kpcczКомплексные проблемы сердечно-сосудистых заболеванийComplex Issues of Cardiovascular Diseases2306-12782587-9537Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”10.17802/2306-1278-2021-10-4-6-16kpccz-993Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ. КардиологияORIGINAL STUDIES. CardiologyРадиомические характеристики текстурных изменений эпикардиальной жировой ткани при атеросклеротическом поражении коронарных артерийRadiomic features of epicardial adipose tissue in coronary atherosclerosishttps://orcid.org/0000-0003-0772-6042ПоповЕ. В.PopovE. V.

Попов Евгений Викторович, клинический ординатор лаборатории радионуклидных методов исследования

ул. Киевская, 111а, Томск, 634012

Popov Evgeniy V., resident at Nuclear department

111a, St. Kievskaya, Tomsk, 634012

popov-yevgeniy92@mail.ruhttps://orcid.org/0000-0003-3169-0326АнашбаевЖ. Ж.AnashbaevZh. Zh.

Анашбаев Жанат Жуманалиевич, клинический ординатор лаборатории радионуклидных методов исследования

ул. Киевская, 111а, Томск, 634012

Anashbaev Zhanat Zh., resident at Nuclear department

111a, St. Kievskaya, Tomsk, 634012

https://orcid.org/0000-0002-1311-0378МальцеваА. Н.MaltsevaA. N.

Мальцева Алина Николаевна, клинический ординатор, лаборант-исследователь лаборатории радионуклидных методов исследования

ул. Киевская, 111а, Томск, 634012

Maltseva Alina N., resident and laboratory researcher at Nuclear department

111a, St. Kievskaya, Tomsk, 634012

https://orcid.org/0000-0003-2799-3260СазоноваС. И.SazonovaS. I.

Сазонова Светлана Ивановна, доктор медицинских наук ведущий научный сотрудник лаборатории радионуклидных методов исследования

ул. Киевская, 111а, Томск, 634012

Sazonova Svetlana I., PhD, leading researcher at Nuclear department

111a, St. Kievskaya, Tomsk, 634012

Научно-исследовательский институт кардиологии федерального государственного бюджетного научного учреждения «Томский национальный исследовательский медицинский центр Российской академии наук»РоссияCardiology Research Institute, Federal State Budgetary Scientific Institution “Tomsk National Research Medical Center of the Russian Academy of Sciences”Russian Federation202120122021104616Copyright © Попов Е.В., Анашбаев Ж.Ж., Мальцева А.Н., Сазонова С.И., 20212021Попов Е.В., Анашбаев Ж.Ж., Мальцева А.Н., Сазонова С.И.Popov E.V., Anashbaev Z.Z., Maltseva A.N., Sazonova S.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nii-kpssz.com/jour/article/view/993Цель

Цель. Исследовать ассоциацию радиомических характеристик эпикардиальной жировой ткани (ЭЖТ) на бесконтрастной компьютерной томографии (КТ) сердца с выраженностью обструктивного поражения коронарного русла и ишемии миокарда.

Материалы и методы

Материалы и методы. В исследование ретроспективно включены 68 пациентов с ишемической болезнью сердца (ИБС) (средний возраст 63,5±9,4 года; 45 мужчин и 23 женщины), а также 15 лиц (средний возраст 30±4,8 года; 14 мужчин и 1 женщина) без сердечно-сосудистых заболеваний, составившие группу контроля. Всем обследуемым выполнены мультиспиральная компьютерная коронароангиография, определение индекса коронарного кальция, нагрузочная перфузионная сцинтиграфия миокарда. На бесконтрастных КТ-изображениях сердца определяли радиомические характеристики ЭЖТ (текстурный анализ по градациям серого цвета) с помощью программного обеспечения 3D-Sliser и модуля SliserRadiomics (версия 4.10.2). Полученные показатели сравнивали между группами исследования и контроля, а также в подгруппах больных, разделенных в зависимости от степени обструкции коронарных артерий, размера дефекта перфузии и значения индекса коронарного кальция.

Результаты

Результаты. Сравнительный анализ радиомических показателей ЭЖТ у пациентов с ИБС и группы контроля показал наличие статистически значимых различий. В то же время корреляционный анализ в группе исследования не продемонстрировал связи между радиомическими показателями и размером дефекта перфузии, индексом коронарного кальция, степенью стеноза просвета коронарных артерий.

Заключение

Заключение. Текстурные характеристики ЭЖТ у пациентов с ИБС отличаются от таковых у лиц без сердечно-сосудистой патологии. В то же время данные показатели не ассоциированы с выраженностью обструктивного поражения коронарных артерий, значением индекса коронарного кальция, а также размером дефекта перфузии по данным сцинтиграфии.

Aim

Aim. To investigate the association of the radiomic characteristics of epicardial adipose tissue (EAT) on contrast-free computed tomography (CT) of the heart with the severity of obstructive coronary lesion and myocardial ischemia.

Methods

Methods. The study included 68 patients with coronary heart disease (mean age of 63.5±9.4, 45 men and 23 women), and 15 patients (mean age 30±4.8; 14 men and 1 woman) without cardiovascular disease as a control group. All the patients underwent multispiral computed coronary angiography, coronary calcium scores (CCS) determination and stress myocardial perfusion scintigraphy. Radiomic characteristics of EAT (texture analysis by gradations of gray color) were determined on non-contrast computer tomogram images of the heart using 3D-Sliser software and the SliserRadiomics module (version 4.10.2). The obtained indicators were compared between a control and under the study groups as well as between subgroups of patients divided according to the degree of obstruction of the coronary arteries, the size of the perfusion defect, and the value of the CCS.

Results

Results. The comparative analysis of radiomic indicators of EAT between patients with coronary artery disease and the control group showed the presence of statistically significant differences between them. At the same time, the correlation analysis in the study group did not reveal any correlations between the radiomic parameters and the size of the perfusion defect, CCS or degree of stenosis of the lumen of the coronary arteries.

Conclusion

Conclusion. The textural characteristics of EAT in patients with coronary heart disease differ from those in individuals without cardiovascular pathology. At the same time, these indicators are not associated with the severity of obstructive lesions of the coronary arteries, the value of the CCS, and the size of the perfusion defect according to scintigraphy.

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The authors declare that there are no conflicts of interest present.