kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2021-10-3-90-102kpccz-952Research ArticleАНАЛИТИЧЕСКИЙ ОБЗОР. Сердечно-сосудистая хирургияREVIEWS. Cardiovascular surgeryСосудистые протезы с противомикробным покрытием: экспериментальные разработки и внедрение в клиническую практикуAntimicrobial vascular grafts: experimental development and implementation in clinical practicehttps://orcid.org/0000-0002-2500-2147КривкинаЕ. О.KrivkinaE. O.

Кривкина Евгения Олеговна - младший научный сотрудник лаборатории клеточных технологий отдела экспериментальной медицины.

Ул. Сосновый бульвар, 6, Кемерово, 650002

Krivkina Evgeniya O., Junior Researcher at the Laboratory of Cell Technologies, Department of Experimental Medicine.

6, Sosnoviy Blvd., Kemerovo, 650002

leonora92@mail.ruhttps://orcid.org/0000-0002-4146-3373МатвееваВ. Г.МatveevaV. G.

Матвеева Вера Геннадьевна, кандидат медицинских наук старший научный сотрудник лаборатории клеточных технологий отдела экспериментальной медицины.

Ул. Сосновый бульвар, 6, Кемерово, 650002

Matveeva Vera G., Ph.D., Senior Researcher at the Laboratory of Cell Technologies, Department of Experimental Medicine.

6, Sosnoviy Blvd., Kemerovo, 650002

https://orcid.org/0000-0002-8874-0788АнтоноваЛ. В.AntonovaL. V.

Антонова Лариса Валерьевна, доктор медицинских наук заведующая лабораторией клеточных технологий отдела экспериментальной медицины.

Ул. Сосновый бульвар, 6, Кемерово, 650002

Antonova Larisa V., Ph.D., Head of the Laboratory of Cell Technologies, Department of Experimental Medicine.

6, Sosnoviy Blvd., Kemerovo, 650002

Федеральное государственное бюджетное научное учреждение Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийРоссияFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular DiseasesRussian Federation20212409202110390102Copyright © Кривкина Е.О., Матвеева В.Г., Антонова Л.В., 20212021Кривкина Е.О., Матвеева В.Г., Антонова Л.В.Krivkina E.O., Мatveeva V.G., Antonova L.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/952

Цель. Одна из проблем сердечно-сосудистой хирургии - инфицирование сосудистого протеза, сопровождающееся тяжелыми осложнениями и высокими показателями смертности. Создание сосудистых протезов с антимикробным покрытием, способным защитить имплантат от инфицирования, является очень актуальным направлением. В настоящем обзоре освещены причины возникновения антибиотикорезистентности, описаны основные существующие направления создания сосудистых протезов с противомикробным покрытием, обозначены перспективы использования антимикробных пептидов и катионных амфифилов при создании антимикробного покрытия, к которому у патогенных микроорганизмов не развивается резистентности.

Prosthetic vascular graft infections, followed by severe complications and high mortality rates, remain one of the main issues in cardiovascular surgery. Therefore, the development of antimicrobial coating for vascular prostheses that is capable of preventing the infection is a very relevant field. This review outlines the main factors of development of antibiotic-resistant bacteria, the main directions in the development of vascular prostheses with an antimicrobial coating, and the prospects for the application of antimicrobial peptides and cationic amphiphiles as antimicrobial coating to develop an infection-resistant vascular prosthesis.

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The authors declare that there are no conflicts of interest present.