ПАТОФИЗИОЛОГИЯ ИНФАРКТА МИОКАРДА: ИСТОРИЧЕСКИЕ ОЧЕРКИ И НОВЫЕ ГОРИЗОНТЫ

Основные положения

В аналитическом обзоре освещены основные патофизиологические механизмы развития инфаркта миокарда, включая сложные молекулярные процессы, приводящие к ишемии и некрозу сердечной мышцы. Исторически представления об этом состоянии прошли длительный путь – от первых описаний до современных методов диагностики и лечения, что значительно улучшило прогноз у пациентов с инфарктом миокарда.

Резюме

Понимание исторических аспектов и патофизиологии инфаркта миокарда имеет важное значение как для медицинских специалистов, так и пациентов. Знание механизмов развития инфаркта миокарда позволяет врачам более точно оценивать состояние пациента и выбирать оптимальные методы лечения, включая медикаментозную терапию и интервенционные процедуры. Проведен анализ научных статей, изданных в течение последнего десятилетия, с применением поисковых систем PubMed и eLibrary по ключевым словам: «атеросклероз», «история инфаркта миокарда», «патофизиология инфаркта миокарда», «ишемическая болезнь сердца», «патогенез атеротромбоза», «эндотелий», «воспаление». При отборе предпочтение отдавалось систематическим обзорам и метаанализам как источникам с наивысшим уровнем доказательности, а также рандомизированным контролируемым исследованиям, крупным когортным исследованиям и авторитетным клиническим рекомендациям.

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