References

kpccz

Комплексные проблемы сердечно-сосудистых заболеваний

Complex Issues of Cardiovascular Diseases

2306-12782587-9537

Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”

10.17802/2306-1278-2020-9-1-92-102

kpccz-677

Research Article

АНАЛИТИЧЕСКИЙ ОБЗОР. Патологическая физиология

REVIEWS. Pathological physiology

Скаффолды как системы доставки биологически активных и лекарственных веществ

Scaffolds as drug and bioactive compound delivery systems

https://orcid.org/0000-0002-8815-9651

Егорихина

М. Н.

Egorikhina

M. N.

Егорихина Марфа Николаевна- кандидат биологических наук, старший научный сотрудник научно-исследовательского института экспериментальной онкологии и биомедицинских технологий федерального государственного бюджетного образовательного учреждения высшего образования «Приволжский исследовательский медицинский университет».

пл. Минина и Пожарского, 10/1, Нижний Новгород, Российская Федерация, 603005

Egorikhina Marfa N.- Ph.D, senior researcher at the Laboratory of Regenerative Medicine at the Institute of Biomedical Technologies, Federal State Budgetary Educational Institution of Higher Education "Privolzhsky Research Medical University" of the Ministry of Healthcare.

10/1, Minin and Pozharsky Sq., Nizhny Novgorod, Russian Federation, 603950

https://orcid.org/0000-0002-0654-2631

Мухина

П. А.

Mukhina

P. A.

Мухина Полина Алексеевна- магистрант второго года обучения кафедры молекулярной биологии и иммунологии института биологии и биомедицины федерального государственного автономного образовательного учреждения высшего образования «Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского».

пр. Гагарина, 23, Нижний Новгород, Российская Федерация, 603950

Muhina Polina A.- 2-year master's student at the Department of Molecular Biology and Immunology, Institute of Biology and Biomedicine, Federal State Autonomous Educational Institution of Higher Education "National Research Nizhny Novgorod State University named after N.I. Lobachevsky".

23, Gagarin Av., Nizhnij Novgorod, Russian Federation, 603950

https://orcid.org/0000-0003-3732-4896

Бронникова

И. И.

Bronnikova

I. I.

Бронникова Ирина Ивановна, магистрант второго года обучения кафедры молекулярной биологии и иммунологии института биологии и биомедицины федерального государственного автономного образовательного учреждения высшего образования «Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского».

пр. Гагарина, 23, Нижний Новгород, Российская Федерация, 603950

Bronnikova Irina I.- 2-year master's student at the Department of Molecular Biology and Immunology, Institute of Biology and Biomedicine, Federal State Autonomous Educational Institution of Higher Education "National Research Nizhny Novgorod State University named after N.I. Lobachevsky".

23, Gagarin Av., Nizhnij Novgorod, Russian Federation, 603950

Федеральное государственное бюджетное образовательное учреждение высшего образования «Приволжский исследовательский медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияPrivolzhsky Research Medical UniversityRussian Federation

Федеральное государственное автономное образовательное учреждение высшего образования «Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского»РоссияLobachevsky State UniversityRussian Federation

2020

25032020

9192102

2020

Егорихина М.Н., Мухина П.А., Бронникова И.И.

Egorikhina M.N., Mukhina P.A., Bronnikova I.I.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nii-kpssz.com/jour/article/view/677

В статье проанализированы и систематизированы современные данные об использовании скаффолдов как систем контролируемой доставки веществ. Рассматриваются предпосылки и основания для использования скаффолдов в качестве систем доставки. Обсуждаются текущие стратегии создания систем контролируемой доставки биологически активных и лекарственных веществ на основе продуктов скаффолд-технологий. Приводится классификация систем доставки веществ на основе скаффолдов. Отдельное внимание уделено разработкам двухфазных систем доставки веществ с использованием наночастиц. Показано разнообразие наночастиц и их преимущества как носителей веществ, применяемых в двухкомпонентных системах доставки. Приводятся современные примеры разработок систем доставки веществ и перспективы развития регенеративной медицины.

