<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kpccz</journal-id><journal-title-group><journal-title xml:lang="ru">Комплексные проблемы сердечно-сосудистых заболеваний</journal-title><trans-title-group xml:lang="en"><trans-title>Complex Issues of Cardiovascular Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2306-1278</issn><issn pub-type="epub">2587-9537</issn><publisher><publisher-name>Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17802/2306-1278-2018-7-4S-66-74</article-id><article-id custom-type="elpub" pub-id-type="custom">kpccz-508</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АНАЛИТИЧЕСКИЙ ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANALYTICAL REVIEW</subject></subj-group></article-categories><title-group><article-title>Перспективы физической преабилитации в профилактике послеоперационной когнитивной дисфункции у пациентов при коронарном шунтировании</article-title><trans-title-group xml:lang="en"><trans-title>Prospects of physical prehabilitation for prevention of postoperative cognitive dysfunction in patients undergoing coronary artery bypass grafting</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трубникова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Trubnikova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трубникова Ольга Александровна - доктор медицинских наук, заведующая лабораторией нейрососудистой патологии отдела мультифокального атеросклероза.</p><p>650002, Кемерово, Сосновый бульвар 6, тел. +7 (3842) 64-31-53</p></bio><bio xml:lang="en"><p>Trubnikova Olga A. - PhD, Head of the Laboratory of Neurovascular Pathology, Department of Multivessel and Polyvascular Diseases.</p><p>650002, Kemerovo, 6, Sosnovy Blvd., tel. +7 (3842) 64-31-53</p></bio><email xlink:type="simple">olgalet17@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моськин</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Moskin</surname><given-names>E. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Моськин Евгений Геннадьевич - очный аспирант.</p><p>Сосновый бульвар, 6, Кемерово, 650002</p></bio><bio xml:lang="en"><p>Moskin Eugene G. - PhD student.</p><p>6, Sosnovy Blvd., Kemerovo, 650002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гарганеева</surname><given-names>Н. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Garganeeva</surname><given-names>N. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гарганеева Наталья Петровна - доктор медицинских наук, профессор кафедры общей врачебной практики и поликлинической терапии.</p><p>Московский тракт, 2, Томск, 634050</p></bio><bio xml:lang="en"><p>Garganeeva Natalya P. - PhD, Professor at the Department of General Practice and Polyclinic Therapy.</p><p>Moskovsky trakt, 2, Tomsk, 634050</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аргунова</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Argunova</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аргунова Юлия Александровна - кандидат медицинских наук, научный сотрудник лаборатории реабилитации нейрососудистой патологии отдела мультифокального атеросклероза.</p><p>Сосновый бульвар, 6, Кемерово, 650002</p></bio><bio xml:lang="en"><p>Argunova Yulia A. - PhD, researcher at the Rehabilitation Laboratory, Department of Multivessel and Polyvascular Diseases.</p><p>6, Sosnovy Blvd., Kemerovo, 650002</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное бюджетное научное учреждение Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний<country>Россия</country></aff><aff xml:lang="en">Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное государственное бюджетное образовательное учреждение высшего образования Сибирский государственный медицинский университет<country>Россия</country></aff><aff xml:lang="en">Siberian State Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>02</day><month>02</month><year>2019</year></pub-date><volume>7</volume><issue>4S</issue><fpage>66</fpage><lpage>74</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Трубникова О.А., Моськин Е.Г., Гарганеева Н.П., Аргунова Ю.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Трубникова О.А., Моськин Е.Г., Гарганеева Н.П., Аргунова Ю.А.</copyright-holder><copyright-holder xml:lang="en">Trubnikova O.A., Moskin E.G., Garganeeva N.P., Argunova Y.