MODERN ASPECTS OF PATHOPHYSIOLOGY AND DIAGNOSTICS OF HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION
Abstract
Highlights
- The pathophysiology of heart failure with preserved ejection fraction differs from heart failure with low ejection fraction.
- There are modern scales (HFA-PEFF and H2FPEF) that show the probability of heart failure with preserved ejection fraction.
- The sensitivity and specificity of both scales are insufficient. New research is needed.
Abstract
HFpEF is a common disease. It has a poor outlook due to high death rates and complex drug treatments. The article describes a modern view of HFpEF's pathophysiology. It focuses on the causes of myocardial remodeling. It also presents new algorithms for diagnosing HFpEF. The triggers for HFpEF are activation of the neuroendocrine system, low-level inflammation, and myocardial fibrosis. The causes and mechanisms of HFpEF are complex. So, researchers must revise current diagnostic methods. New risk scales, HFA-PEFF and H2FPEF, aim to identify HFpEF patients. Researchers are still studying their effectiveness. Using both imaging and lab tests gives a complete view of heart changes. This helps detect HFpEF with greater accuracy. The low agreement between these scales shows a need for more study of HFpEF patients, given their phenotyping. This may help develop simpler diagnostic algorithms.
About the Authors
Diana P. Paraskevova
A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russia
Russian Federation
Russian Federation
Cardiologist, Junior Researcher at the Department of Surgery for Older Children with CHD (Cardiac Surgery Department No. 6) of the Federal State Budgetary Institution “National Medical Research Center for Cardiovascular Surgery named after A.N. Bakulev” of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
Anton V. Minaev
A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russia
Russian Federation
Russian Federation
MD, Senior Researcher at the Department of Surgery for Older Children with CHD (Cardiac Surgery Department No. 6) of the Federal State Budgetary Institution “National Medical Research Center for Cardiovascular Surgery named after A.N. Bakulev” of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
Tatyana O. Astrakhantseva
A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russia
Russian Federation
Russian Federation
MD, Chief Researcher, Department of Surgery for Older Children with CHD (Cardiac Surgery Department No. 6), Federal State Budgetary Institution "A.N. Bakulev National Medical Research Center for Cardiovascular Surgery", Ministry of Health of the Russian Federation, Moscow, Russian Federation
Milena A. Keren
A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russia
Russian Federation
Russian Federation
MD, Senior Researcher, Department of Surgery for Combined Coronary and Main Artery Diseases (Cardiac Surgery Department No. 3), Federal State Budgetary Institution "A.N. Bakulev National Medical Research Center for Cardiovascular Surgery", Ministry of Health of the Russian Federation, Moscow, Russian Federation
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Supplementary files
Review
For citations:
Paraskevova D.P., Minaev A.V., Astrakhantseva T.O., Keren M.A. MODERN ASPECTS OF PATHOPHYSIOLOGY AND DIAGNOSTICS OF HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION. Complex Issues of Cardiovascular Diseases. (In Russ.)
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