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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kpccz</journal-id><journal-title-group><journal-title xml:lang="ru">Комплексные проблемы сердечно-сосудистых заболеваний</journal-title><trans-title-group xml:lang="en"><trans-title>Complex Issues of Cardiovascular Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2306-1278</issn><issn pub-type="epub">2587-9537</issn><publisher><publisher-name>Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17802/2306-1278-2020-9-3-59-68</article-id><article-id custom-type="elpub" pub-id-type="custom">kpccz-758</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АНАЛИТИЧЕСКИЙ ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANALYTICAL REVIEW</subject></subj-group></article-categories><title-group><article-title>Миокардиальное повреждение при некардиальной хирургии: трудности диагностики</article-title><trans-title-group xml:lang="en"><trans-title>Myocardial injury in noncardiac surgery – diagnostic difficulties</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7124-1918</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мурашко</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Murashko</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, заместитель главного врача по медицинской части, Мичуринский проспект, 6, стр. 15, Москва, 119285;</p><p>доцент кафедры анестезиологии и реаниматологии, ул. Маршала Тимошенко, 19, стр. 1А, Москва, 121359</p></bio><bio xml:lang="en"><p>PhD, Deputy chief physician, 6/15, Michurinskij pr., Moscow, 119285;</p><p>associate Professor at the Department of Anesthesiology and Resuscitation, Marshala Timoshenko St., 19/1a, Moscow, Russian Federation, 121359</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8121-4160</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пасечник</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Pasechnik</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедрой анестезиологии и реаниматологии, </p><p>ул. Маршала Тимошенко, 19, стр. 1А, Москва, 121359</p></bio><bio xml:lang="en"><p>MD., Professor, Head of the Department of Anesthesiology and Intensive Care,</p><p>Marshala Timoshenko St., 19/1a, Moscow, 121359</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1002-1895</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бернс</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Berns</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор кафедры внутрен-них болезней стоматологического факультета,</p><p>ул. Делегатская, 20, стр.1, Москва, 127473</p></bio><bio xml:lang="en"><p>MD, Professor at the Department of Internal Diseases of the Dental Faculty, </p><p>20/1, Delegatskaya, Moscow, 127473</p></bio><email xlink:type="simple">svberns@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Федеральное государственное бюджетное учреждение «Объединенная больница с поликлиникой» Управления делами Президента Российской Федерации;&#13;
Федеральное государственное бюджетное учреждение дополнительного профессионального образования «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Central Clinical Hospital with Outpatient Clinic at the Department for Presidential Affairs;&#13;
Central State Medical Academy at the Department for Presidential Affairs<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Федеральное государственное бюджетное учреждение дополнительного профессионального образования «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Central State Medical Academy at the Department for Presidential Affairs<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет имени А.И. Евдокимова» Министерства здравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Federal State Budgetary Educational Institution of the Higher Education “A.I. Yevdokimov Moscow State University of Medicine and Dentistry” of the Ministry of Healthcare of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2020</year></pub-date><volume>9</volume><issue>3</issue><fpage>59</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мурашко С.С., Пасечник И.Н., Бернс С.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Мурашко С.С., Пасечник И.Н., Бернс С.А.</copyright-holder><copyright-holder xml:lang="en">Murashko S.S., Pasechnik I.N., Berns S.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nii-kpssz.com/jour/article/view/758">https://www.nii-kpssz.com/jour/article/view/758</self-uri><abstract><p>Перипроцедурное миокардиальное повреждение после кардио- и некардиохирургических вмешательств, отличное от инфаркта миокарда, – новое понятие, принятое в 2018 г. согласительным международным документом «Четвертое универсальное определение инфаркта миокарда».</p><p>Диагностика инфаркта и повреждения миокарда после некардиальных хирургических вмешательств затруднена.</p><p>Миокардиальное повреждение увеличивает послеоперационную летальность и ухудшает отдаленный прогноз и качество лечения.