Substantiation of protection of a neurovascular unit in the clinical model of cardiopulmonary bypass
https://doi.org/10.17802/2306-1278-2022-11-4-177-183
Abstract
This analytical review presents data on brain injury in surgical management of congenital heart disease. A brief description of mechanisms of brain injury and methods of its prevention are given, moreover, a clinical case applying such techniques is given. The neurovascular unit in vitro model and its advantages are presented. The protocol for modelling, the further application of the model, and the prospects of using it for studying intraoperative hypoxia and systemic inflammatory response on the patient`s brain are described.
About the Authors
A. A. Ivkin
Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”
Russian Federation
Russian Federation
Ivkin Artem A., MD, Research Assistant at the Laboratory of Anesthesiology and Resuscitation, Intensive Care and Pathophysiology of Critical Illness, Department of Cardiovascular Surgery
6, Sosnoviy Blvd., Kemerovo, 650002
E. V. Grigoriev
Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”
Russian Federation
Russian Federation
Grigoriev Evgeny V., PhD, Professor of the Russian Academy of Sciences, Deputy Director for Medicine and Scientific Work
6, Sosnoviy Blvd., Kemerovo, 650002
A. V. Morgun
Federal State Budgetary Educational Institution of Higher Education “Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University” of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Morgun Andrey V., PhD, Dean of the Faculty of Pediatrics, Head of the Department of Polyclinic Pediatrics and Propaedeutics of Childhood Diseases
1, Partizan Zheleznyak St., Krasnoyarsk, 660022
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Review
For citations:
Ivkin A.A., Grigoriev E.V., Morgun A.V. Substantiation of protection of a neurovascular unit in the clinical model of cardiopulmonary bypass. Complex Issues of Cardiovascular Diseases. 2022;11(4):177-183. (In Russ.) https://doi.org/10.17802/2306-1278-2022-11-4-177-183
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