kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2014-4-70-79kpccz-87Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESБИОЛОГИЧЕСКАЯ ИСКУССТВЕННАЯ ПЕЧЕНЬBIOLOGICAL ARTIFICIAL LIVERГригорьевЕ. В.GrigoryevE. V.ПлотниковГ. П.PlotnikovG. P.

ведущий научный сотрудник лаборатории критических состояний

Адрес для переписки:Г. П. Плотников, 650002, г. Кемерово, Сосновый бульвар, д. 6. Тел: +7 (3842) 64-33-08

leading research associate of critical conditions laboratory

Correspondence address:G. P. Plotnikov, 6, Sosnoviy blvd., 650002, Kemerovo. Tel.: +7 (3842) 64-33-08

Georg@kemcardio.ruШукевичД. Л.ShukevichD. L.ГоловкинА. С.GolovkinA. S.Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», КемеровоРоссияFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, KemerovoRussian Federation201402072015047079Copyright © Григорьев Е.В., Плотников Г.П., Шукевич Д.Л., Головкин А.С., 20152015Григорьев Е.В., Плотников Г.П., Шукевич Д.Л., Головкин А.С.Grigoryev E.V., Plotnikov G.P., Shukevich D.L., Golovkin A.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/87

Печеночная недостаточность является важнейшим жизнеугрожающим состоянием, ассоциирующимся с высочайшей степенью смертности. В обзоре приводятся основные направления по искусственному замещению функций печени, делается акцент на теоретических и практических возможностях создания биологической искусственной печени, разделов оптимизации: модификации мембран, выбора клеток для протезирования функции и создания благоприятной биологической среды для функционирования клеток.

Liver failure is a major life-threating condition associated with the highest degree of mortality. The review provides the basic directions of the artificial liver replacement, the emphasis on the theoretical and practical possibilities of creating a biological artificial liver: modification of membranes, cell selection and creating a favorable environment for the functioning of biological cells.

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The authors declare that there are no conflicts of interest present.