</p><p>Качество оказания хирургической помощи определяется не только техникой, но и течением послеоперационного периода. Осложнения зачастую нивелируют результаты успешно выполненной операции, при этом необходимо понимать, что многие осложнения не зависят непосредственно от хирурга. Развитие осложнений, определяющих исход лечения, может быть связано с кардиальной патологией. Причин кардиальных осложнений много: имеющаяся сопутствующая патология, нестабильность гемодинамики во время оперативного вмешательства, кардиотоксическое действие лекарственных препаратов и другие. Риск кардиальной смерти после внесердечных хирургических вмешательств в 40% случаев связан с периоперационными инфарктом миокарда (ИМ) или миокардиальным повреждением. ИМ является наиболее демонстративным осложнением, хотя и имеющим трудности в диагностике в периоперационном периоде в связи с зачастую асимптомным течением. Связь послеоперационного ИМ с летальностью сомнений не вызывает. В опубликованных в 2018 г. международных рекомендациях «Четвертое универсальное определение инфаркта миокарда» перипроцедурное миокардиальное повреждение после кардио- и некардиохирургических вмешательств отделено от ИМ и выделено в отдельную проблему. Диагностировать миокардиальное повреждение можно только с помощью лабораторных тестов, при этом само по себе повреждение миокарда ухудшает показатели послеоперационной летальности, отдаленный прогноз и качество жизни пациентов. В данном обзоре отражены особенности этиопатогенетических механизмов кардиальных осложнений в условиях оказания хирургической помощи, многофакторный генез повреждения миокарда. Приведен анализ современной научной литературы по диагностике миокардиального повреждения. Показана необходимость ранней диагностики повреждения миокарда для создания оптимальной тактики ведения больных при некардиохирургических вмешательствах.</p></abstract><trans-abstract xml:lang="en"><p>A new concept was adopted by the Fourth Universal Definition of MI Expert Consensus Document in 2018 – periprocedural myocardial injury after cardiac- and noncardiac interventions, which is distinct from myocardial infarction.</p><p>It is difficult to diagnose a heart attack and myocardial damage after noncardiac surgery.</p><p>Postoperative myocardial injury increases mortality and worsens the long-term prognosis and quality of treatment.</p><p>The quality of surgical care is determined by surgical techniques and the course of the postoperative period. Although complications often negate the results of brilliantly performed surgery, many of them would happen irrespective of surgeon`s actions. The development of complications determining the outcome of treatment can be associated with cardiac pathology. Cardiac complications may develop due to existing comorbidities, hemodynamic instability during surgery, cardiotoxic effect of drugs, etc. In 40% of cases, the risk of cardiac death after noncardiac surgery is associated with the development of perioperative myocardial infarction or myocardial injury. Myocardial infarction is the most demonstrative complication, although it is difficult to diagnose in the perioperative period in case of asymptomatic course. The link between postoperative myocardial infarction and lethality is beyond doubt. Adopted in 2018, the Fourth Universal Definition of MI Expert Consensus Document introduced a new concept of periprocedural myocardial injury after cardiac- and noncardiac interventions, which are distinct from myocardial infarction. Myocardial injury requires laboratory tests to be diagnosed. However, myocardial injury itself affects postoperative mortality and significantly worsens the long-term prognosis and quality of treatment. This article reports the features of the etiopathogenetic mechanisms of cardiac complications during surgical care, as well as the multifactorial genesis of myocardial injury. The analysis of modern scientific literature on the diagnosis of myocardial damage is given. The need for early diagnosis of myocardial damage to create optimal management tactics for patients undergoing noncardiac interventions is demonstrated.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>миокардиальное повреждение</kwd><kwd>биомаркеры</kwd><kwd>некардиальная хирургия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>myocardial injury</kwd><kwd>biomarkers</kwd><kwd>non-cardiac surgery</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Smilowitz N.R., Gupta N., Guo Y., Berger J. Perioperative acute myocardial infarction associated with non-cardiac surgery. European Heart Journal . 2017. 38(31):2409-2417. DOI: 10.1093/eurheartj/ehx313</mixed-citation><mixed-citation xml:lang="en">Smilowitz N.R., Gupta N., Guo Y., Berger J. Perioperative acute myocardial infarction associated with non-cardiac surgery. European Heart Journal . 2017. 38(31):2409-2417. 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