FEATURES OF THE LIPID PROFILE AND ADIPOSE TISSUE IN PATIENTS WITH CAROTID ARTERY STENOSIS ON THE BACKGROUND OF CORONARY ARTERY DISEASE

Highlights

Intra-abdominal adipose tissue thickness (IAAT) was statistically significantly greater in patients with hypertriglyceridemia compared to patients with normal triglyceride levels. Linear regression analysis confirmed the following findings: the greater the thickness of IAAT and preperitoneal fat thickness (PFT), the higher the levels of triglycerides and very-low-density lipoproteins.

Abstract

Aim. To assess the lipid profile and distribution of adipose tissue (based on ultrasound parameters) and their role in the development of carotid artery stenosis in patients with coronary heart disease (CHD).

Methods. Ultrasound parameters of adipose tissue in 125 patients, diagnosed with coronary heart disease (CHD), were studied. The average age of the patients was 68 (61.0; 74.0) years old. The sample was represented predominantly by males (58.4%).

Results. It was determined that in patients who did not reach the target levels of triglycerides (TG), the thickness of the IAAT is 15 mm more than in patients with the adequate level of this indicator (p = 0.031). Subcutaneous adipose tissue (SAT) values also exceeded the values ​​in individuals with low HDL levels (p = 0.050), in contrast to patients with normal HDL. Linear regression analysis (after adjusting for gender and age) showed that the increase in IAAT thickness was associated with the increase in TG (b = 0.002, p = 0.028) and VLDL (b = 0.001, p = 0.023). It was also found that only 43.4% of the examined individuals received lipid-lowering therapy, and 17.3% received an adequate dose of statins (reached the target LDL values).

Conclusion. No statistically significant patterns were found between the achievement of lipid targets and the presence of carotid stenosis. An extremely low percentage of patients taking adequate lipid-lowering therapy (17.3%) was determined, and the proportion of the people with carotid stenosis who reached the target levels of total cholesterol was 58.4%, TG – 79.3%, HDL – 31.7%, LDL – 12.2%. The thickness of the IAAT is statistically significantly higher in individuals with hypertriglyceridemia, in contrast to patients with normal TG levels. The tendencies towards statistical significance of PFT indicators in individuals with hypertriglyceridemia, minimum and maximum SAT values, depending on the level of HDL, were determined. Linear regression analysis confirmed the data obtained: the higher the thickness of IAAT and PFT, the higher the levels of TG and VLDL.

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