijnen WJ, et al. The adaptor protein c-Cbl-associated protein (CAP) limits pro-inflammatory cytokine expression by inhibiting the NF-κB pathway. Int Immunopharmacol. 2020;87:106822. doi: 10.1016/j.intimp.2020.106822.Vdovenko D, Bachmann M, Wijnen WJ, et al. The adaptor protein c-Cbl-associated protein (CAP) limits pro-inflammatory cytokine expression by inhibiting the NF-κB pathway. Int Immunopharmacol. 2020;87:106822. doi: 10.1016/j.intimp.2020.106822.Bang C, Batkai S, Dangwal S, et al. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014;124(5):2136-46. doi: 10.1172/JCI70577.Bang C, Batkai S, Dangwal S, et al. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014;124(5):2136-46. doi: 10.1172/JCI70577.Wang H, Bei Y, Shen S, et al. miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. J Mol Cell Cardiol. 2016;94:43-53. doi: 10.1016/j.yjmcc.2016.03.014.Wang H, Bei Y, Shen S, et al. miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. J Mol Cell Cardiol. 2016;94:43-53. doi: 10.1016/j.yjmcc.2016.03.014.Shan B, Li JY, Liu YJ, et al. LncRNA H19 Inhibits the Progression of Sepsis-Induced Myocardial Injury via Regulation of the miR-93-5p/SORBS2 Axis. Inflammation. 2021;44(1):344-357. doi: 10.1007/s10753-020-01340-8.Shan B, Li JY, Liu YJ, et al. LncRNA H19 Inhibits the Progression of Sepsis-Induced Myocardial Injury via Regulation of the miR-93-5p/SORBS2 Axis. Inflammation. 2021;44(1):344-357. doi: 10.1007/s10753-020-01340-8.Алиева АМ, Алмазова ИИ, Резник ЕВ, и др. Гипертрофическая кардиомиопатия: современный взгляд на проблему. CardioСоматика. 2020;11(1):39-45. doi: 10.26442/22217185.2020.1.200116Алиева АМ, Алмазова ИИ, Резник ЕВ, и др. Гипертрофическая кардиомиопатия: современный взгляд на проблему. CardioСоматика. 2020;11(1):39-45. doi: 10.26442/22217185.2020.1.200116 [Alievа A.M., Almazova I.I., Reznik E.V. et al. Hypertrophic cardiomyopathy: a modern view of the problem. Cardiosomatics. 2020; 11 (1): 40–46. DOI: 10.26442/22217185.2020.1.200116]Галеева З.М., Галявич А.С., Балеева Л.В., и др. О причинах дилатационной кардиомиопатии в молодом возрасте. Южно-Российский журнал терапевтической практики. 2022;3(3):85-90. https://doi.org/10.21886/2712-8156-2022-3-3-85-90Galeeva Z.M., Galyavich A.S., Baleeva L.V., et al. About the сases of dilated cardiomyopathy. South Russian Journal of Therapeutic Practice. 2022;3(3):85-90. (In Russ.) https://doi.org/10.21886/2712-8156-2022-3-3-85-90McLendon JM, Zhang X, Matasic DS, et al. Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice. J Am Heart Assoc. 2022;11(13):e025687. doi: 10.1161/JAHA.122.025687.McLendon JM, Zhang X, Matasic DS, et al. Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice. J Am Heart Assoc. 2022;11(13):e025687. doi: 10.1161/JAHA.122.025687.Gagliano Taliun SA, VandeHaar P, Boughton AP, et al. Exploring and visualizing large-scale genetic associations by using PheWeb. Nat Genet. 2020;52(6):550-552. doi: 10.1038/s41588-020-0622-5.Gagliano Taliun SA, VandeHaar P, Boughton AP, et al. Exploring and visualizing large-scale genetic associations by using PheWeb. Nat Genet. 2020;52(6):550-552. doi: 10.1038/s41588-020-0622-5.Ashar FN, Mitchell RN, Albert CM, et al. A comprehensive evaluation of the genetic architecture of sudden cardiac arrest. Eur Heart J. 2018;39(44):3961-3969. doi: 10.1093/eurheartj/ehy474.Ashar FN, Mitchell RN, Albert CM, et al. A comprehensive evaluation of the genetic architecture of sudden cardiac arrest. Eur Heart J. 2018;39(44):3961-3969. doi: 10.1093/eurheartj/ehy474.Li C, Liu F, Liu S, et al. Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy. EBioMedicine. 2020;53:102695. doi: 10.1016/j.ebiom.2020.102695.Li C, Liu F, Liu S, et al. Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy. EBioMedicine. 2020;53:102695. doi: 10.1016/j.ebiom.2020.102695.Li C, Zhang L, Hu X, et al. SORBS2 upregulation may contribute to dysfunction in LVNC via the Notch pathway. Acta Biochim Biophys Sin (Shanghai). 2022;55(2):327-329. doi: 10.3724/abbs.2022177Li C, Zhang L, Hu X, et al. SORBS2 upregulation may contribute to dysfunction in LVNC via the Notch pathway. Acta Biochim Biophys Sin (Shanghai). 2022;55(2):327-329. doi: 10.3724/abbs.2022177Guo A, Wang Y, Chen B, et al. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018;362(6421):eaan3303. doi: 10.1126/science.aan3303Guo A, Wang Y, Chen B, et al. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018;362(6421):eaan3303. doi: 10.1126/science.aan3303Prins KW, Asp ML, Zhang H, et al. Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice. JACC Basic Transl Sci. 2016;1(3):122-130. doi: 10.1016/j.jacbts.2016.02.002Prins KW, Asp ML, Zhang H, et al. Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice. JACC Basic Transl Sci. 2016;1(3):122-130. doi: 10.1016/j.jacbts.2016.02.002Халиков А.А., Кузнецов К.О., Искужина Л.Р., Халикова Л.В. Судебно-медицинские аспекты внезапной аутопсия-отрицательной сердечной смерти. Судебно-медицинская экспертиза. 2021;64(3):59‑63. https://doi.org/10.17116/sudmed20216403159Khalikov AA, Kuznetsov KO, Iskuzhina LR, Khalikova LV. Forensic aspects of sudden autopsy-negative cardiac death. Forensic Medical Expertise. 2021;64(3):59‑63. (In Russ.) https://doi.org/10.17116/sudmed20216403159Петрова Е.А., Кольцова Е.А. Нарушения ритма сердца и инсульт. Consilium Medicum. 2017; 19 (2): 30–34.Petrova E.A., KoltsovaE.A. Cardiac arrhythmias and stroke. Consilium Medicum. 2017; 19 (2):30–34 (In Russ.).Канорский С.Г. Фибрилляция предсердий в старческом возрасте: современные возможности лечения. Южно-Российский журнал терапевтической практики. 2022;3(1):7-14. https://doi.org/10.21886/2712-8156-2022-3-1-7-14Kanorskii S.G. Atrial fibrillation in old age: current treatment options. South Russian Journal of Therapeutic Practice. 2022;3(1):7-14. (In Russ.) https://doi.org/10.21886/2712-8156-2022-3-1-7-14Антипов Г.Н., Постол А.С., Котов С.Н., и др. Сравнение ремоделирования предсердий после процедур «лабиринт-3» и «криолабиринт» при сочетанных вмешательствах на сердце: ретроспективное исследование. Кубанский научный медицинский вестник. 2022;29(2):14-27. https://doi.org/10.25207/1608-6228-2022-29-2-14-27Antipov G.N., Postol A.S., Kotov S.N., et al. Atrial remodelling comparison after maze-3 and cryo-maze procedures in combined cardiac interventions: a retrospective study. Kuban Scientific Medical Bulletin. 2022;29(2):14-27. https://doi.org/10.25207/1608-6228-2022-29-2-14-27Nattel S, Dobrev D. Controversies About Atrial Fibrillation Mechanisms: Aiming for Order in Chaos and Whether it Matters. Circ Res. 2017 ;120(9):1396-1398. doi: 10.1161/CIRCRESAHA.116.310489.Nattel S, Dobrev D. Controversies About Atrial Fibrillation Mechanisms: Aiming for Order in Chaos and Whether it Matters. Circ Res. 2017 ;120(9):1396-1398. doi: 10.1161/CIRCRESAHA.116.310489.Nielsen JB, Thorolfsdottir RB, Fritsche LG, et al. Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. Nat Genet. 2018;50(9):1234-1239. doi: 10.1038/s41588-018-0171-3.Nielsen JB, Thorolfsdottir RB, Fritsche LG, et al. Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. Nat Genet. 2018;50(9):1234-1239. doi: 10.1038/s41588-018-0171-3.Roselli C, Rienstra M, Ellinor PT. Genetics of Atrial Fibrillation in 2020: GWAS, Genome Sequencing, Polygenic Risk, and Beyond. Circ Res. 2020;127(1):21-33. doi: 10.1161/CIRCRESAHA.120.316575.Roselli C, Rienstra M, Ellinor PT. Genetics of Atrial Fibrillation in 2020: GWAS, Genome Sequencing, Polygenic Risk, and Beyond. Circ Res. 2020;127(1):21-33. doi: 10.1161/CIRCRESAHA.120.316575.Kim JA, Chelu MG, Li N. Genetics of atrial fibrillation. Curr Opin Cardiol. 2021;36(3):281-287. doi: 10.1097/HCO.0000000000000840.Kim JA, Chelu MG, Li N. Genetics of atrial fibrillation. Curr Opin Cardiol. 2021;36(3):281-287. doi: 10.1097/HCO.0000000000000840.Sheng Y, Wang YY, Chang Y, et al. Deciphering mechanisms of cardiomyocytes and non-cardiomyocyte transformation in myocardial remodeling of permanent atrial fibrillation. J Adv Res. 2024;61:101-117. doi: 10.1016/j.jare.2023.09.012.Sheng Y, Wang YY, Chang Y, et al. Deciphering mechanisms of cardiomyocytes and non-cardiomyocyte transformation in myocardial remodeling of permanent atrial fibrillation. J Adv Res. 2024;61:101-117. doi: 10.1016/j.jare.2023.09.012.Поморцев А.В., Карахалис М.Н., Матулевич С.А., и др. Пороки развития сердца плода: факторы риска и возможности ультразвукового метода при первом скрининге. Инновационная медицина Кубани. 2023;(4):51-59. https://doi.org/10.35401/2541-9897-2023-8-4-51-59Pomortsev A.V., Karakhalis M.N., Matulevich S.A., et al. Congenital Heart Diseases: Risk Factors and Ultrasound Diagnostic Potential at the First Screening. Innovative Medicine of Kuban. 2023;(4):51-59. (In Russ.) https://doi.org/10.35401/2541-9897-2023-8-4-51-59Molck MC, Simioni M, Paiva Vieira T, et al. Genomic imbalances in syndromic congenital heart disease. J Pediatr (Rio J). 2017;93(5):497-507. doi: 10.1016/j.jped.2016.11.007.Molck MC, Simioni M, Paiva Vieira T, et al. Genomic imbalances in syndromic congenital heart disease. J Pediatr (Rio J). 2017;93(5):497-507. doi: 10.1016/j.jped.2016.11.007.Xu W, Ahmad A, Dagenais S, Iyer RK, Innis JW. Chromosome 4q deletion syndrome: narrowing the cardiovascular critical region to 4q32.2-q34.3. Am J Med Genet A. 2012;158A(3):635-40. doi: 10.1002/ajmg.a.34425.Xu W, Ahmad A, Dagenais S, Iyer RK, Innis JW. Chromosome 4q deletion syndrome: narrowing the cardiovascular critical region to 4q32.2-q34.3. Am J Med Genet A. 2012;158A(3):635-40. doi: 10.1002/ajmg.a.34425.Strehle EM, Yu L, Rosenfeld JA, et al. Genotype-phenotype analysis of 4q deletion syndrome: proposal of a critical region. Am J Med Genet A. 2012;158A(9):2139-51. doi: 10.1002/ajmg.a.35502.Strehle EM, Yu L, Rosenfeld JA, et al. Genotype-phenotype analysis of 4q deletion syndrome: proposal of a critical region. Am J Med Genet A. 2012;158A(9):2139-51. doi: 10.1002/ajmg.a.35502.Liang F, Wang B, Geng J, et al. SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients. Elife. 2021;10:e67481. doi: 10.7554/eLife.67481.Liang F, Wang B, Geng J, et al. SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients. Elife. 2021;10:e67481. doi: 10.7554/eLife.67481.Бондарь И.А., Демин А.А., Гражданкина Д.В. Сахарный диабет 2 типа: взаимосвязь исходных клинико-лабораторных и эхокардиографических показателей с отдалёнными неблагоприятными сердечно-сосудистыми событиями. Сахарный диабет. 2022;25(2):136-144. https://doi.org/10.14341/DM12823Bondar I.A., Demin A.A., Grazhdankina D.V. Diabetes mellitus type 2: the relationship of baseline clinical, laboratory and echocardiographic parameters with long-term major adverse cardiovascular events. Diabetes mellitus. 