The article updates the existing data on the use of scaffolds as target and controlled substance delivery systems. The prerequisites and grounds for using scaffolds as substance delivery systems are being considered. Current tissue-engineered strategies for developing target drug and bioactive substance delivery using scaffolds are being discussed. A classification of scaffold-based substance delivery systems is provided. Special attention is given to the development of two-phase substance delivery systems using various types of nanoparticles. A variety of nanoparticles and the benefits of their use as carriers of substances in a two-component delivery systems are shown. Recent developments in the substance delivery systems for regenerative medicine and future prospects are presented.

скаффолдбиологически активные веществалекарственные веществасистемы контролируемой доставки веществ

scaffoldbiologically active substancesmedicinal substancescontrolled substance delivery systems

References1

Park U., Kim K. Multiple growth factor delivery for skin tissue engineering applications. Biotechnol Bioprocess Eng. 2017; 22 (6): 659–670. doi:10.1007/s12257-017-0436-1

Azevedo H.S., Pashkuleva I. Biomimetic supramolecular designs for the controlled release of growth factors in bone regeneration. Adv Drug Deliv Rev. 2015; 94: 63–76. doi:10.1016/j.addr.2015.08.003

Kim H.S., Sun X., Lee J.H., Kim H.W., Fu X., Leong K.W. Advanced drug delivery systems and artificial skin grafts for skin wound healing. Adv Drug Deliv Rev. 2019; 146: 209– 239. doi:10.1016/j.addr.2018.12.014

Davoodi P., Lee L.Y., Xu Q., Sunil V., Sun Y., Soh S., Wang C.H. Drug delivery systems for programmed and on-demand release. Adv Drug Deliv Rev. 2018; 132: 104–138. doi:10.1016/j.addr.2018.07.002

Sarigol-Calamak E., Hascicek C. Tissue scaffolds as a local drug delivery system for bone regeneration. Adv Exp Med Biol. 2018; 1078: 475–493. doi:10.1007/978-981-13-0950-2_25

Carmagnola I., Ranzato E., Chiono V. Scaffold functionalization to support a tissue biocompatibility. In: Functional 3D Tissue Engineering Scaffolds. Materials, Technologies and Applications. Deng Y., Kuiper J., editors. Elsevier Ltd. 2018; p. 255–277. doi:10.1016/B978-0-08-100979-6.00011-2

Sane M.S., Misra N., Quintanar N.M., Jones C.D. Biochemical characterization of pure dehydrated binate amniotic membrane: role of cytokines in the spotlight. Regen Med. 2018; 13: 689–703. doi:10.2217/rme-2018-0085

Han G., Ceilley R. Chronic wound healing: a review of current management and treatments. Adv Ther. 2017; 34 (3): 599–610. doi:10.1007/s12325-017-0478-y

Park J.W., Hwang S.R., Yoon I.S. Advanced growth factor delivery systems in wound management and skin regeneration. Molecules. 2017; 22 (8): 1–20. doi:10.3390/molecules22081259

Evrova O., Buschmann J. In vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review. Eur Cells Mater. 2017; 34: 15–39. doi:10.22203/eCM.v034a02

Xu X., Zheng L., Yuan Q., Zhen G., Crane J.L., Zhou X., Cao X. Transforming growth factor-β in stem cells and tissue homeostasis. Bone Res. 2018; 6 (2): 1–31. doi:10.1038/s41413-017-0005-4

Karaman S., Leppanen V.M., Alitalo K. Vascular endothelial growth factor signaling in development and disease. Dev. 2018; 145 (14): 1–8. doi:10.1242/dev.151019

Bikle D.D., Tahimic C., Chang W., Wang Y., Philippou A., Barton E.R. Role of IGF-I signaling in muscle bone interactions. Bone. 2015; 80: 79–88. doi:10.1016/j.bone.2015.04.036

Maddaluno L., Urwyler C., Werner S. Fibroblast growth factors: key players in regeneration and tissue repair. Dev. 2017; 144 (22): 4047–4060. doi:10.1242/dev.152587

