RELATIONSHIPS BETWEEN SMOKING, CORONARY ARTERY DISEASE AND CARDIOVASCULAR RISK FACTORS (ESSE-RF IN THE KEMEROVO REGION)

Aim. To determine the relationships between smoking, coronary artery disease (CAD) and cardiovascular risk factors in the open population of Western Siberia.

Methods. A sample of 1628 men and women aged 25 to 64 years was formed in the Kemerovo region as a part of the multicenter epidemiological study “Ep-idemiology of Cardiovascular Diseases and Their Risk Factors in the Russian Federation”. All patients were divided into three groups according to smoking status: non-smokers, ex-smokers and smokers. The following cardiovascular risk factors were analyzed: arterial hypertension, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, overweight, diabetes mellitus, low educational status, unemployment. The statistical data were processed using the logistic regression analysis. The results are presented as odds ratios (ORs) with 95% confidence intervals (CI).

Results. Smoking among women was associated with low educational status (OR 1.92; 1.31-2.80) and unemployment (OR 1.51; 1.01-1.09), whereas ex-smoking / smoking with hypertriglyceridemia (OR 1.47; 1.1-2.14) and low educational status (OR 1.49; 1.102.02). Smoking among men was associated with re duced prevalence of overweight (OR 0.61; 0.41-0.91), low educational status (OR 2.92; 1.99-4.27) and unem-ployment (OR 1.86; 1.12-3.10), whereas ex-smoking / smoking with low educational status (OR 2.49; 1.763.52), and unemployment (OR 1.61; 1.01-2.59), smoking cessation with overweight (OR = 2.32; 1.37-3.94) and low educational status (OR 1.93, 95% CI 1.27-2.94). After eliminating the joint effect of modifying cardiovascular risk factors, only smoking in men was associated with increased risk of coronary artery disease (OR, 1.94; 1,01-3,73).

Conclusion. The obtained associations between several cardiovascular risk factors are consistent with the recent Russian and foreign studies. The findings suggested smoking to be an independent risk factor for coronary artery disease as well as the factor associated with other cardiovascular risk factors.

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