kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2025-14-6S-257-272kpccz-1740Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОР. Трансплантология и искусственные органыНЕКОТОРЫЕ ВИДОСПЕЦИФИЧЕСКИЕ ОСОБЕННОСТИ НАИБОЛЕЕ ПОПУЛЯРНЫХ ЛАБОРАТОРНЫХ ЖИВОТНЫХ МОДЕЛЕЙ, ВЛИЯЮЩИЕ НА РЕЗУЛЬТАТИВНОСТЬ ПРЕКЛИНИЧЕСКИХ ИСПЫТАНИЙ БИОДЕГРАДИРУЕМЫХ СОСУДИСТЫХ ПРОТЕЗОВ МАЛОГО ДИАМЕТРА (ОБЗОР ЛИТЕРАТУРЫ)SPECIES-SPECIFIC CHARACTERISTICS OF WIDELY USED LABORATORY ANIMAL MODELS AND THEIR IMPACT ON THE EFFICACY OF PRECLINICAL STUDIES FOR SMALL-DIAMETER BIODEGRADABLE VASCULAR PROSTHESES (A REVIEW)https://orcid.org/0000-0002-8874-0788АнтоноваЛариса ВалерьевнаAntonovaLarisa V.

доктор медицинских наук ведущий научный сотрудник лаборатории клеточных технологий отдела экспериментальной медицины федерального государственного бюджетного научного учреждения «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Российская Федерация

PhD, Leading Researcher, Laboratory of Cell Technologies, Department of Experimental Medicine, Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo, Russian Federation

antonova.la@mail.ruhttps://orcid.org/0000-0002-9430-937XСенокосоваЕвгения АндреевнаSenokosovaEvgenia A.

кандидат биологических наук заведующий лабораторией клеточных технологий отдела экспериментальной медицины федерального государственного бюджетного научного учреждения «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Российская Федерация

PhD, Head of the Laboratory of Cell Technologies, Department of Experimental Medicine, Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo, Russian Federation

sergeewa.ew@yandex.ruhttps://orcid.org/0000-0002-8826-9244ХановаМарьям ЮрисовнаKhanovaMaryam Yu.

кандидат биологических наук научный сотрудник лаборатории клеточных технологий отдела экспериментальной медицины федерального государственного бюджетного научного учреждения «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Российская Федерация

PhD, Researcher, Laboratory of Cell Technologies, Department of Experimental Medicine, Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo, Russian Federation

khanovam@gmail.comhttps://orcid.org/0000-0002-8846-5077МироновАндрей ВладимировичMironovAndrey V.

кандидат медицинских наук младший научный сотрудник лаборатории клеточных технологий федерального государственного бюджетного научного учреждения «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Российская Федерация

PhD, Junior Researcher at the Laboratory of Cell Technologies of the Federal State Budgetary Scientific Institution "Scientific Research Institute of Complex Problems of Cardiovascular Diseases", Kemerovo, Russian Federation

miroav@kemcardio.ruФедеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияFederal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”Russian Federation202518032026146S257272Copyright © Антонова Л.В., Сенокосова Е.А., Ханова М.Ю., Миронов А.В., 20252025Антонова Л.В., Сенокосова Е.А., Ханова М.Ю., Миронов А.В.Antonova L.V., Senokosova E.A., Khanova M.Y., Mironov A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/1740Основные положения

Основные положения

На рынке изделий для нужд сердечно-сосудистой хирургии отсутствуют эффективные сосудистые протезы диаметром менее 4 мм. Биодеградируемые протезы с пролонгированной резорбцией и регенеративным потенциалом рассматриваются как альтернатива. Полнота оценки рисков таких протезов в преклинических испытаниях зависит от выбранной животной модели.

 

 

Резюме

Резюме

На рынке изделий для нужд сердечно-сосудистой хирургии до сих пор не существует эффективного сосудистого протеза диаметром менее 4 мм. Альтернативой может стать биодеградируемый сосудистый протез, обладающий пролонгированной резорбцией и способностью к регенерации. Полнота определения рисков несостоятельности биодеградируемых протезов сосудов малого диаметра, подвергаемых преклиническим испытаниям, напрямую зависит от животной модели, выбранной для проведения подобных испытаний. В данном литературном обзоре представлены основные тенденции последних лет по выбору животных моделей для проведения преклинических испытаний биодеградируемых сосудистых протезов малого диаметра и оценены результативность испытаний в разрезе видоспецифических особенностей наиболее популярных мелких и крупных животных моделей.

Highlights

Highlights

Effective vascular grafts with diameters less than 4 mm remain unavailable on the market for cardiovascular surgery applications. Biodegradable grafts featuring prolonged resorption and regenerative potential are considered a viable alternative. The comprehensiveness of risk assessment for such grafts in preclinical trials is contingent upon the selected animal model.

 

 

Abstract

Abstract

There is still no effective vascular prosthesis with a diameter of less than 4 mm on the market of products for the needs of cardiovascular surgery. A biodegradable vascular prosthesis with prolonged resorption and regenerative capacity may be an alternative. The completeness of determining the risks of failure of biodegradable prostheses of small-diameter vessels subjected to preclinical tests directly depends on the animal model chosen for such tests. This literature review presents the main trends in recent years in the selection of animal models for preclinical testing of biodegradable vascular prostheses of small diameter and evaluates the effectiveness of tests in the context of species-specific features of the most popular small and large animal models.

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The authors declare that there are no conflicts of interest present.