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nii-kpssz.com/jour/article/view/508">https://www.nii-kpssz.com/jour/article/view/508</self-uri><abstract><p>В статье представлен обзор литературных данных по проблеме профилактики послеоперационной когнитивной дисфункции после коронарного шунтирования. Авторы представили анализ литературных данных о возможности использования физической преабилитации и прежде всего аэробных физических тренировок в профилактике данного вида цереброваскулярных осложнений при выполнении коронарного шунтирования. В статье представлен обзор исследований, посвященных механизмам влияния физических тренировок в целом и на когнитивные функции. Особое внимание уделено обзору исследований по изучению церебропротективных механизмов аэробных физических тренировок на когнитивные функции. Обсуждаются перспективы использования аэробных физических тренировок перед коронарным шунтированием с позиций профилактики послеоперационной когнитивной дисфункции. </p></abstract><trans-abstract xml:lang="en"><p>The review encompasses the latest literature on the prevention of postoperative cognitive dysfunction after coronary artery bypass grafting. We performed an attempt to provide all existing data on the prospects of using physical prehabilitation, particularly aerobic exercise, for prevention of cerebrovascular complications during coronary artery bypass grafting. The article summarizes recent studies on the effects of exercise trainings on wellbeing and cognitive functions. Particular attention has been paid to the review of the studies stating the presence of cerebroprotective effects and mechanisms of aerobic exercise on cognitive function. The prospects of aerobic prehabilitation before coronary artery bypass grafting for prevention of postoperative cognitive dysfunction are discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>физическая преабилитация</kwd><kwd>аэробные тренировки</kwd><kwd>коронарное шунтирование</kwd><kwd>послеоперационная когнитивная дисфункция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>physical prehabilitation</kwd><kwd>aerobic exercise</kwd><kwd>coronary artery bypass grafting</kwd><kwd>postoperative cognitive dysfunction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Velazquez E. J., Lee, K. L., Deja M. A., Jain A., Sopko G., Marchenko A., Ali I. S., Pohost G., Gradinac S., Abraham W. T., Yii M., Prabhakaran D., Szwed H., Ferrazzi P., Petrie M. C., O'Connor C. M., Panchavinnin P., She L., Bonow R. O., Rankin G. R., Jones R. H., Rouleau J. L. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N. Engl. J. Med. 2011; 364 (17): 1607–1616. doi: 10.1056NEJMoa1100356.</mixed-citation><mixed-citation xml:lang="en">Velazquez E. J., Lee, K. L., Deja M. A., Jain A., Sopko G., Marchenko A., Ali I. S., Pohost G., Gradinac S., Abraham W. T., Yii M., Prabhakaran D., Szwed H., Ferrazzi P., Petrie M. C., O'Connor C. M., Panchavinnin P., She L., Bonow R. O., Rankin G. R., Jones R. H., Rouleau J. L. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N. Engl. J. Med. 2011; 364 (17): 1607–1616. doi: 10.1056/NEJMoa1100356.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hueb W., Lopes N., Gersh B. J., Soares P. , Machado L.A., Jatene F.B., Oliveira S.A., Ramires J.A. Ten-year follow-up survival of the Medicine, Angioplasty, or Surgery Study (MASS II): a randomized controlled clinical trial of 3 therapeutic strategies for multivessel coronary artery disease . Circulation. 2010; 122 (10): 949–957. doi: 10,1161/CIRCULATIONAHA.106.625475.</mixed-citation><mixed-citation xml:lang="en">Hueb W., Lopes N., Gersh B. J., Soares P. , Machado L.A., Jatene F.B., Oliveira S.A., Ramires J.A. Ten-year follow-up survival of the Medicine, Angioplasty, or Surgery Study (MASS II): a randomized controlled clinical trial of 3 therapeutic strategies for multivessel coronary artery disease . Circulation. 2010; 122 (10): 949–957. doi: 10,1161/CIRCULATIONAHA.106.625475.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Archbold R.A., Curzen N.P. Off-pump coronary artery bypass graft surgery: the incidence of postoperative atrial fibrillation. Heart. 2003; 89(10):1134-1137.</mixed-citation><mixed-citation xml:lang="en">Archbold R.A., Curzen N.P. Off-pump coronary artery bypass graft surgery: the incidence of postoperative atrial fibrillation. Heart. 2003; 89(10):1134-1137.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Patel N., Minhas J.S., Chung E.M. Risk factors associated with cognitive decline after cardiac surgery: A systematic review. Cardiovasc Neurol. 2015; 2015: 370612. doi: 10.1155/2015/370612.</mixed-citation><mixed-citation xml:lang="en">Patel N., Minhas J.S., Chung E.M. Risk factors associated with cognitive decline after cardiac surgery: A systematic review. Cardiovasc Psychiatry Neurol. 2015; 2015: 370612. doi: 10.1155/2015/370612.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">van Harten A.E., Scheeren T.W., Absalom A.R., Steinmetz J. A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia. Anaesthesia. 2012; 67:280–93. doi: 10 .1111/j.1365-2044.2011.07008.x.</mixed-citation><mixed-citation xml:lang="en">van Harten A.E., Scheeren T.W., Absalom A.R., Steinmetz J. A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia. Anaesthesia. 2012; 67:280–93. doi: 10 .1111/j.1365-2044.2011.07008.x.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Steinmetz J., Rasmussen L.S. Peri-operative cognitive dysfunction and protection. Anaesthesia. 2016; 71(Suppl 1): 58–63. doi: 10.1111/anae.13308.</mixed-citation><mixed-citation xml:lang="en">Steinmetz J., Rasmussen L.S. Peri-operative cognitive dysfunction and protection. Anaesthesia. 