УДЛИНЕНИЕ ИНТЕРВАЛА QTC: РОЛЬ ПОЛИПРАГМАЗИИ, ЛЕКАРСТВЕННОЕ ВЗАИМОДЕЙСТВИЕ И РЕКОМЕНДАЦИИ ДЛЯ КЛИНИЧЕСКОЙ ПРАКТИКИ

Основные положения

Приобретенный синдром удлиненного интервала QT – редкое заболевание, но частота его встречаемости растет при полипрагмазии.

Резюме

Приобретенный синдром удлиненного интервала QT является редким заболеванием. Однако частота встречаемости удлиненного интервала QTc увеличивается у пациентов с полипрагмазией. Риск как удлинения интервала QTc, так и тахикардии типа «пируэт» возрастает экспоненциально при одновременном применении нескольких препаратов, удлиняющих интервал QTc. В статье показаны механизмы, лежащие в основе заболевания, и способы снижения риска потенциально фатальных аритмий.

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