PREDICTORS OF CORONARY ATHEROSCLEROSIS AT MEN WITH THE METABOLIC SYNDROME
https://doi.org/10.17802/2306-1278-2017-6-3-84-92
Abstract
The purpose. Тo study set of the risk factors (RF) which are most significantly connected with risk of coronary atherosclerosis at men with the metabolic syndrome (MS).
Material and methods. The research included 82 men from MS by criteria of ВНОК, 2009, at the age of 39 - 73 years (56,42±7,3 years). Group 1 (n=40), patients with MS and a coronary heart disease: angina of pectoralis of IIIII f.cl. and a coronary atherosclerosis according to a coronaroangiography, group 2 (n=42), patients about the MS which don’t have a coronary heart disease: angina of pectoralis and symptoms of coronary atherosclerosis. In groups of comparison the analysis of the main and additional metabolic RF and by means of a method of logistic regression search of the most adverse set of RF bound to a coronary atherosclerosis at patients with MS was carried out.
Results. At patients of group 1 (n=40) higher rates of insulin (р<0,001), HOMA-IR index (р<0,001), Apo B (р<0,05), LPa (р<0,05), IL-6 (р<0,05), ФНО-α (р<0,05), CRP (р<0,05) and lower indicators of ApoA1 (р<0,05), apelin (р<0,001), than in group 2 (n=42) were defined. The predictors which are the most significantly connected with coronary atherosclerosis at patients with in steel MS: apelin, ApoB, insulin, IL-6, CRP and waist circumference.
Conclusion. The received set of predictors allows to choose more perspective and schemes of prophylaxis of cardiovascular complications at patients with MS are rational. The obtained data, are also valuable material for carrying out further scientific research with studying of a role of neurohormonal and pro-inflammatory activity of visceral adipose tissue in risk of development of a coronary heart disease in patients with MS.
About the Authors
D. M. Rudakova
Internal medicine, Altay State Medical University;
Altay regional hospita
Russian Federation
46, Malakhova st., Barnaul, 656055
Russian Federation
46, Malakhova st., Barnaul, 656055
N. G. Veselovskaya
Internal medicine, Altay State Medical University
Russian Federation
Barnaul
Russian Federation
Barnaul
G. A. Chumakova
Internal medicine, Altay State Medical University
Russian Federation
Barnaul
Russian Federation
Barnaul
E. S. Osipova
Internal medicine, Altay State Medical University
Russian Federation
Barnaul
Russian Federation
Barnaul
References
1. World Health Organization: Obesity and overweight fact sheet. http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed 04 Nov 2016.
2. Stevens G.A., Singh G.M., Lu Y., Danaei G., Lin J.K., Finucane M.M. et al. National, regional, and global trends in adult overweight and obesity prevalences. Popul Health Metr. 2012; 10: 22-26.
3. Квиткова Л.В., Бородкина Д.А., Груздева О.В. Метаболические признаки абдоминального ожирения у больных острым инфарктом миокарда с нормальной и повышенной массой тела. Проблемы эндокринологии. 2012; 4: 27-31. Kvitkova L.V., Borodkina D.A., Gruzdeva O.V. Metabolic symptoms of abdominal obesity at patients with an acute myocardial infarction with the normal and increased body weight. Endocrinology problems. 2012; 4: 27-31. [In Russ]
4. Mottillo S., Filion K.B., Genest J., Joseph L., Pilote .L, Poirier P., et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J AM Coll Cardiol. 2010; 56: 1113–1132.
5. Gami A.S., Witt B.J., Howard D.E., Erwin P.J., Gami L.A., Somers V.K. et al. Metabolic syndrome and risk of incident cardiovascular events and death. A systematic review and metaanalysis of longitudinal studies. J Am Coll Cardiol. 2007; 49: 403–414.
6. Janczura M., Bochenek G., Nowobilski R. The Relationship of Metabolic Syndrome with Stress, Coronary Heart Disease and Pulmonary Function - An Occupational Cohort-Based Study. PLoS One. 2015; 10(8): e0133750.
7. Moreira G.C., Cipullo J.P. Prevalence of Metabolic Syndrome: Association with Risk Factors and Cardiovascular Complications in an Urban Population. PLoS One. 2014; 9(9): e105056.
8. Fan J., Watanabe T. Inflammatory reactions in the pathogenesis of atherosclerosis. Journal of Atherosclerosis and Thrombosis. 2003;10 (2): 63–71.
9. Reilly M.P., Wolfe M.L., Rhodes T. Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis. Circulation. 2004; 110 (7): 803-809.
10. Веселовская Н.Г., Чумакова Г.А., Отт А.В., Гриценко О.В. Неинвазивный маркер инсулинорезистентности у пациентов с ожирением. Российский кардиологический журнал. 2013; 6(104): 28-32. Veselovskaya N.G., Chumakova G.A., Ott A.V., Gritsenko O.V. Noninvasive marker of insulin resistance at patients with obesity. Russian cardiological journal. 2013; 6(104): 28-32.
11. Ba H.J. Associations between serum apelin-12 levels and obesity-related markers in Chinese children. PLoS One. 2014;.9(1): e86577.
12. Castan-Laurell I., Vitkova M., Daviaud D. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Eur J Endocrinol 2008; 158(6): 905-910.
13. Harithy R. Serum Apelin-12 Concentration in Saudi Obese Middle-Aged Men. Life Science Journal. 2014; 11(10): 1113-1117.
14. Abeywardena M.Y., Leifert W.R., Warnes К.Е. Cardiovascular biology of interleukin-6. Current Pharmaceutical Design. 2009; 15(15):1809–1821.
15. Schuett H., Luchtefeld M., Grothusen C. How much is too much? Interleukin-6 and its signalling in atherosclerosis.Thrombosis and Haemostasis. 2009; 102(2): 215–222.
16. Zakynthinos E., Pappa N. Inflammatory biomarkers in coronary artery disease. J Cardiol 2009; 53(3): 317-33.
17. Zhou Y., Wang Y., Qiao S. Apelin: a potential marker of coronary artery stenosis and atherosclerotic plaque stability in ACS patients. Int Heart J. 2014; 55(3): 204-212.
18. Momiyama Y. Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis. Journal of Atherosclerosis and Thrombosis. 2010; 17(5): 460–467.
19. Ouchi N., Kihara S., Funahashi T. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 2003; 107(5): 671–674.
20. Алекперов Э.З., Наджафов Р.Н. Современные концепции о роли воспаления при атеросклерозе. Кардиология. 2010; 50(6): 88-91. Alekperov E.Z., Nadzharov R.N. Modern concepts about an inflammation role at an atherosclerosis. Cardiology. 2010; 50(6): 88-91.
21. Панюгова Е.В., Александрова Е.Н., Насонов Е.Л. Атеросклеротическое поражение сосудов у больных со стабильным течением ишемической болезни сердца: связь с С-реактивным белком. Кардиология. 2009; 49(4):40-45. Panugova E.V., Alexandrova E.N., Nasonov E.L. Atherosclerotic lesion of vessels at patients with the stable course of coronary heart disease: communication with C-reactive protein. Cardiology. 2009; 49(4): 40-45.
Review
For citations:
Rudakova D.M., Veselovskaya N.G., Chumakova G.A., Osipova E.S. PREDICTORS OF CORONARY ATHEROSCLEROSIS AT MEN WITH THE METABOLIC SYNDROME. Complex Issues of Cardiovascular Diseases. 2017;(3):84-92. (In Russ.) https://doi.org/10.17802/2306-1278-2017-6-3-84-92
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