CLINICAL SINGS AND SYMPTOMS OF POLYVASCULAR DISEASE IN CORONARY ARTERY DISEASE PATIENTS OF DIFFERENT AGE GROUPS

Aims. To perform comparative assessment of lesion pattern of the coronary and brachiocephalic arteries. To measure levels of matrix metalloproteinase-9 (MMP-9), relative telomere length and arterial stiffness in stable coronary artery disease patients of different age groups.

Methods. 106 male patients with stable coronary artery disease, functional class 1-3 were included in the study. All patients were assigned to two groups according to their age. Patients of younger age and middle-aged (n=59, 52 [46.5; 55] years) were included in Group 1, and 47 elderly patients (64 [62; 67] years; p<0.001) were included in Group 2. Clinical and demographic data, coronary angiography findings, metabolic parameters, ECHOCG findings, levels of MMP-9, relative telomere length and arterial stiffness were included in the analysis.

Results. Young and middle-aged patients commonly had obesity, elevated low density lipoproteins levels and triglycerides levels. Smokers prevailed in this group. According to coronary angiography, one vessel disease was commonly found in younger patients, whereas mul-tivessel disease in elder patients. However, there were no significant differences found in ECHO-CG parameters and atherosclerotic lessions of brachiocephalic arteries between the study groups. Levels of MMP-9 as an indirect marker of arterial stiffness were elevated in both study groups as well as cardio-ankle vascular index. Relative telomere length was similar in both groups.

Conclusion. Our data allow to assume vascular aging syndrome existence in young and middle age patients, and the severe course of coronary artery disease and ath-erosclerosis likelihood in these groups patients.

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