2016; 71(Suppl 1): 58–63.  doi: 10.1111/anae.13308.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Glumac S., Kardum G. , Karanović N. Prospective cohort evaluation of the cortisol response to cardiac surgery with occurrence of early postoperative cognitive decline. Med Sci Monit. 2018; 24: 977-986. doi: 10.12659/MSM.908251.</mixed-citation><mixed-citation xml:lang="en">Glumac S., Kardum G., Karanović N.   Prospective cohort evaluation of the cortisol response to cardiac surgery with occurrence of early postoperative cognitive decline. Med Sci Monit. 2018; 24: 977-986. doi: [10.12659/MSM.908251].</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pack Q.R., Goel K., Lahr B.D., Greason K.L., Squires R.W., Lopez-Jimenez F., Zhang Z., Thomas R.J. Participation in cardiac rehabilitation and survival after coronary artery bypass graft surgery: a community-based study. Circulation 2013; 128 (6): 590–7. doi: 10.1161/CIRCULATIONAHA.112.001365.</mixed-citation><mixed-citation xml:lang="en">Pack Q.R., Goel K., Lahr B.D., Greason K.L., Squires R.W., Lopez-Jimenez F., Zhang Z., Thomas R.J. Participation in cardiac rehabilitation and survival after coronary artery bypass graft surgery: a community-based study. Circulation 2013; 128 (6): 590–7. doi: 10 .1161/CIRCULATIONAHA.112.001365.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Помешкина С.А., Боровик И.В., Крикунова З.П., Коваленко Т.В., Трубникова О.А., Кондрикова Н.В., Барбараш О.А. Эффективность ранней физической реабилитации пациентов после коронарного шунтирования. Сибирский медицинский журнал (Иркутск). 2012; 3: 37–40.</mixed-citation><mixed-citation xml:lang="en">Pomeshkina S.A., Borovik I.V., Krikunova Z.P., Kovalenko T.V., Trubnikova O.A., Kondrikova N.V., Barbarash O.L. Efficiency of early physical rehabilitation after coronary bypass surgery. Siberian Medical Journal (Irkutsk). 2012; 3: 37–40. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Бокерия Л.А., Аронов Д.М. Российские клинические рекомендации. Коронарное шунтирование больных ишемической болезнью сердца: реабилитация и вторичная профилактика. Cardioсоматика. 2016; 7 (3-4); 5-71.</mixed-citation><mixed-citation xml:lang="en">Bokeriya L.A., Aronov D.M. Russian clinical guidelines. Coronary artery bypass grafting in patients with ischemic heart disease: rehabilitation and secondary prevention. Cardiosomatics. 2016; 7 (3-4); 5-71. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Arthur H.M., Daniels C., McKelvie R., Hirsh J., Rush B. Effect of a preoperative intervention on preoperative and postoperative outcomes in low-risk patients awaiting elective coronary artery bypass graft surgery. A randomized, controlled trial. Ann Intern Med. 2000; 133 (4): 253–62.</mixed-citation><mixed-citation xml:lang="en">Arthur H.M., Daniels C., McKelvie R., Hirsh J., Rush B. Effect of a preoperative intervention on preoperative and postoperative outcomes in low-risk patients awaiting elective coronary artery bypass graft surgery. A randomized, controlled trial. Ann Intern Med. 2000; 133 (4): 253–62.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Sawatzky J.A., Kehler D.S., Ready A.E., Lerner N., Boreskie S., Lamont D., Luchik D., Arora R.C., Duhamel T.A. Prehabilitation program for elective coronary artery bypass graft surgery patients: a pilot randomized controlled study. Clin Rehabil. 2014; 28 (7): 648–57. doi: 10.1177/0269215513516475.</mixed-citation><mixed-citation xml:lang="en">Sawatzky J.A., Kehler D.S., Ready A.E., Lerner N., Boreskie S., Lamont D., Luchik D., Arora R.C., Duhamel T.A. Prehabilitation program for elective coronary artery bypass graft surgery patients: a pilot randomized controlled study. Clin Rehabil. 2014; 28 (7): 648–57. doi: 10.1177/0269215513516475.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Herdy A.H., Marcchi P.L., Vila A., Tavares C., Collaço J., Niebauer J., Ribeiro J.P. Pre- and postoperative cardiopulmonary rehabilitation in hospitalized patients undergoing coronary artery bypass surgery: a randomized controlled trial. Am J Phys Med Rehabil. 2008; 87 (9): 714–9. doi: 10.1097/PHM.0b013e3181839152.</mixed-citation><mixed-citation xml:lang="en">Herdy A.H., Marcchi P.L., Vila A., Tavares C., Collaço J., Niebauer J., Ribeiro J.P. Pre- and postoperative cardiopulmonary rehabilitation in hospitalized patients undergoing coronary artery bypass surgery: a randomized controlled trial. Am J Phys Med Rehabil. 2008; 87 (9): 714–9. doi: 10.1097/PHM.0b013e3181839152.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Stammers A.N., Kehler D.S., Afilalo J., Avery L.J., Bagshaw S.M., Grocott H.P., Légaré J.F., Logsetty S., Metge C., Nguyen T., Rockwood K.0, Sareen J.1, Sawatzky J.A., Tangri N., Giacomantonio N., Hassan A., Duhamel T.A., Arora R.C. Protocol for the PREHAB study-Pre-operative rehabilitation for reduction of hospitalization after coronary bypass and valvular surgery: a randomised controlled trial. BMJ Open. 2015; 5(3):e007250. doi:10.1136/bmjopen-2014-007250.