Seeger M.A., Paller A.S. The roles of growth factors in keratinocyte migration. Adv Wound Care. 2015; 4 (4): 213– 224. doi:10.1089/wound.2014.0540

El Bialy I., Jiskoot W., Reza Nejadnik M. Formulation, delivery and stability of bone morphogenetic proteins for effective bone regeneration. Pharm Res. 2017; 34 (6): 1152– 1170. doi:10.1007/s11095-017-2147-x

Kang J.M., Yoon J.K., Oh S.J., Kim B.S., Kim S.H. Synergistic therapeutic effect of three-dimensional stem cell clusters and angiopoietin-1 on promoting vascular regeneration in ischemic region. Tissue Eng. (Part A). 2018; 24 (7-8): 616– 630. doi:10.1089/ten.tea.2017.0260

Russow G., Jahn D., Appelt J., Mardian S., Tsitsilonis S., J. Keller. Anabolic therapies in osteoporosis and bone regeneration. Int J Mol Sci. 2018; 20 (1): 1–17. doi:10.3390/ijms20010083

Julier Z., Park A.J., Briquez P.S., Martino M.M. Promoting tissue regeneration by modulating the immune system. Acta Biomater. 2017; 53: 13–28. doi:10.1016/j.actbio.2017.01.056

Graiet H., Lokchine A., Francois P., Velier M., Grimaud F., Loyens M., Berda-Haddad Y., Veran J., Dignat-George F., Sabatier F., Magalon J. Use of platelet-rich plasma in regenerative medicine: technical tools for correct quality control. BMJ Open Sport Exerc Med. 2018; 4 (1): 1111–1115. doi:10.1136/bmjsem-2018-000442

Burnouf T., Strunk D., Koh M.B.C., Schallmoser K. Human platelet lysate: replacing fetal bovine serum as a gold standard for human cell propagation? Biomaterials. 2016; 76: 371–387. doi:10.1016/j.biomaterials.2015.10.065

Ramaswamy Reddy S.H., Reddy R., Babu N.C., Ashok G.N. Stem-cell therapy and platelet-rich plasma in regenerative medicines: a review on pros and cons of the technologies. J Oral Maxillofac Pathol. 2018; 22 (3): 367–374. 23. Samadi P., Sheykhhasan M., Khoshinani H.M. The use of platelet-rich plasma in aesthetic and regenerative medicine: a comprehensive review. Aesthetic Plast Surg. 2018; 43: 803– 814. doi:10.1007/s00266-018-1293-9

Yuasa M., Yamada T., Taniyama T., Masaoka T., Xuetao W., Yoshii T., Horie M., Yasuda H., Uemura T., Okawa A., Sotome S. Dexamethasone enhances osteogenic differentiation of bone marrow-and muscle-derived stromal cells and augments ectopic bone formation induced by bone morphogenetic protein-2. Plos One. 2015; 10 (2): 1–23. doi:10.1371/journal.pone.0116462

Ortiz de Montellano P.R. Cytochrome P450-activated prodrugs. Future Med Chem. 2013; 5 (2): 213–228. doi:10.4155/ fmc.12.197

Williams D.F. Challenges with the development of biomaterials for sustainable tissue engineering. Front Bioeng Biotechnol. 2019; 7: 1–10. doi:10.3389/fbioe.2019.00127

Eltom A., Zhong G., Muhammad A. Scaffold techniques and designs in tissue engineering functions and purposes: a review. Adv Mater Sci Eng. 2019; 2019: 1–13. doi:10.1155/2019/3429527

Bruzauskaite I., Bironaite D., Bagdonas E., Bernotiene E. Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects. Cytotechnology. 2016; 68 (3): 355–369. doi:10.1007/s10616-015-9895-4

Chen F.M., Zhang M., Wu Z.F. Toward delivery of multiple growth factors in tissue engineering. Biomaterials. 2010; 31 (24): 6279–6308. doi:10.1016/j.biomaterials.2010.04.053

