kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2017-6-3-155-165kpccz-317Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОРANALYTICAL REVIEWГЕНЕТИЧЕСКИЙ ПРОФИЛЬ И СЕКРЕТОМ АДИПОЦИТОВ ВИСЦЕРАЛЬНОЙ И ПОДКОЖНОЙ ЖИРОВОЙ ТКАНИ У ПАЦИЕНТОВ С СЕРДЕЧНО-СОСУДИСТЫМИ ЗАБОЛЕВАНИЯМИGENETIC PROFILE AND SECRETOME OF ADIPOCYTES FROM VISCERAL AND SUBCUTANEOUS ADIPOSE TISSUE IN PATIENTS WITH CARDIOVASCULAR DISEASESСиницкийМ. Ю.SinitskiyM. Y.

Кемерово

Kemerovo

ПонасенкоА. В.PonasenkoA. V.

650002, г. Кемерово, Сосновый бульвар, д. 6

6 Sosnoviy blvd., Kemerovo, 650002

ponaav@kemcardio.ruГруздеваО. В.GruzdevaO. V.

Кемерово

Kemerovo

Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»; Федеральный исследовательский центр угля и углехимии СО РАНРоссияFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”; Federal Research Center of Coal and Coal Chemistry of SB RASRussian FederationФедеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»РоссияFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”Russian FederationФедеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»; Федеральное государственное бюджетное образовательное учреждение высшего образования «Кемеровский государственный медицинский университет» Минздрава РоссииРоссияFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”; Federal State Budgetary Educational Institution Higher Education Kemerovo State Medical UniversityRussian Federation20171909201703155165Copyright © Синицкий М.Ю., Понасенко А.В., Груздева О.В., 20172017Синицкий М.Ю., Понасенко А.В., Груздева О.В.Sinitskiy M.Y., Ponasenko A.V., Gruzdeva O.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/317

Жировая ткань представляет особый интерес в контексте ее ключевой роли в патогенезе сердечно-сосудистых заболеваний, дисфункции эндотелия и миокарда, гипертонии, атеросклероза и ряда других патологических состояний. На настоящий момент накоплено достаточное количество сведений о секреторной функции адипоцитов, что ведет к признанию роли жировой ткани в регуляции функционирования сердечно-сосудистой системы. Изучения молекулярно-генетических основ функционирования жировой ткани может помочь более глубокому пониманию этиопатогенетических механизмов сердечно-сосудистых заболеваний и разработать эффективную стратегию их профилактики и контроля. В данном обзоре проанализирована информация об особенностях профиля адипокинов и цитокинов, секретируемых различными типами жировой ткани (подкожная, эпикардиальная, периваскулярная), а также об изменении экспрессии ряда ключевых генов в адипоцитах, полученных из различных жировых депо, у пациентов с сердечно-сосудистыми заболеваниями.

Adipose tissue is of interest in the context of its role in pathogenesis of cardiovascular diseases, endothelium and myocardium dysfunction, hypertension, atherosclerosis and a number of other pathological conditions. The accumulation of knowledge about secretory functions of adipocytes is leading to recognition of the role of adipose tissue in regulation of cardiovascular system functioning. Studies of molecular-genetic basis of the functioning of adipose tissue can help to understand etiopathogenetic mechanisms of cardiovascular diseases and develop an effective strategy for their prevention and control. In this review, the information about adipokines and cytokines secreted by various types of adipose tissue (subcutaneous, epicardial, perivascular), as well as changes in the expression of key genes in adipocytes obtained from various fat depots in patients with cardiovascular diseases was analyzed.

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The authors declare that there are no conflicts of interest present.