kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2025-14-6-249-258kpccz-1742Research ArticleОНЛАЙН. АНАЛИТИЧЕСКИЙ ОБЗОР. Патологическая физиологияЭНДОКАРДИТ, ОБУСЛОВЛЕННЫЙ МИКРООРГАНИЗМАМИ ГРУППЫ HACEK (ОБЗОР ЛИТЕРАТУРЫ)ENDOCARDITIS CAUSED BY HACEK GROUP MICROORGANISMShttps://orcid.org/0000-0001-9825-1139СвищеваМария ВладимировнаSvishchevaMaria V.

кандидат медицинских наук доцент кафедры медико-биологических дисциплин автономной некоммерческой организации высшего образования «Московский университет «Синергия», Москва, Российская Федерация

PhD, Associate Professor, Moscow University for Industry and Finance “Synergy”, Moscow, Russian Federation

mascha.svisheva@yandex.ruhttps://orcid.org/0009-0002-5327-7794СидняевВиталий АлександровичSidnyaevVitaly A.

клинический психолог, студент медицинского факультета автономной некоммерческой организации высшего образования «Московский университет «Синергия», Москва, Российская Федерация

Clinical Psychologist, Medical Student, Moscow University for Industry and Finance “Synergy”, Moscow, Russian Federation

vitaliysidnyaev@mail.ruhttps://orcid.org/0000-0001-8243-5902КузнецоваМария АлександровнаKuznetsovaMaria A.

кандидат медицинских наук доцент кафедры медико-биологических дисциплин автономной некоммерческой организации высшего образования «Московский университет «Синергия», Москва, Российская Федерация

PhD, Associate Professor, Moscow University for Industry and Finance “Synergy”, Moscow, Russian Federation

Aelaya@hotmail.comhttps://orcid.org/0009-0009-8624-5896ПечаткинМихаил МихайловичPechatkinMikhail M.

студент медицинского факультета автономной некоммерческой организации высшего образования «Московский университет «Синергия», Москва, Российская Федерация

Medical Student, Moscow University for Industry and Finance “Synergy”, Moscow, Russian Federation

Mihail-pechkin@mail.ruhttps://orcid.org/0009-0004-1303-627XВардовКонстантин ВладимировичVardovKonstantin V.

студент медицинского факультета автономной некоммерческой организации высшего образования «Московский университет «Синергия», Москва, Российская Федерация

Medical Student, Moscow University for Industry and Finance “Synergy”, Moscow, Russian Federation

vardovkonstantin@gmail.comАвтономная некоммерческая организация высшего образования «Московский университет «Синергия»РоссияMoscow University for Industry and Finance “Synergy”Russian Federation202530122025146249258Copyright © Свищева М.В., Сидняев В.А., Кузнецова М.А., Печаткин М.М., Вардов К.В., 20252025Свищева М.В., Сидняев В.А., Кузнецова М.А., Печаткин М.М., Вардов К.В.Svishcheva M.V., Sidnyaev V.A., Kuznetsova M.A., Pechatkin M.M., Vardov K.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/1742Основные положения

Основные положения

Проведен систематический обзор современных научных данных по этиологии, эпидемиологии, патогенезу, особенностям лабораторной диагностики и этиотропного лечения НАСЕК-эндокардита. Для анализа исследований использованы такие информационные платформы и сервисы академического поиска, как PubMed, Web of Science, Google Scholar, eLIBRARY.RU, «КиберЛенинка». Поиск осуществлен по ключевым словам, после первичного анализа отобрано 45 статей. Необходимо продолжать изучение эпидемиологических, клинических, иммунопатологических и микробиологических аспектов HACEK-ИЭ.

 

 

Резюме

Резюме

Инфекционный эндокардит, вызванный микроорганизмами группы HACEK (Haemophilus spp., Aggregatibacter spp., Cardiobacterium spp., Eikenella corrodens и Kingella spp.), представляет собой редкую, но жизнеугрожающую патологию, требующую своевременной диагностики и корректного лечения. В обзоре проанализированы современные данные об эпидемиологии, микробиологических особенностях, диагностике, лечении и прогнозе HACEK-эндокардита. Освещены различия в распространенности заболевания, факторы риска и предикторы его развития у различных категорий пациентов. Охарактеризованы клинические проявления HACEK-эндокардита. Рассмотрены возможности лабораторной диагностики HACEK-эндокардита с акцентом на культуральные и молекулярно-генетические методы. Проанализированы современные подходы к антибактериальной терапии и хирургическому лечению заболевания с учетом нарастающей антибиотикорезистентности возбудителей. Представлены данные о госпитальной летальности пациентов с HACEK-эндокардитом. Определены нерешенные проблемы и перспективные направления дальнейших исследований данной патологии.

Highlights

Highlights

A systematic review of modern scientific data on the etiology, epidemiology, pathogenesis, features of laboratory diagnostics and etiotropic treatment of endocarditis by HACEK was conducted. To analyze the research, we used information platforms and scholarly search services such as PubMed, Web of Science, Google Scholar, eLIBRARY.RU, and CyberLeninka. The search was carried out by keywords; after the initial analysis, 45 articles were selected. Further study of the epidemiological, clinical, immunopathological and microbiological aspects of Infective endocarditis by HACEK is necessary.

 

 

Abstract

Abstract

Infective endocarditis caused by HACEK group microorganisms (Haemophilus spp., Aggregatibacter spp., Cardiobacterium spp., Eikenella corrodens, and Kingella spp.) is a rare but potentially life-threatening condition that requires timely diagnosis and adequate treatment. This review analyzes current data on the epidemiology, microbiological features, diagnosis, treatment, and prognosis of HACEK endocarditis. Regional differences in the prevalence of the disease, risk factors, and predictors of its development in various patient categories are highlighted. The clinical manifestations of HACEK endocarditis are characterized in detail. The possibilities of laboratory diagnosis of HACEK endocarditis with an emphasis on culture and molecular genetic methods are considered. Modern approaches to antibacterial therapy and surgical treatment of the disease, taking into account the increasing antibiotic resistance of pathogens, are analyzed. Data on hospital mortality of patients with HACEK endocarditis are presented. Unresolved problems and promising directions for further research of this pathology are identified.

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The authors declare that there are no conflicts of interest present.