kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2016-4-87-95kpccz-241Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОРANALYTICAL REVIEWИННОВАЦИЯ В МЕДИКАМЕНТОЗНОМ ЛЕЧЕНИИ ПАЦИЕНТОВ С ЛЕГОЧНОЙ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ И НЕОПЕРАБЕЛЬНОЙ, ПЕРСИСТИРУЮЩЕЙ/ РЕЗИДУАЛЬНОЙ ФОРМАМИ ХРОНИЧЕСКОЙ ТРОМБОЭМБОЛИЧЕСКОЙ ЛЕГОЧНОЙ ГИПЕРТЕНЗИИ: СТИМУЛЯТОР РАСТВОРИМОЙ ГУАНИЛАТЦИКЛАЗЫ – РИОЦИГУАТINNOVATION IN THE MEDICAL TREATMENT Of PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION AND INOPERABLE, PERSISTENT/RECURRENT CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION: SOLUBLE GUANILATE CYCLASE STIMULATOR – RIOCIGUATТАРАНИ. Н.TARANI. N.

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zaviirina@mail.ruМАРТЫНЮКТ. В.MARTYNUKT. V.НАКОНЕЧНИКОВС. Н.NAKONECHNIKOVS. N.ЧАЗОВАИ. Е.CHAZOVAI. E.Федеральное государственное бюджетное учреждение «Российский кардиологический научно-производственный комплекс» Минздрава РФ; Научно-исследовательский институт кардиологии им. А. Л. Мясникова, лаборатория легочной гипертензии, отдел гипертонии. Москва, РоссияРоссияFederal State Budgetary Institution Russian Cardiology Research and Production Complex, Scientific research institute of clinical cardiology of A. L. Myasnikov; Laboratory of a pulmonary hypertension, Department of a hypertension, Moscow, RussiaRussian Federation201602122016048795Copyright © ТАРАН И.Н., МАРТЫНЮК Т.В., НАКОНЕЧНИКОВ С.Н., ЧАЗОВА И.Е., 20162016ТАРАН И.Н., МАРТЫНЮК Т.В., НАКОНЕЧНИКОВ С.Н., ЧАЗОВА И.Е.TARAN I.N., MARTYNUK T.V., NAKONECHNIKOV S.N., CHAZOVA I.E.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/241

Легочная артериальная гипертензия (ЛАГ) и хроническая тромбоэмболическая легочная гипертензия (ХТЭЛГ ) являются заболеваниями, чаще всего диагностируемыми на поздней стадии, с функциональным классом (ФК) легочной гипертензии III или IV по классификации Всемирной организации здравоохранения (ВОЗ), и приводящими к тяжелой правожелудочковой недостаточности с последующим летальным исходом. Cовременные исследования направлены на изучение фундаментальных терапевтических мишеней и на создание новых лекарственных препаратов, воздействующих на ранее установленные мишени. Риоцигуат – первый представитель нового класса лекарственных препаратов-стимуляторов растворимой гуанилатциклазы (рГЦ ). В обзоре проводится анализ основных исследований, в которых оценивалась эффективность/безопасность риоцигуата у пациентов с Л АГ и неоперабельной, персистирующей/резидульной формами ХТЭЛГ.

Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are diseases, diagnosed at a late stage with functional class III or IV according to World health organization (WHO). PAH and CTEPH leads to severe right heart failureand ultimately, death. The modern researches aim at exploring the potential therapeutic targets, as at developing new drugs that can affect the previously set target. Riociguat is the first in a new class of soluble guanylatecyclase stimulators. The analysis of main researches, which reflect the evidence of riociguat efficiacy and safety in patients with PAH and inoperable, persistent/recurrent CTEPH, is presented in this rewiew.

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The authors declare that there are no conflicts of interest present.