</mixed-citation><mixed-citation xml:lang="en">Stammers A.N., Kehler D.S., Afilalo J., Avery L.J., Bagshaw S.M., Grocott H.P., Légaré J.F., Logsetty S., Metge C., Nguyen T., Rockwood K.0, Sareen J.1, Sawatzky J.A., Tangri N., Giacomantonio N., Hassan A., Duhamel T.A., Arora R.C. Protocol for the PREHAB study-Pre-operative rehabilitation for reduction of hospitalization after coronary bypass and valvular surgery: a randomised controlled trial. BMJ Open. 2015; 5(3):e007250. doi:10.1136/bmjopen-2014-007250.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Moe G.W., Ezekowitz J.A., O'Meara E., Howlett J.G, Fremes SE, Al-Hesayen A, et al. The 2013 Canadian Cardiovascular Society Heart Failure Management Guidelines Update: focus on rehabilitation and exercise and surgical coronary revascularization. Can J Cardiol. 2014; 30(3):249– 263. doi: 10.1016/j.cjca.2013.10.010.</mixed-citation><mixed-citation xml:lang="en">Moe G.W., Ezekowitz J.A., O'Meara E., Howlett J.G, Fremes SE, Al-Hesayen A, et al. The 2013 Canadian Cardiovascular Society Heart Failure Management Guidelines Update: focus on rehabilitation and exercise and surgical coronary revascularization. Can J Cardiol. 2014; 30(3):249– 263. doi: 10.1016/j.cjca.2013.10.010.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Vanhees L., Rauch B., Piepoli M., van Buuren F., Takken T., Börjesson M., Bjarnason-Wehrens B., Doherty P., Dugmore D., Halle Mimportance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular disease (Part III). Eur J Prev Cardiol. 2012; 19(6): 1333–1356. doi: 10.1177/2047487312437063.</mixed-citation><mixed-citation xml:lang="en">Vanhees L., Rauch B., Piepoli M., van Buuren F., Takken T., Börjesson M., Bjarnason-Wehrens B., Doherty P., Dugmore D., Halle Mimportance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular disease (Part III). Eur J Prev Cardiol. 2012; 19(6): 1333–1356. doi: 10.1177/2047487312437063.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Adamopoulos S., Schmid J.P., Dendale P., Poerschke D., Hansen D., Dritsas A., Kouloubinis A., Alders T., Gkouziouta A., Reyckers I., Vartela V., Plessas N., Doulaptsis C., Saner H., Laoutaris I.D. Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure: The VentHeFT trial: a European prospective multicenter randomized trial. Eur J Heart Fail. 2014; 16(5): 574–582. doi: 10.1002/ejhf.70.</mixed-citation><mixed-citation xml:lang="en">Adamopoulos S., Schmid J.P., Dendale P., Poerschke D., Hansen D., Dritsas A., Kouloubinis A., Alders T., Gkouziouta A., Reyckers I., Vartela V., Plessas N., Doulaptsis C., Saner H., Laoutaris I.D. Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure: The VentHeFT trial: a European prospective multicenter randomized trial. Eur J Heart Fail. 2014; 16(5): 574–582. doi: 10.1002/ejhf.70.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Intlekofer K.A., Cotman C.W. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis. 2013; 57: 47-55. doi: 10,1016/j.nbd.2012.06.011.</mixed-citation><mixed-citation xml:lang="en">Intlekofer K.A., Cotman C.W. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis. 2013; 57: 47-55. doi: 10,1016/j.nbd.2012.06.011.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Erickson K. I., Voss M. W., Prakash R. S., Basak C., Szabo A., Chaddock L., Kim J.S., Heo S., Alves H., White S.M., Wojcicki T.R., Mailey E., Vieira V.J., Martin S.A., Pence B.D., Woods J.A., McAuley E, Kramer A.F. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. USA. 2011; 108(7):3017-22: doi:10.1073/pnas.1015950108.</mixed-citation><mixed-citation xml:lang="en">Erickson K. I., Voss M. W., Prakash R. S., Basak C., Szabo A., Chaddock L., Kim J.S., Heo S., Alves H., White S.M., Wojcicki T.R., Mailey E., Vieira V.J., Martin S.A., Pence B.D., Woods J.A., McAuley E, Kramer A.F. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. USA. 2011; 108(7):3017-22: doi: 10.1073/pnas.1015950108.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Brinke L.F., Bolandzadeh N., Nagamatsu L.S., Hsu C.L., Davis J.C., Miran-Khan K., Liu-Ambrose T. Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial. Br J Sports Med. 2015; 49(4): 248-54. doi: 10.1136/bjsports-2013-093184.</mixed-citation><mixed-citation xml:lang="en">Brinke L.F., Bolandzadeh N., Nagamatsu L.S., Hsu C.L., Davis J.C., Miran-Khan K., Liu-Ambrose T. Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial. Br J Sports Med. 2015; 49(4): 248-54. doi: 10.1136/bjsports-2013-093184.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Tamura M., Nemoto K., Kawaguchi A., Kato M., Arai T., Kakuma T., Mizukami K., Matsuda H., Soya H., Asada T. Long-term mild-intensity exercise regimen preserves prefrontal cortical volume against aging. Int. J. Geriatr. Psychiatry. 2015; 30: 686–694. doi: 10,1002/gps.4205.</mixed-citation><mixed-citation xml:lang="en">Tamura M., Nemoto K., Kawaguchi A., Kato M., Arai T., Kakuma T., Mizukami K., Matsuda H., Soya H., Asada T. Long-term mild-intensity exercise regimen preserves prefrontal cortical volume against aging. Int. J. Geriatr. Psychiatry. 