Sun Y., Han X., Wang X., Zhu B., Li B., Chen Z., Ma G., Wan M. Sustained release of IGF-1 by 3D mesoporous scaffolds promoting cardiac stem cell migration and proliferation. Cell Physiol Biochem. 2018; 49: 2358–2370. doi:10.1159/000493836

Dorati R., DeTrizio A., Modena T., Conti B., Benazzo F., Gastaldi G., Genta I. Biodegradable scaffolds for bone regeneration combined with drug-delivery systems in osteomyelitis therapy. Pharmaceuticals. 2017; 10 (4): 1–21. doi:10.3390/ph10040096

Muhleder S., Pill K., Schaupper M., Labuda K., Priglinger E., Hofbauer P., Charwat V., Marx U., Redl H., Holnthoner W. The role of fibrinolysis inhibition in engineered vascular networks derived from endothelial cells and adiposederived stem cells. Stem Cell Res Ther. 2018; 9 (1): 1–13. doi:10.1186/s13287-017-0764-2

Safari J., Zarnegar Z. Advanced drug delivery systems: nanotechnology of health design a review. J Saudi Chem Soc. 2014; 18 (2): 85–99. doi:10.1016/j.jscs.2012.12.009

Brudno Y., Mooney D.J. On-demand drug delivery from local depots. J Control Release. 2015; 219: 8–17. doi:10.1016/j. jconrel.2015.09.011

Kim S., Chen Y., Ho E.A., Liu S. Reversibly pHresponsive polyurethane membranes for on-demand intravaginal drug delivery. Acta Biomater. 2017; 47: 100–112. doi:10.1016/j. actbio.2016.10.006

Wei L., Chen J., Zhao S., Ding J., Chen X. Thermosensitive polypeptide hydrogel for locally sequential delivery of two-pronged antitumor drugs. Acta Biomater. 2017; 58: 44–53. doi:10.1016/j.actbio.2017.05.053

Mitchell A.C., Briquez P.S., Hubbell J.A., Cochran J.R. Engineering growth factors for regenerative medicine applications. Acta Biomater. 2016; 30: 1–12. doi:10.1016/j. actbio.2015.11.007

Atienza-roca P., Cui X., Hooper G.J., Woodfield T.B.F., Lim K.S. Growth factor delivery systems for tissue engineering and regenerative medicine. Adv Exp Med Biol. 2018; 1078: 245–269. doi:10.1007/978-981-13-0950-2_13

Draenert F.G., Nonnenmacher A.L., Kämmerer P.W., Goldschmitt J., Wagner W. BMP-2 and bFGF release and in vitro effect on human osteoblasts after adsorption to bone grafts and biomaterials. Clin Oral Implants Res. 2012; 24 (7): 750– 757. doi:10.1111/j.1600-0501.2012.02481.x

Wang Z., Wang Z., Lu W.W., Zhen W., Yang D., Peng S. Novel biomaterial strategies for controlled growth factor delivery for biomedical applications. NPG Asia Mater. 2017; 9 (10): e435. doi:10.1038/am.2017.171

Huang S., Yang Y., Yang Q., Zhao Q., Ye X. Engineered circulatory scaffolds for building cardiac tissue. J Thorac Dis. 2018; 10 (20): 2312–2328. doi:10.21037/jtd.2017.12.92

Bouyer M., Guillot R., Lavaud J., Plettinx C., Olivier C., Curry V., Boutonnat J., Coll J.L., Peyrin F., Josserand V., Bettega G., Picart C. Surface delivery of tunable doses of BMP2 from an adaptable polymeric scaffold induces volumetric bone regeneration. Biomaterials. 2016; 104: 168–181. doi:10.1016/j. biomaterials.2016.06.001

Venkanna A., Kwon O.W., Afzal S., Jang C., Cho K.H., Yadav D.K., Kim K., Park H.G., Chun K.H., Kim S.Y., Kim M.H. Pharmacological use of a novel scaffold, anomeric N,Ndiarylamino tetrahydropyran: molecular similarity search, chemocentric target profiling, and experimental evidence. Sci Rep. 2017; 7 (1): 1–17. doi:10.1038/s41598-017-12082-3

