INFLUENCE OF COMPOSITION AND CONCENTRATION OF BIODEGRADABLE POLYMERS ON STRUCTURE AND PHYSICO-MECHANICAL PROPERTIES OF ELECTROSPUN SCAFFOLDS
https://doi.org/10.17802/2306-1278-2016-2-30-38
Abstract
Purpose. To investigate the composition and concentration of the polymer solutions on structure and physico-mechanical properties of the electrospun scaffolds.
Materials and methods. We prepared electrospun scaffolds from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), polycaprolactone (PCL), and poly(D,L-lactide) (PLA) in concentrations of 6, 8, and 10 %. We investigated mechanical properties of the scaffolds, fiber diameter, and pore size.
Results. Concentration of the polymer solution significantly affected fiber diameter but not pore size. The optimal concentrations of PHBV, PLA, and PCL were 8–10 %. Use of PHBV/PLA composition lowered fiber diameter and pore size whilst PHBV/PCL composition increased elasticity of the scaffolds.
Conclusion. Composition and concentration of the polymer solutions significantly affects pore size, structure, and diameter of electrospun scaffolds, that influences physico-mechanical properties of the scaffolds.
About the Authors
D. K. Shishkova
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases. Kemerovo, Russia
Russian Federation
Russian Federation
M. V. Nasonova
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases. Kemerovo, Russia
Russian Federation
Russian Federation
Yu. I. Khodyrevskaya
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases. Kemerovo, Russia
Russian Federation
Russian Federation
A. L. Nemoykina
Federal State Budgetary Educational Institution of Higher Professional Education National Research Tomsk State University. Tomsk, Russia
Russian Federation
Russian Federation
N. V. Doronina
Federal State Institution of Science Institute of Biochemistry and Physiology of Microorganisms. Puschino, Russia
Russian Federation
Russian Federation
T. V. Glushkova
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases. Kemerovo, Russia
Russian Federation
Russian Federation
Yu. A. Kudryavtseva
Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases. Kemerovo, Russia
Russian Federation
Russian Federation
Address: 6, Sosnoviy blvd., Kemerovo, 650002, Russian Federation Tel. +7 (3842) 64-42-38
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Review
For citations:
Shishkova D.K., Nasonova M.V., Khodyrevskaya Yu.I., Nemoykina A.L., Doronina N.V., Glushkova T.V., Kudryavtseva Yu.A. INFLUENCE OF COMPOSITION AND CONCENTRATION OF BIODEGRADABLE POLYMERS ON STRUCTURE AND PHYSICO-MECHANICAL PROPERTIES OF ELECTROSPUN SCAFFOLDS. Complex Issues of Cardiovascular Diseases. 2016;(2):30-38. (In Russ.) https://doi.org/10.17802/2306-1278-2016-2-30-38
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