References

kpccz

Комплексные проблемы сердечно-сосудистых заболеваний

Complex Issues of Cardiovascular Diseases

2306-12782587-9537

Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”

10.17802/2306-1278-2017-1-122-130

kpccz-271

Research Article

ОБЗОР ЛИТЕРАТУРЫ

REVIEW ARTICLE

ОСНОВНЫЕ НАПРАВЛЕНИЯ МОДИФИКАЦИИ ПОВЕРХНОСТИ МЕТАЛЛИЧЕСКИХ ЭНДОВАСКУЛЯРНЫХ СТЕНТОВ В РЕШЕНИИ ПРОБЛЕМЫ РЕСТЕНОЗОВ (ОБЗОР 1 ЧАСТЬ

SURFACE MODIFICATION OF BARE-METAL STENTS FOR PREVENTING RESTENOSIS (PART 1)

ЛОТКОВ

А. И.

LOTKOV

A. I.

Томск, Россия

Tomsk, Russia

МАТВЕЕВА

В. Г.

ANTONOVA

L. V.

6, Sosnoviy blvd., Kemerovo, 650002, Russian Federation Tel. +7(3842)644238

matvvg@kemcardio.ru

АНТОНОВА

Л. В.

KASHIN

O. A.

Кемерово, Россия

Tomsk, Russia

КАШИН

О. А.

MATVEEVA

V. G.

Томск, Россия

Kemerovo, Russia

КУДРЯШОВ

А. Н.

KUDRYASHOV

A. N.

Новосибирск, Россия

Novosibirsk, Russia

Федеральное государственное бюджетное учреждение науки Институт физики прочности и материаловедения Сибирского отделения Российской академии наук Федеральное государственное автономное образовательное учреждение высшего образования «Национальный исследовательский Томский государственный университет»РоссияInstitute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences Tomsk State UniversityRussian Federation

Федеральное государственное бюджетное научное учреждение «Научно- исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular DiseasesRussian Federation

Федеральное государственное бюджетное научное учреждение «Научно- исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияInstitute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of SciencesRussian Federation

Федеральное государственное бюджетное учреждение науки Институт физики прочности и материаловедения Сибирского отделения Российской академии наукРоссияFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular DiseasesRussian Federation

ООО «Ангиолайн»РоссияLLC «Angiolayn»Russian Federation

2017

08062017

01122130

2017

ЛОТКОВ А.И., МАТВЕЕВА В.Г., АНТОНОВА Л.В., КАШИН О.А., КУДРЯШОВ А.Н.

LOTKOV A.I., ANTONOVA L.V., KASHIN O.A., MATVEEVA V.G., KUDRYASHOV A.N.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nii-kpssz.com/jour/article/view/271

Рестенозы металлических стентов, возникающие после имплантации, остаются нерешенной проблемой и существенно ограничивают их терапевтическую эффективность. В обзоре освещены наиболее перспективные с точки зрения физиологии и клеточной биологии варианты модификации металлических поверхностей, представлены преимущества и недостатки каждого из методов. В первую часть обзора включены направления, касающиеся разработки стентов с антитромботическим и антипролиферативным покрытием, так же представлены наиболее значимые и интересные исследования, направленные на формирование на поверхности стентов эндотелиального слоя in vitro.

The therapeutic e[cacy of bare-metal stents is signiVcantly limited due to frequent restenosis. Here we review the approaches for surface modiVcation to prevent restenosis, presented the advantages and disadvantages of each method. In the Vrst part of the review, we consider antithrombotic and antiproliferative stents coating. The review presents the most signiVcant and interesting research aimed forming endothelial layer on the stents surface in vitro.

металлические стентырестенозмодификация поверхностиэндотелизация

bare-metal stentsrestenosissurface modiVcationendothelialization

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The authors declare that there are no conflicts of interest present.