kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2018-7-4S-75-85kpccz-509Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОРANALYTICAL REVIEWИзменчивость митохондриальной ДНК в развитии атеросклероза и инфаркта миокарда (обзор литературы)Variability of mitochondrial DNA in the development of atherosclerosis and myocardial infarction (a review)ПонасенкоА. В.PonasenkoA. V.

Понасенко Анастасия Валериевна - кандидат медицинских наук, заведующая лабораторией геномной медицины отдела экспериментальной и клинической кардиологии.

650002, Кемерово, Сосновый бульвар, 6

Ponasenko Anastasia V. - PhD, Head of the Laboratory of Genomic Medicine, Department of Experimental and Clinical Cardiology.

6, Sosnoviy Blvd., Kemerovo, 650002

ponaav@kemcardio.ruЦепокинаА. В.TsepokinaA. V.

Цепокина Анна Викторовна - младший научный сотрудник лаборатории геномной медицины отдела экспериментальной и клинической кардиологии.

650002, Кемерово, Сосновый бульвар, 6

Tsepokina Anna V. - researcher assistant, Laboratory of Genomic Medicine, Department of Experimental and Clinical Cardiology.

6, Sosnoviy Blvd., Kemerovo, 650002

ТхоренкоБ. А.TkhorenkoB. A.

Тхоренко Борис Александрович - лаборант-исследователь лаборатории геномной медицины отдела экспериментальной и клинической кардиологии.

650002, Кемерово, Сосновый бульвар, 6

Tkhorenko Boris A. - assistant at the Laboratory of Genomic Medicine, Department of Experimental and Clinical Cardiology.

6, Sosnoviy Blvd., Kemerovo, 650002

ГолубенкоМ. В.GolubenkoM. V.

Голубенко Мария Владимировна - кандидат биологических наук, старший научный сотрудник лаборатории популяционной генетики.

634050, Томск, ул. Набережная реки Ушайки, 10

Golubenko Maria V. - PhD, senior researcher at the Laboratory of Population Genetics.

10, Ushaika embankment, Tomsk, 634050

ГубиеваЕ. К.GubievaE. K.

Губиева Екатерина Константиновна - студентка 4-го курса института биологии, экологии и природных ресурсов.

650000, Кемерово, ул. Красная, 6

Gubieva Ekaterina K. - a student at the Institute of Biology, Ecology and Natural Resources.

6, Krasnaya street, Kemerovo, 650000

ТрефиловаЛ. П.TrephilovaL. P.

Трефилова Людмила Павловна - студентка 4-го курса института биологии, экологии и природных ресурсов.

650000, Кемерово, ул. Красная, 6

Trefilova Lyudmila P. - a student at the Institute of Biology, Ecology and Natural Resources.

6, Krasnaya street, Kemerovo, 650000

Федеральное государственное бюджетное научное учреждение Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийРоссияFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular DiseasesRussian FederationНаучноисследовательский институт медицинской генетики, Федеральное государственное бюджетное научное учреждение Томский национальный исследовательский медицинский центр Российской академии наукРоссияResearch Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of SciencesRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования Кемеровский государственный университетРоссияKemerovo State UniversityRussian Federation20180202201974S7585Copyright © Понасенко А.В., Цепокина А.В., Тхоренко Б.А., Голубенко М.В., Губиева Е.К., Трефилова Л.П., 20202020Понасенко А.В., Цепокина А.В., Тхоренко Б.А., Голубенко М.В., Губиева Е.К., Трефилова Л.П.Ponasenko A.V., Tsepokina A.V., Tkhorenko B.A., Golubenko M.V., Gubieva E.K., Trephilova L.P.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/509

В статье обсуждаются ключевые вопросы о связи качественных и количественных характеристик мтДНК и риска развития атеросклероза и инфаркта миокарда. Проанализированы российские и зарубежные научные публикации, посвященные точковым и делеционным мутациям мтДНК и гетероплазмии в связи с рисками развития сердечно-сосудистых заболеваний и острых сердечно-сосудистых катастроф. Также обсуждается взаимосвязь между кардиоваскулярными событиями и выраженностью оксидативного стресса, количеством копий мтДНК как в клетках, так и в плазме крови.

The article discusses key issues on the relationship between the qualitative and quantitative characteristics of mtDNA and the risks of atherosclerosis and myocardial infarction. Russian and international research literature was analyzed regarding point and deletion mutations in mtDNA, including heteroplasmy, related to the risks of developing cardiovascular diseases and acute cardiovascular events. The review also discusses the relationship between cardiovascular events and oxidative stress severity, the number of intracellular and free-circulating mtDNA copies.

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The authors declare that there are no conflicts of interest present.