Терапевтический ангиогенез как перспективное направление потенцирования ангиогенного действия аортокоронарного шунтирования

Основные положения. В обзоре систематизированы результаты экспериментальных и клинических исследований по влиянию аортокоронарного шунтирования на процессы ангиогенеза и перспективы применения производных пиримидинов в терапевтическом ангиогенезе.

Резюме. Аортокоронарное шунтирования выступает методом выбора при многососудистом поражении коронарного бассейна. Вместе с тем клиническая эффективность операции с течением времени снижается из-за прогрессирования атеросклероза в шунтах и нативных коронарных артериях. В этой связи представляют значительный научно-практический интерес раскрытие механизмов, влияющих на развитие микроциркуляторного русла при хирургической реваскуляризации миокарда, а также поиск фармакологических субстанций, способных стимулировать процесс ангиогенеза при проведении указанных операций с целью улучшения их непосредственных и отдаленных результатов. Статья представляет собой обзор экспериментальных и клинических исследований по влиянию аортокоронарного шунтирования на процессы ангиогенеза. Также в обзоре освещена роль производных пиримидинов в терапевтическом ангиогенезе при ишемической болезни сердца.

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