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Комплексные проблемы сердечно-сосудистых заболеваний

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ОСНОВНЫЕ НАПРАВЛЕНИЯ МОДИФИКАЦИИ ПОВЕРХНОСТИ МЕТАЛЛИЧЕСКИХ ЭНДОВАСКУЛЯРНЫХ СТЕНТОВ В РЕШЕНИИ ПРОБЛЕМЫ РЕСТЕНОЗОВ (ОБЗОР, 2 ЧАСТЬ)

https://doi.org/10.17802/2306-1278-2017-6-3-131-142

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Аннотация

Вторая часть обзора посвящена вариантам модификации металлических стентов для ускорения эндотелизации in situ. Представлены разработки. направленные на захват эндотелиальных прогениторных клеток из кровотока с помощью специфических антител. Описаны возможности улучшения адгезии и интеграции эндотелиальных клеток на поверхности за счет формирования сайтов клеточного распознавания и имитация структур внеклеточного матрикса. Проанализированы различные способы физической и химической модификации, способствующие созданию условий для скорейшего формирования функционально состоятельного эндотелиального слоя на искусственных поверхностях. Определен круг проблем и ограничений в использовании каждого из методов.

Об авторах

А. И. Лотков
Институт физики прочности и материаловедения СО РАН; Томский государственный университет
Россия
Томск


В. Г. Матвеева
Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»
Россия
Кемерово


Л. В. Антонова
Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний»
Россия
650002, г. Кемерово, Сосновый бульвар, д. 6


О. А. Кашин
Институт физики прочности и материаловедения СО РАН
Россия
Томск


А. Н. Кудряшов
ООО «Ангиолайн»
Россия
Новосибирск


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Для цитирования:


Лотков А.И., Матвеева В.Г., Антонова Л.В., Кашин О.А., Кудряшов А.Н. ОСНОВНЫЕ НАПРАВЛЕНИЯ МОДИФИКАЦИИ ПОВЕРХНОСТИ МЕТАЛЛИЧЕСКИХ ЭНДОВАСКУЛЯРНЫХ СТЕНТОВ В РЕШЕНИИ ПРОБЛЕМЫ РЕСТЕНОЗОВ (ОБЗОР, 2 ЧАСТЬ). Комплексные проблемы сердечно-сосудистых заболеваний. 2017;(3):131-142. https://doi.org/10.17802/2306-1278-2017-6-3-131-142

For citation:


Lotkov A.I., Matveeva V.G., Antonova L.V., Kashin O.A., Kudryashov A.N. SURFACE MODIFICATION OF BARE-METAL STENTS FOR PREVENTING RESTENOSIS (PART 2). Complex Issues of Cardiovascular Diseases. 2017;(3):131-142. (In Russ.) https://doi.org/10.17802/2306-1278-2017-6-3-131-142

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