2015; 30: 686–694. doi: 10,1002/gps.4205.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Frederiksen K.S., Larsen C.T., Hasselbalch S.G., Christensen A.N., Høgh P., Wermuth L., Andersen B.B., Siebner H.R., Garde E. A 16-week aerobic exercise intervention does not affect hippocampal volume and cortical thickness in mild to moderate Alzheimer's disease. Front Aging Neurosci. 2018;10:293. doi: 10.3389/fnagi.2018.00293.</mixed-citation><mixed-citation xml:lang="en">Frederiksen K.S., Larsen C.T., Hasselbalch S.G., Christensen A.N., Høgh P., Wermuth L., Andersen B.B., Siebner H.R., Garde E. A 16-week aerobic exercise intervention does not affect hippocampal volume and cortical thickness in mild to moderate Alzheimer's disease. Front Aging Neurosci. 2018;10:293. doi: 10.3389/fnagi.2018.00293.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Heyn P., Abreu B.C., Ottenbacher K.J. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil. 2004; 85(10):1694-704.</mixed-citation><mixed-citation xml:lang="en">Heyn P., Abreu B.C., Ottenbacher K.J. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil. 2004; 85(10):1694-704.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Aarsland D., Sardahaee F.S., Anderssen S., Ballard C. Is physical activity a potential preventive factor for vascular dementia? A systematic review. Aging Ment Health. 2010; 14(4):386-95. doi: 10.1080/13607860903586136.</mixed-citation><mixed-citation xml:lang="en">Aarsland D., Sardahaee F.S., Anderssen S., Ballard C. Is physical activity a potential preventive factor for vascular dementia? A systematic review. Aging Ment Health. 2010; 14(4):386-95. doi: 10.1080/13607860903586136.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Okonkwo O.C., Schultz S.A., Oh J.M., Larson J., Edwards D., Cook D., Koscik R., Gallagher C.L., Dowling N.M., Carlsson C.M., Bendlin B.B., La Rue A., Rowley H.A., Christian B.T., Asthana S., Hermann B.P., Johnson S.C., Sager M.A. Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology. 2014; 83(19):1753-60. doi: 10.1212/WNL.0000000000000964.</mixed-citation><mixed-citation xml:lang="en">Okonkwo O.C., Schultz S.A., Oh J.M., Larson J., Edwards D., Cook D., Koscik R., Gallagher C.L., Dowling N.M., Carlsson C.M., Bendlin B.B., La Rue A., Rowley H.A., Christian B.T., Asthana S., Hermann B.P., Johnson S.C., Sager M.A. Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology. 2014; 83(19):1753-60. doi: 10.1212/WNL.0000000000000964.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Merrill D.A., Siddarth P., Raji C.A., Emerson N.D., Rueda F., Ercoli L.M., Miller K.J., Lavretsky H., Harris L.M., Burggren A.C., Bookheimer S.Y., Barrio J.R., Small G.W. Modifiable risk factors and brain positron emission tomography measures of amyloid and tau in nondemented adults with memory complaints. Am J Geriatr Psychiatry. 2016; 24(9):72937. doi: 10.1016/j.jagp.2016.05.007.</mixed-citation><mixed-citation xml:lang="en">Merrill D.A., Siddarth P., Raji C.A., Emerson N.D., Rueda F., Ercoli L.M., Miller K.J., Lavretsky H., Harris L.M., Burggren A.C., Bookheimer S.Y., Barrio J.R., Small G.W. Modifiable risk factors and brain positron emission tomography measures of amyloid and tau in nondemented adults with memory complaints. Am J Geriatr Psychiatry. 2016; 24(9):729-37. doi: 10.1016/j.jagp.2016.05.007.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Baker L.D., Frank L.L., Foster-Schubert K., Green P.S., Wilkinson C.W., McTiernan A., Cholerton B.A., Plymate S.R., Fishel M.A., Watson G.S., Duncan G.E., Mehta P.D., Craft S. Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease. J Alzheimers Dis. 2010; 22(2):569-79. doi: 10.3233/JAD-2010-100768.</mixed-citation><mixed-citation xml:lang="en">Baker L.D., Frank L.L., Foster-Schubert K., Green P.S., Wilkinson C.W., McTiernan A., Cholerton B.A., Plymate S.R., Fishel M.A., Watson G.S., Duncan G.E., Mehta P.D., Craft S. Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease. J Alzheimers Dis. 2010; 22(2):569-79. doi: 10.3233/JAD-2010-100768.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Suzuki T., Shimada H., Makizako H., Doi T., Yoshida D., Ito K., Shimokata H., Washimi Y., Endo H., Kato T. A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS One. 2013; 8(4):e61483. doi: 10.1371/journal.pone.0061483.</mixed-citation><mixed-citation xml:lang="en">Suzuki T., Shimada H., Makizako H., Doi T., Yoshida D., Ito K., Shimokata H., Washimi Y., Endo H., Kato T. A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS One. 2013; 8(4):e61483. doi: 10.1371/journal.pone.0061483.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann K., Sobol N.A., Frederiksen K.S., Beyer N., Vogel A., Vestergaard K., Brændgaard H., Gottrup H., Lolk A., Wermuth L., Jacobsen S., Laugesen L.P., Gergelyffy R.G., Høgh P., Bjerregaard E., Andersen B.B., Siersma V., Johannsen P., Cotman C.W., Waldemar G., Hasselbalch S.G. Moderateto-high intensity physical exercise in patients with alzheimer's disease: a randomized controlled trial. J Alzheimers Dis. 2016; 50(2):443-53. doi: 10.3233/JAD-150817.