2022;25(2):136-144. (In Russ.) https://doi.org/10.14341/DM12823Lu T, Chai Q, Jiao G, et al. Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients. Cardiovasc Res. 2019;115(1):145-153. doi: 10.1093/cvr/cvy137.Lu T, Chai Q, Jiao G, et al. Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients. Cardiovasc Res. 2019;115(1):145-153. doi: 10.1093/cvr/cvy137.Vujkovic M, Keaton JM, Lynch JA, et al. Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis. Nat Genet. 2020;52(7):680-691. doi: 10.1038/s41588-020-0637-y.Vujkovic M, Keaton JM, Lynch JA, et al. Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis. Nat Genet. 2020;52(7):680-691. doi: 10.1038/s41588-020-0637-y.Spracklen CN, Horikoshi M, Kim YJ, et al. Identification of type 2 diabetes loci in 433,540 East Asian individuals. Nature. 2020;582(7811):240-245. doi: 10.1038/s41586-020-2263-3.Spracklen CN, Horikoshi M, Kim YJ, et al. Identification of type 2 diabetes loci in 433,540 East Asian individuals. Nature. 2020;582(7811):240-245. doi: 10.1038/s41586-020-2263-3.Lu T, Lee HC. Coronary Large Conductance Ca2+-Activated K+ Channel Dysfunction in Diabetes Mellitus. Front Physiol. 2021;12:750618. doi: 10.3389/fphys.2021.750618.Lu T, Lee HC. Coronary Large Conductance Ca2+-Activated K+ Channel Dysfunction in Diabetes Mellitus. Front Physiol. 2021;12:750618. doi: 10.3389/fphys.2021.750618.Nystoriak MA, Nieves-Cintrón M, Nygren PJ, et al. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014;114(4):607-15. doi: 10.1161/CIRCRESAHA.114.302168.Nystoriak MA, Nieves-Cintrón M, Nygren PJ, et al. AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res. 2014;114(4):607-15. doi: 10.1161/CIRCRESAHA.114.302168.Yi F, Wang H, Chai Q, et al. Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels. J Biol Chem. 2014;289(15):10853-10864. doi: 10.1074/jbc.M113.520940Yi F, Wang H, Chai Q, et al. Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels. J Biol Chem. 2014;289(15):10853-10864. doi: 10.1074/jbc.M113.520940Sun X, Qian LL, Li Y, et al. Regulation of KCNMA1 transcription by Nrf2 in coronary arterial smooth muscle cells. J Mol Cell Cardiol. 2020;140:68-76. doi: 10.1016/j.yjmcc.2020.03.001.Sun X, Qian LL, Li Y, et al. Regulation of KCNMA1 transcription by Nrf2 in coronary arterial smooth muscle cells. J Mol Cell Cardiol. 2020;140:68-76. doi: 10.1016/j.yjmcc.2020.03.001.Турушева А.В., Котовская Ю.В., Фролова Е.В., и др. Влияние артериальной гипертензии на смертность и развитие гериатрических синдромов. Артериальная гипертензия. 2022;28(4):419-427. https://doi.org/10.18705/1607-419X-2022-28-4-419-427Turusheva A.V., Kotovskaya Yu.V., Frolova E.V., еt al. The impact of hypertension on mortality and the risk of developing geriatric syndromes. "Arterial’naya Gipertenziya" ("Arterial Hypertension"). 2022;28(4):419-427. (In Russ.) https://doi.org/10.18705/1607-419X-2022-28-4-419-427Hoffmann TJ, Ehret GB, Nandakumar P, et al. Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. Nat Genet. 2017;49(1):54-64. doi: 10.1038/ng.3715.Hoffmann TJ, Ehret GB, Nandakumar P, et al. Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. Nat Genet. 2017;49(1):54-64. doi: 10.1038/ng.3715.Кобалава Ж.Д., Конради А.О., Недогода С.В., и др. Артериальная гипертензия у взрослых. Клинические рекомендации 2024. Российский кардиологический журнал. 