Awada H.K., Johnson N.R., Wang Y. Sequential delivery of angiogenic growth factors improves revascularization and heart function after myocardial infarction. J Control Release. 2015; 207: 7–17. doi:10.1016/j.jconrel.2015.03.034

Fathi-Achachelouei M., Knopf-Marques H., Ribeiro da Silva C.E., Barthes J., Bat E., Tezcaner A., Vrana N.E. Use of nanoparticles in tissue engineering and regenerative medicine. Front Bioeng Biotechnol. 2019; 7 (113): 1–22. doi:10.3389/fbioe.2019.00113

Tan H.L., Teow S.Y., Pushpamalar J. Application of metal nanoparticle–hydrogel composites in tissue regeneration. Bioengineering. 2019; 6 (17): 1–18. doi:10.3390/ bioengineering6010017

Gao M., Chen J., Lin G., Li S., Wang L., Qin A., Zhao Z., Ren L., Wang Y., Tang B.Z. Long-term tracking of the osteogenic differentiation of mouse BMSCs by aggregationinduced emission nanoparticles. ACS Appl Mater Interfaces. 2016; 8 (28): 17878–17884. doi:10.1021/acsami.6b05471

Tang Z., He C., Tian H., Ding J., Hsiao B.S., Chu B., Chen X. Polymeric nanostructured materials for biomedical applications. Prog Polym Sci. 2016; 60: 86–128. doi:10.1016/j. progpolymsci.2016.05.005

Hasan A., Morshed M., Memic A., Hassan S., Webster T.J., Marei H.E.S. Nanoparticles in tissue engineering: applications, challenges and prospects. Int J Nanomedicine. 2018; 13: 5637–5655. doi:10.2147/IJN.S153758

Ali Y., Alqudah A., Ahmad S., Abd Hamid S., Farooq U. Macromolecules as targeted drugs delivery vehicles: an overview. Des Monomers Polym. 2019; 22 (1): 91–97. doi:10.1 080/15685551.2019.1591681

Nicolas J., Mura S., Brambilla D., MacKiewicz N., Couvreur P. Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymerbased nanocarriers for drug delivery. Chem Soc Rev. 2013; 42 (3): 1147–1235. doi:10.1039/c2cs35265f

Herranz-Blanco B., Ginestar E., Zhang H., Hirvonen J., Santos H.A. Microfluidics platform for glass capillaries and its application in droplet and nanoparticle fabrication. Int J Pharm. 2017; 516 (1-2): 100–105. doi:10.1016/j.ijpharm.2016.11.024

Jayaraman P., Gandhimathi C., Venugopal J.R., Becker D.L., Ramakrishna S., Srinivasan D.K. Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering. Adv Drug Deliv Rev. 2015; 94: 77–95. doi:10.1016/j.addr.2015.09.007

Lin T.W., Chien Y., Lin Y.Y., Wang M.L., Yarmishyn A.A., Yang Y.P., Hwang D.K., Peng C.H., Hsu C.C., Chen S.J., Chien K.H. Establishing liposome-immobilized dexamethasonereleasing PDMS membrane for the cultivation of retinal pigment epithelial cells and suppression of neovascularization. Int J Mol Sci. 2019; 20 (2): 1–17. doi:10.3390/ijms20020241

Li Y., Bai Y., Pan J., Wang H., Li H., Xu X., Fu X., Shi R., Luo Z., Li Y., Li Q., Fuh J.Y.H., Wei S. A hybrid 3D-printed aspirinladen liposome composite scaffold for bone tissue engineering. J Mater Chem B. 2019; 7: 619–629. doi:10.1039/C8TB02756K

Chen Y., Chen S., Kawazoe N., Chen G. Promoted angiogenesis and osteogenesis by dexamethasone-loaded calcium phosphate nanoparticles/collagen composite scaffolds with microgroove networks. Sci Rep. 2018; 8 (1): 1–12. doi:10.1038/ s41598-018-32495-y

The authors declare that there are no conflicts of interest present.