</mixed-citation><mixed-citation xml:lang="en">Hoffmann K., Sobol N.A., Frederiksen K.S., Beyer N., Vogel A., Vestergaard K., Brændgaard H., Gottrup H., Lolk A., Wermuth L., Jacobsen S., Laugesen L.P., Gergelyffy R.G., Høgh P., Bjerregaard E., Andersen B.B., Siersma V., Johannsen P., Cotman C.W., Waldemar G., Hasselbalch S.G. Moderateto-high intensity physical exercise in patients with alzheimer's disease: a randomized controlled trial. J Alzheimers Dis. 2016; 50(2):443-53. doi: 10.3233/JAD-150817.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Köbe T., Witte A.V., Schnelle A., Lesemann A., Fabian S., Tesky V.A., Pantel J., Flöel A. Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. Neuroimage. 2016; 131: 226-38. doi: 10.1016/j.neuroimage.2015.09.050.</mixed-citation><mixed-citation xml:lang="en">Köbe T., Witte A.V., Schnelle A., Lesemann A., Fabian S., Tesky V.A., Pantel J., Flöel A. Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. Neuroimage. 2016; 131: 226-38. doi: 10.1016/j.neuroimage.2015.09.050.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ryan S. M., Kelly Á.M. Exercise as a pro-cognitive, proneurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease. Ageing Res. Rev. 27 77–92. doi: 10.1016/j.arr.2016.03.007.</mixed-citation><mixed-citation xml:lang="en">Ryan S. M., Kelly Á.M.  Exercise as a pro-cognitive, proneurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer’s disease. Ageing Res. Rev. 27 77–92. doi: 10.1016/j.arr.2016.03.007.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Moore K.M., Girens R.E., Larson S.K., Jones M.R., Restivo J.L., Holtzman D.M., Cirrito J.R., Yuede C.M., Zimmerman S.D., Timson B.F. A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease. Neurobiol Dis. 2016; 85: 218-224. doi: 10.1016/j.nbd.2015.11.004.</mixed-citation><mixed-citation xml:lang="en">Moore K.M., Girens R.E., Larson S.K., Jones M.R., Restivo J.L., Holtzman D.M., Cirrito J.R., Yuede C.M., Zimmerman S.D., Timson B.F. A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease. Neurobiol Dis. 2016; 85: 218-224.  doi: 10.1016/j.nbd.2015.11.004.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Kang E.B., Cho J.Y. Effect of treadmill exercise on PI3K/ AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice. J Exerc Nutrition Biochem. 2015; 19(3):199–209. doi: 10.5717/jenb.2015.15090806.</mixed-citation><mixed-citation xml:lang="en">Kang E.B., Cho J.Y. Effect of treadmill exercise on PI3K/ AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice. J Exerc Nutrition Biochem. 2015; 19(3):199–209. doi: 10.5717/jenb.2015.15090806.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Gleeson M., Bishop N. C., Stensel D.J., Lindley M. R., Mastana S. S., Nimmo M. A. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat. Rev. Immunol. 2011; 11: 607–615. doi: 10.1038/nri3041.</mixed-citation><mixed-citation xml:lang="en">Gleeson M., Bishop N. C., Stensel D.J., Lindley M. R., Mastana S. S., Nimmo M. A. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat. Rev. Immunol. 2011; 11: 607–615.  doi: 10.1038/nri3041.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">DiPenta J. M., Johnson J. G., Murphy R. J. Natural killer cells and exercise training in the elderly: a review. Can. J. Appl. Physiol. 2004; 29: 419–443. doi: 10.1139/h04-027.</mixed-citation><mixed-citation xml:lang="en">DiPenta J. M., Johnson J. G., Murphy R. J. Natural killer cells and exercise training in the elderly: a review. Can. J. Appl. Physiol. 2004; 29: 419–443. doi: 10.1139/h04-027.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kohut M.L., Senchina D.S. Reversing age-associated immunosenescence via exercise. Exerc. Immunol. Rev. 2004; 10: 6-41.</mixed-citation><mixed-citation xml:lang="en">Kohut M.L., Senchina D.S. Reversing age-associated immunosenescence via exercise. Exerc. Immunol. Rev. 2004; 10: 6-41.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Cotman C.W., Berchtold N.C., Christie L.A. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007; 30(9): 464-72. doi: 10.1016/j.tins.2007.06.011.</mixed-citation><mixed-citation xml:lang="en">Cotman C.W., Berchtold N.C., Christie L.A. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007; 30(9): 464-72. doi: 10.1016/j.tins.2007.06.011.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Ravaglia G., Forti P., Maioli F., Chiappelli M., Montesi F., Tumini E., Mariani E., Licastro F., Patterson C. Blood inflammatory markers and risk of dementia: the conselice study of brain aging. Neurobiol. 2007; 28(12): 1810–1820. doi: 0.1016/j.neurobiolaging.2006.08.012.</mixed-citation><mixed-citation xml:lang="en">Ravaglia G., Forti P., Maioli F., Chiappelli M., Montesi F., Tumini E., Mariani E., Licastro F., Patterson C. Blood inflammatory markers and risk of dementia: the conselice study of brain aging. Neurobiol. 