PROBLEM OF HEART SALVATION DURING REPERFUSION. OPIOID RECEPTOR AGONISTS AS A POSSIBLE SOLUTION
Аннотация
Ischaemia/reperfusion cardiac injury contributes to morbidity and mortality during percutaneous coronary intervention, heart surgery and transplantation. Even when the recanalization of an infarct-related coronary artery is carried out successfully, there is still a risk of death due to reperfusion injury. Numerous pharmacological interventions have been found in experiments on animals. However, the translation of these interventions to clinical practice has been disappointing. None of the drug treatment has been able to improve in-hospital mortality of patients with acute myocardial infarction. The search for pharmacological agents able to salvage myocardium during reperfusion continues. Opioid receptor (OR) agonists represent one of the promising group of drugs for treatment of patients with myocardial infarction. It has been found that µ-, δ- and κ-OR agonists are able to attenuate heart injury when administered before or at the beginning of reperfusion. However, what kind of OR receptors need to be activated in order to protect the heart during reperfusion and the precise mechanism of this effect have yet to be elucidated.
Об авторах
I. G. Khaliulin
School of Clinical Sciences, University of Bristol
Великобритания
7 Bristol Royal Infirmary, Upper Maudlin Street, Bristol, BS2 8HW
Великобритания
7 Bristol Royal Infirmary, Upper Maudlin Street, Bristol, BS2 8HW
L. N. Maslov
Cardiology Research Institute, Tomsk National Research Medical Centre
Россия
Tomsk
Россия
Tomsk
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Для цитирования:
Khaliulin I.G., Maslov L.N. PROBLEM OF HEART SALVATION DURING REPERFUSION. OPIOID RECEPTOR AGONISTS AS A POSSIBLE SOLUTION. Комплексные проблемы сердечно-сосудистых заболеваний. 2017;(3):150-154. https://doi.org/10.17802/2306-1278-2017-6-3-150-154
For citation:
Khaliulin I., Maslov L.N. PROBLEM OF HEART SALVATION DURING REPERFUSION. OPIOID RECEPTOR AGONISTS AS A POSSIBLE SOLUTION. Complex Issues of Cardiovascular Diseases. 2017;(3):150-154. https://doi.org/10.17802/2306-1278-2017-6-3-150-154
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