kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2025-14-6-259-277kpccz-1784Research ArticleОНЛАЙН. ИСТОРИЧЕСКИЙ ОЧЕРК. Кардиология. Патологическая физиологияONLINE. HISTORICAL REVIEW. Cardiology. Pathological physiologyПАТОФИЗИОЛОГИЯ ИНФАРКТА МИОКАРДА: ИСТОРИЧЕСКИЕ ОЧЕРКИ И НОВЫЕ ГОРИЗОНТЫPATHOPHYSIOLOGY OF MYOCARDIAL INFARCTION: HISTORICAL ESSAYS AND NEW HORIZONShttps://orcid.org/0000-0002-8493-0058ПетроваМарина МихайловнаPetrovaMarina M.

доктор медицинских наук, профессор заведующая кафедрой поликлинической терапии и семейной медицины с курсом ПО федерального государственного бюджетного образовательного учреждения высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации, Красноярск, Российская Федерация

PhD, Professor, Head of the Department of Outpatient Treatment and Family Medicine, Federal State Budgetary Educational Institution of Higher Education “Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnoyarsk, Russian Federation

stk99@yandex.ruhttps://orcid.org/0000-0002-0091-5265ШимохинаНаталья ЮрьевнаShimokhinaNatalia Yu.

доктор медицинских наук профессор кафедры поликлинической терапии и семейной медицины с курсом ПО федерального государственного бюджетного образовательного учреждения высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации, Красноярск, Российская Федерация

PhD, Associate professor of Department of Polyclinic Therapy and Family medicine with Residency Course, Federal State Budgetary Educational Institution of Higher Education “Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnoyarsk, Russian Federation

https://orcid.org/0000-0003-1575-633XЕвсюковАлександр АлександровичEvsyukovAlexander A.

кандидат медицинских наук доцент кафедры поликлинической терапии и семейной медицины с курсом ПО федерального государственного бюджетного образовательного учреждения высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации, Красноярск, Российская Федерация

PhD, Associate professor of Department of Polyclinic Therapy and Family medicine with Residency Course, Federal State Budgetary Educational Institution of Higher Education “Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnoyarsk, Russian Federation

https://orcid.org/0000-0002-2840-837XШнайдерНаталья АлексеевнаSchneiderNatalia A.

доктор медицинских наук, профессор ведущий научный сотрудник центра коллективного пользования «Молекулярные и клеточные технологии» федерального государственного бюджетного образовательного учреждения высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации, Красноярск, Российская Федерация

PhD, MD, Professor, Leading Researcher, Molecular and Cellular Technologies Shared Use Center, Federal State Budgetary Educational Institution of Higher Education “Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnoyarsk, Russian Federation

https://orcid.org/0000-0002-0794-2530КаскаеваДарья СергеевнаKaskaevaDaria S.

кандидат медицинских наук доцент кафедры поликлинической терапии и семейной медицины с курсом ПО федерального государственного бюджетного образовательного учреждения высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации, Красноярск, Российская Федерация

PhD, Associate Professor of the Department of Polyclinic Therapy and Family Medicine with a Postgraduate Course, Federal State Budgetary Educational Institution of Higher Education “Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnoyarsk, Russian Federation

https://orcid.org/0009-0002-3716-5346КудратовСанджархон ХакимджоновичKudratovSanjarkhon H.

студент 6-го курса лечебного факультета федерального государственного бюджетного образовательного учреждения высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации, Красноярск, Российская Федерация

the 6th-year undergraduate of General Medicine, Federal State Budgetary Educational Institution of Higher Education “Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnoyarsk, Russian Federation

s.kudratov1902@gmail.comФедеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education “Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University” of the Ministry of Healthcare of the Russian FederationRussian Federation202530122025146259277Copyright © Петрова М.М., Шимохина Н.Ю., Евсюков А.А., Шнайдер Н.А., Каскаева Д.С., Кудратов С.Х., 20252025Петрова М.М., Шимохина Н.Ю., Евсюков А.А., Шнайдер Н.А., Каскаева Д.С., Кудратов С.Х.Petrova M.M., Shimokhina N.Y., Evsyukov A.A., Schneider N.A., Kaskaeva D.S., Kudratov S.H.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/1784Основные положения