2007; 28(12): 1810–1820. doi: 0.1016/j.neurobiolaging.2006.08.012.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Kohut M.L., McCann D.A., Russell D.W., Konopka D.N., Cunnick J.E., Franke W.D., Castillo M.C., Reighard A.E., Vanderah E. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun. 2006; 20(3): 201-9. doi:10.1016/j.bbi.2005.12.002.</mixed-citation><mixed-citation xml:lang="en">Kohut M.L., McCann D.A., Russell D.W., Konopka D.N., Cunnick J.E., Franke W.D., Castillo M.C., Reighard A.E., Vanderah E. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun. 2006; 20(3): 201-9. doi:10.1016/j.bbi.2005.12.002.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Daly R.M., O'Connell S.L., Mundell N.L., Grimes C.A., Dunstan D.W., Nowson C.A. Protein-enriched diet, with the use of lean red meat, combined with progressive resistance training enhances lean tissue mass and muscle strength and reduces circulating IL-6 concentrations in elderly women: a cluster randomized controlled trial. Am J Clin Nutr. 2014; 99(4):899910. doi: 10.3945/ajcn.113.064154.</mixed-citation><mixed-citation xml:lang="en">Daly R.M., O'Connell S.L., Mundell N.L., Grimes C.A., Dunstan D.W., Nowson C.A. Protein-enriched diet, with the use of lean red meat, combined with progressive resistance training enhances lean tissue mass and muscle strength and reduces circulating IL-6 concentrations in elderly women: a cluster randomized controlled trial. Am J Clin Nutr. 2014; 99(4):899910. doi: 10.3945/ajcn.113.064154.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Banks W.A., Kastin A.J., Gutierrez E.G. Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci Lett. 1994; 179(1-2):53-6.</mixed-citation><mixed-citation xml:lang="en">Banks W.A., Kastin A.J., Gutierrez E.G. Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci Lett. 1994; 179(1-2):53-6.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Baune B.T., Ponath G., Golledge J., Varga G., Arolt V., Rothermundt M., Berger K. Association between IL-8 cytokine and cognitive performance in an elderly general population the MEMO-Study. Neurobiol Aging. 2008; 29 (6):937-44. doi: 10,1016/j.neurobiolaging.2006.12.003.</mixed-citation><mixed-citation xml:lang="en">Baune B.T., Ponath G., Golledge J., Varga G., Arolt V., Rothermundt M., Berger K. Association between IL-8 cytokine and cognitive performance in an elderly general population-the MEMO-Study. Neurobiol Aging. 2008; 29 (6):937-44. doi: 10,1016/j.neurobiolaging.2006.12.003.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Tan Z. S., Beiser A. S., Vasan R. S., Roubenoff R., Dinarello C. A., Harris T. B., Benjamin E.J., Au R., Kiel D.P., Wolf P.A., Seshadri S. Inflammatory markers and the risk of Alzheimer disease: the Framingham study. Neurology. 2007; 68: 1902–1908. doi: 10.1212/01.wnl.0000263217.36439.da.</mixed-citation><mixed-citation xml:lang="en">Tan Z. S., Beiser A. S., Vasan R. S., Roubenoff R., Dinarello C. A., Harris T. B., Benjamin E.J., Au R., Kiel D.P., Wolf P.A., Seshadri S. Inflammatory markers and the risk of Alzheimer disease: the Framingham study. Neurology. 2007; 68: 1902–1908. doi: 10.1212/01.wnl.0000263217.36439.da.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Bonotis K., Krikki E., Holeva V., Aggouridaki C., Costa V., Baloyannis S. Systemic immune aberrations in Alzheimer’s disease patients. J. Neuroimmunol. 2008; 193: 183–187. doi:10.1016/j.jneuroim.2007.10.020.</mixed-citation><mixed-citation xml:lang="en">Bonotis K., Krikki E., Holeva V., Aggouridaki C., Costa V., Baloyannis S. Systemic immune aberrations in Alzheimer’s disease patients. J. Neuroimmunol. 2008; 193: 183–187. doi:10.1016/j.jneuroim.2007.10.020.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Michigan A., Johnson T. V., Master V. A. Review of the relationship between C-reactive protein and exercise. Mol. Diagn. Ther. 2011; 15: 265–275 doi: 10.2165/11593400-000000000-00000.</mixed-citation><mixed-citation xml:lang="en">Michigan A., Johnson T. V., Master V. A. Review of the relationship between C-reactive protein and exercise. Mol. Diagn. Ther. 2011; 15: 265–275 doi: 10.2165/11593400-000000000-00000.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips C., Baktir M.A., Srivatsan M., Salehi A. Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling. Front Cell Neurosci. 2014; 8:170. doi: 10.3389/fncel.2014.00170.</mixed-citation><mixed-citation xml:lang="en">Phillips C., Baktir M.A., Srivatsan M., Salehi A. Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling. Front Cell Neurosci. 2014; 8:170. doi:10.3389/fncel.2014.00170.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Аргунова Ю.А., Трубникова О.А., Мамонтова А.С., Сырова И.Д., Кухарева И.Н., Малева О.В., Барбараш О.Л. Влияние трехнедельного курса аэробных физических тренировок на нейродинамические показатели пациентов, перенесших коронарное шунтирование. Российский кардиологический журнал. 