kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2017-1-92-101kpccz-268Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEW ARTICLEРОЛЬ МУТАГЕНЕЗА В РАЗВИТИИ АТЕРОСКЛЕРОЗАTHE ROLE OF MUTAGENESIS IN ATHEROSCLEROSISКУТИХИНА. Г.KUTIKHINA. G.

650002, г. Кемерово, Сосновый бульвар, д. 6 Тел. +79609077067

6, Sosnoviy blvd., Kemerovo, 650002, Russian Federation Tel. +79609077067

antonkutikhin@gmail.comСИНИЦКИЙМ. Ю.SINITSKYM. Y.

Кемерово, Россия

Kemerovo, Russia

ПОНАСЕНКОА. В.PONASENKOA. V.

Кемерово, Россия

Kemerovo, Russia

Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular DiseasesRussian Federation2017080620170192101Copyright © КУТИХИН А.Г., СИНИЦКИЙ М.Ю., ПОНАСЕНКО А.В., 20172017КУТИХИН А.Г., СИНИЦКИЙ М.Ю., ПОНАСЕНКО А.В.KUTIKHIN A.G., SINITSKY M.Y., PONASENKO A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/268

Атеросклероз, развивающийся в результате вызванного дисфункцией эндотелия внутрисосудистого воспаления и клинически проявляющийся ишемической болезнью сердца, острым нарушением мозгового кровообращения и заболеваниями периферических артерий, продолжает оставаться абсолютно ведущей причиной смертности. За последние четыре десятилетия было накоплено достаточно доказательств роли эндогенного и экзогенного мутагенеза в развитии атеросклероза, что позволяет рассматривать это заболевание как в некоторой степени неопластический процесс. В данном обзоре кратко освещены классические работы в этом направлении и описаны основные аргументы, подтверждающие связь мутагенеза и атеросклероза. К наиболее весомым аргументам можно отнести стимулирование развития атеросклероза активными формами кислорода, нарушение регуляции длины теломер при атеросклерозе и ускоренное развитие атеросклероза у пациентов с наследственными синдромами нарушения репарации ДНК, а также у больных, перенесших химиотерапию и лучевую терапию. Кроме того, проанализированы возможные терапевтические применения знаний о роли мутагенеза в развитии атеросклероза; в частности, подчеркнут антимутагенный эффект статинов и ингибиторов ангиотензинпревращающего фермента, что может быть дополнительной причиной их эффективности в терапии клинических осложнений атеросклероза.

Atherosclerosis causing by endothelial dysfunction following vascular inflammation can lead to thrombosis and artery occlusion, resulting in myocardial infarction, ischemic stroke, or peripheral artery disease. There is a convincing evidence on the impact of endogenous and exogenous mutagenesis in atherosclerosis; therefore, it can be partially considered as a neoplastic process. Here we describe the seminal papers in the field and provide the arguments on the association of mutagenesis with atherosclerosis. In particular, we underline the importance of oxidative stress, telomere dysfunction, DNA damage syndromes, and cytotoxic chemotherapy/radiotherapy. We also consider the therapeutical applications of antimutagens, particularly statins and angiotensin-converting enzyme inhibitors.

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The authors declare that there are no conflicts of interest present.