kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2017-6-3-131-142kpccz-314Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОРANALYTICAL REVIEWОСНОВНЫЕ НАПРАВЛЕНИЯ МОДИФИКАЦИИ ПОВЕРХНОСТИ МЕТАЛЛИЧЕСКИХ ЭНДОВАСКУЛЯРНЫХ СТЕНТОВ В РЕШЕНИИ ПРОБЛЕМЫ РЕСТЕНОЗОВ (ОБЗОР, 2 ЧАСТЬ)SURFACE MODIFICATION OF BARE-METAL STENTS FOR PREVENTING RESTENOSIS (PART 2)ЛотковА. И.LotkovA. I.

Томск

Tomsk

МатвееваВ. Г.MatveevaV. G.

Кемерово

Kemerovo

АнтоноваЛ. В.AntonovaL. V.

650002, г. Кемерово, Сосновый бульвар, д. 6

6, Sosnoviy blvd., Kemerovo, 650002

antolv@kemcardio.ruКашинО. А.KashinO. A.

Томск

Tomsk

КудряшовА. Н.KudryashovA. N.

Новосибирск

Novosibirsk

Институт физики прочности и материаловедения СО РАН; Томский государственный университетРоссияInstitute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of Sciences; National Research Tomsk State UniversityRussian FederationФедеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”Russian FederationИнститут физики прочности и материаловедения СО РАНРоссияInstitute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of SciencesRussian FederationООО «Ангиолайн»РоссияLLC «Angiolayn»Russian Federation20171909201703131142Copyright © Лотков А.И., Матвеева В.Г., Антонова Л.В., Кашин О.А., Кудряшов А.Н., 20172017Лотков А.И., Матвеева В.Г., Антонова Л.В., Кашин О.А., Кудряшов А.Н.Lotkov A.I., Matveeva V.G., Antonova L.V., Kashin O.A., Kudryashov A.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/314

Вторая часть обзора посвящена вариантам модификации металлических стентов для ускорения эндотелизации in situ. Представлены разработки. направленные на захват эндотелиальных прогениторных клеток из кровотока с помощью специфических антител. Описаны возможности улучшения адгезии и интеграции эндотелиальных клеток на поверхности за счет формирования сайтов клеточного распознавания и имитация структур внеклеточного матрикса. Проанализированы различные способы физической и химической модификации, способствующие созданию условий для скорейшего формирования функционально состоятельного эндотелиального слоя на искусственных поверхностях. Определен круг проблем и ограничений в использовании каждого из методов.

Here we review the modifications of the metal stents to enhance in situ endothelialization, particularly antibody-mediated adhesion of endothelial progenitor cells. We focus on the strategies employing cell adhesion molecules and extracellular matrix proteins. We also encompass other physical and chemical approaches for surface biofunctionalization with their advantages and shortcomings.

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The authors declare that there are no conflicts of interest present.