2024;29(9):6117. https://doi.org/10.15829/1560-4071-2024-6117. EDN: GUEWLUKobalava Zh.D., Konradi A.O., Nedogoda S.V., et al. 2024 Clinical practice guidelines for Hypertension in adults. Russian Journal of Cardiology. 2024;29(9):6117. (In Russ.) https://doi.org/10.15829/1560-4071-2024-6117. EDN: GUEWLUWang D, Uhrin P, Mocan A, Waltenberger B, et al. Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: molecular targets and pathways. Biotechnol Adv. 2018;36(6):1586-1607. doi: 10.1016/j.biotechadv.2018.04.006.Wang D, Uhrin P, Mocan A, Waltenberger B, et al. Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: molecular targets and pathways. Biotechnol Adv. 2018;36(6):1586-1607. doi: 10.1016/j.biotechadv.2018.04.006.Zhang JR, Sun HJ. MiRNAs, lncRNAs, and circular RNAs as mediators in hypertension-related vascular smooth muscle cell dysfunction. Hypertens Res. 2021;44(2):129-146. doi: 10.1038/s41440-020-00553-6.Zhang JR, Sun HJ. MiRNAs, lncRNAs, and circular RNAs as mediators in hypertension-related vascular smooth muscle cell dysfunction. Hypertens Res. 2021;44(2):129-146. doi: 10.1038/s41440-020-00553-6.Zheng F, Ye C, Ge R, et al. MiR-21-3p in extracellular vesicles from vascular fibroblasts of spontaneously hypertensive rat promotes proliferation and migration of vascular smooth muscle cells. Life Sci. 2023;330:122023. doi: 10.1016/j.lfs.2023.122023.Zheng F, Ye C, Ge R, et al. MiR-21-3p in extracellular vesicles from vascular fibroblasts of spontaneously hypertensive rat promotes proliferation and migration of vascular smooth muscle cells. Life Sci. 2023;330:122023. doi: 10.1016/j.lfs.2023.122023.Holtzclaw JD, Grimm PR, Sansom SC. Role of BK channels in hypertension and potassium secretion. Curr Opin Nephrol Hypertens. 2011;20(5):512-7. doi: 10.1097/MNH.0b013e3283488889.Holtzclaw JD, Grimm PR, Sansom SC. Role of BK channels in hypertension and potassium secretion. Curr Opin Nephrol Hypertens. 2011;20(5):512-7. doi: 10.1097/MNH.0b013e3283488889.Yang Y, Li PY, Cheng J, et al. Function of BKCa channels is reduced in human vascular smooth muscle cells from Han Chinese patients with hypertension. Hypertension. 2013;61(2):519-25. doi: 10.1161/HYPERTENSIONAHA.111.00211.Yang Y, Li PY, Cheng J, et al. Function of BKCa channels is reduced in human vascular smooth muscle cells from Han Chinese patients with hypertension. Hypertension. 2013;61(2):519-25. doi: 10.1161/HYPERTENSIONAHA.111.00211.Cho MJ, Lee MR, Park JG. Aortic aneurysms: current pathogenesis and therapeutic targets. Exp Mol Med. 2023;55(12):2519-2530. doi: 10.1038/s12276-023-01130-w.Cho MJ, Lee MR, Park JG. Aortic aneurysms: current pathogenesis and therapeutic targets. Exp Mol Med. 2023;55(12):2519-2530. doi: 10.1038/s12276-023-01130-w.Pinard A, Jones GT, Milewicz DM. Genetics of Thoracic and Abdominal Aortic Diseases. Circ Res. 2019;124(4):588-606. doi: 10.1161/CIRCRESAHA.118.312436.Pinard A, Jones GT, Milewicz DM. Genetics of Thoracic and Abdominal Aortic Diseases. Circ Res. 2019;124(4):588-606. doi: 10.1161/CIRCRESAHA.118.312436.Wang C, Qu B, Wang Z, et al. Proteomic identification of differentially expressed proteins in vascular wall of patients with ruptured intracranial aneurysms. Atherosclerosis. 2015;238(2):201-6. doi: 10.1016/j.atherosclerosis.2014.11.027.Wang C, Qu B, Wang Z, et al. Proteomic identification of differentially expressed proteins in vascular wall of patients with ruptured intracranial aneurysms. Atherosclerosis. 2015;238(2):201-6. doi: 10.1016/j.atherosclerosis.2014.11.027.

The authors declare that there are no conflicts of interest present.