Основные положения

В аналитическом обзоре освещены основные патофизиологические механизмы развития инфаркта миокарда, включая сложные молекулярные процессы, приводящие к ишемии и некрозу сердечной мышцы. Исторически представления об этом состоянии прошли длительный путь – от первых описаний до современных методов диагностики и лечения, что значительно улучшило прогноз у пациентов с инфарктом миокарда.

 

 

Резюме

Резюме

Понимание исторических аспектов и патофизиологии инфаркта миокарда имеет важное значение как для медицинских специалистов, так и пациентов. Знание механизмов развития инфаркта миокарда позволяет врачам более точно оценивать состояние пациента и выбирать оптимальные методы лечения, включая медикаментозную терапию и интервенционные процедуры. Проведен анализ научных статей, изданных в течение последнего десятилетия, с применением поисковых систем PubMed и eLibrary по ключевым словам: «атеросклероз», «история инфаркта миокарда», «патофизиология инфаркта миокарда», «ишемическая болезнь сердца», «патогенез атеротромбоза», «эндотелий», «воспаление». При отборе предпочтение отдавалось систематическим обзорам и метаанализам как источникам с наивысшим уровнем доказательности, а также рандомизированным контролируемым исследованиям, крупным когортным исследованиям и авторитетным клиническим рекомендациям.

Highlights

Highlights

In the analytical review, the main pathophysiological mechanisms of myocardial infarction development are presented, including complex molecular processes that lead to ischemia and necrosis of the heart muscle. Historically, understanding of this condition has come a long way from its first descriptions to modern diagnostic and treatment methods, which have significantly improved the prognosis for patients with MI. Understanding the history and pathophysiology of myocardial infarction is key to medical practice, research, and patient education. This knowledge contributes to improved diagnosis, treatment, and prevention, which ultimately leads to improved quality of life for patients and a reduced burden of cardiovascular disease at the societal level.

 

 

Abstract

Abstract

Understanding the historical aspects and pathophysiology of myocardial infarction is important for both medical professionals and patients. Knowledge of the mechanisms of myocardial infarction development allows physicians to more accurately assess the patient’s condition and choose optimal treatment methods, including drug therapy and interventional procedures. An analysis of scientific literature and articles published over the past decade was conducted using the resources of the PubMed and eLibrary search engines using the following keywords: atherosclerosis, history of myocardial infarction, pathophysiology of myocardial infarction, ischemic heart disease, pathogenesis of atherothrombosis, endothelium, inflammation. In the selection, preference was given to systematic reviews and meta-analyses as sources with the highest level of evidence, as well as randomized controlled trials (RCTs), large cohort studies and authoritative clinical guidelines.

История инфаркта миокардаТромбоз коронарных артерийПатофизиология инфаркта миокардаАтеросклерозОстрый инфаркт миокардаОстрый коронарный синдромHistory of myocardial infarctionCoronary artery thrombosisPathophysiology of myocardial infarctionAtherosclerosisAcute myocardial infarctionAcute coronary syndromeРабота выполнена в рамках государственного задания ФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В. Ф. Войно-Ясенецкого» МЗ России (2023–2025) «Разработка персонализированного алгоритма диагностики сосудистой умеренной когнитивной дисфункции на фоне перенесенного острого инфаркта миокарда на основе новых генетических и биохимических биомаркеров», № 123022800057-6.ReferencesСавенко С.А., Полонецкий Л.З., Денисевич Т.Л. Эволюция патогенетического лечения инфаркта миокарда. Кардиология в Беларуси. 2018;10(4):545-560.References:Malach M, Imperato PJ. Acute myocardial infarction and acute coronary syndrome: then and now (1950-2005). 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The authors declare that there are no conflicts of interest present.