2016; 21 (2): 30-36. doi: 10.15829/1560-4071-2016-2-30-36.</mixed-citation><mixed-citation xml:lang="en">Argunova Y.A., Trubnikova O.A., Mamontova A.S., Syrova I.D., Kuhareva I.N., Maleva O.V., Barbarash O.L. The influence of three-week aerobic exercise program on neurodynamic parameters of patients underwent coronary bypass grafting. Russian Journal of Cardiology. 2016; (2):3036. (In Russian) doi.org/10.15829/1560-4071-2016-2-30-36.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Tarumi T., Zhang R. Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and aerobic fitness. J Neurochem. 2018; 144 (5): 595-608. doi: 10.1111/jnc.</mixed-citation><mixed-citation xml:lang="en">Tarumi T., Zhang R. Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and aerobic fitness. J Neurochem. 2018; 144 (5): 595-608. doi: 10.1111/jnc.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Chapman S.B., Aslan S., Spence J.S., Keebler M.W., DeFina L.F., Didehbani N., Perez A.M. , Lu H., D'Esposito M. Distinct brain and behavioral benefits from cognitive vs. physical training: A randomized trial in aging adults. Front Hum Neurosci. 2016; 10:338. doi:10.3389/fnhum.2016.00338.</mixed-citation><mixed-citation xml:lang="en">Chapman S.B., Aslan S., Spence J.S., Keebler M.W., DeFina L.F., Didehbani N., Perez A.M. , Lu H., D'Esposito M. Distinct brain and behavioral benefits from cognitive vs. physical training: A randomized trial in aging adults. Front Hum Neurosci. 2016; 10:338. doi:10.3389/fnhum.2016.00338.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Siepe M., Pfeiffer T., Gieringer A., Zemann S., Benk С., Schlensak С., Beyersdorf F. Increased systemic perfusion pressure during cardiopulmonary bypass is associated with less early postoperative cognitive dysfunction and delirium. Eur. J. Cardiothor. Surg. 2011; 40 (1): 200–207. doi: 10.1016/j.ejcts.2010.11.024.</mixed-citation><mixed-citation xml:lang="en">Siepe M., Pfeiffer T., Gieringer A., Zemann S., Benk С., Schlensak С., Beyersdorf F. Increased systemic perfusion pressure during cardiopulmonary bypass is associated with less early postoperative cognitive dysfunction and delirium. Eur. J. Cardiothor. Surg. 2011; 40 (1): 200–207. doi: 10.1016/j.ejcts.2010.11.024.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips C. Brain-derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection. Neural Plast. 2017; 2017: doi: 10.1155/2017/72601307260130.</mixed-citation><mixed-citation xml:lang="en">Phillips C. Brain-derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection. Neural Plast. 2017; 2017: doi: 10.1155/2017/72601307260130.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Dinoff A, Herrmann N, Swardfager W., Gallagher D., Lanctôt K.L. The effect of exercise training on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF): A meta-analysis. PLoS One. 2016; 11(9):e0163037. doi:10.1371/journal.pone.0163037.</mixed-citation><mixed-citation xml:lang="en">Dinoff A, Herrmann N, Swardfager W., Gallagher D., Lanctôt K.L. The effect of exercise training on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF): A meta-analysis. PLoS One. 2016; 11(9):e0163037. doi:10.1371/journal.pone.0163037.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Matura S., Fleckenstein J., Deichmann R., Engeroff T., Füzéki E., Hattingen E., Hellweg R., Lienerth B., Pilatus U., Schwarz S., Tesky V.A., Vogt L., Banzer W., Pantel J. Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial. Transl Psychiatry. 2017; 7(7):e1172. doi:10.1038/tp.2017.135</mixed-citation><mixed-citation xml:lang="en">Matura S., Fleckenstein J., Deichmann R., Engeroff T., Füzéki E., Hattingen E., Hellweg R., Lienerth B., Pilatus U., Schwarz S., Tesky V.A., Vogt L., Banzer W., Pantel J. Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial. Transl Psychiatry. 2017; 7(7):e1172. doi:10.1038/tp.2017.135</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips C. Physical activity modulates common neuroplasticity substrates in depressive and bipolar disorder. Neural Plasticity. 2017; 2017: 37. doi: 10.1155/2017/7014146.7014146</mixed-citation><mixed-citation xml:lang="en">Phillips C. Physical activity modulates common neuroplasticity substrates in depressive and bipolar disorder. Neural Plasticity. 2017; 2017: 37. doi: 10.1155/2017/7014146.7014146</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Gavin T.P., Kraus R.M., Carrithers J.A., Garry J.P., Hickner R.C. Aging and the skeletal muscle angiogenic response to exercise in women. J Gerontol A Biol Sci Med Sci. 2014; 70(10):1189-97. doi: 10.1093/gerona/glu138.</mixed-citation><mixed-citation xml:lang="en">Gavin T.P., Kraus R.M., Carrithers J.A., Garry J.P., Hickner R.C. Aging and the skeletal muscle angiogenic response to exercise in women. J Gerontol A Biol Sci Med Sci. 2014; 70(10):1189-97. doi: 10.1093/gerona/glu138.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
