EPICARDIAL OBESITY AS ONE OF THE BASIC CRITERIA FOR METABOLICALLY UNHEALTHY OBESITY PHENOTYPE AND THE PREDICTOR OF SUBCLINICAL ATHEROSCLEROSIS
https://doi.org/10.17802/2306-1278-2018-7-1-21-28
Abstract
Aim. To assess the effect of epicardial obesity on the development of dyslipidemia and polyvascular subclinical atherosclerosis, and to assess the prognostic significance of various obesity criteria in the development of cardiovascular risk.
Methods. Male patients with arterial hypertension and without clinical symptoms of atherosclerosis of any localization and type 2 diabetes were included in the study. All the patients were enrolled into two groups, depending on the metabolic phenotypes of obesity assessed by epicardial fat thickness and body mass index. Both groups were comparable in waist circumference. All patients in both groups had abdominal obesity (AO≥94 cm). The study groups underwent a comparative assessment of parameters of lipid metabolism and levels of Apo-proteins. Coronary atherosclerosis was measured with multispiral computed tomography. Atherosclerotic lesions of brachiocephalic arteries were assessed by duplex scanning was performed. Epicardial fat thickness was measured by echocardiography.
Results. Significant relationships between epicardial obesity and the development of dyslipidemia and polyvascular subclinical atherosclerosis have been determined. Waist circumference and body mass index have low prognostic significance for developing cardiovascular risk.
Conclusion. Epicardial obesity significantly affects the development of subclinical atherosclerosis of the coronary and brachiocephalic arteries. The assessment of cardiovascular risk in patients with arterial hypertension and without other diagnosed cardiovascular diseases reported that it is necessary to measure epicardial fat thickness along with traditional risk factors. Epicardial fat thickness is considered to be a criterion for visceral obesity, contributing to the development of cardiometabolic disorders.
About the Authors
A. V. Ott
Altai State Medical University
Russian Federation
Russian Federation
Corresponding author: Ott Anna, address: Russian Federation, 656055, Barnaul, 46, Malakhova Street
G. A. Chumakova
Altai State Medical University
Russian Federation
Barnaul
Russian Federation
Barnaul
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For citations:
Ott A.V., Chumakova G.A. EPICARDIAL OBESITY AS ONE OF THE BASIC CRITERIA FOR METABOLICALLY UNHEALTHY OBESITY PHENOTYPE AND THE PREDICTOR OF SUBCLINICAL ATHEROSCLEROSIS. Complex Issues of Cardiovascular Diseases. 2018;7(1):21-28. (In Russ.) https://doi.org/10.17802/2306-1278-2018-7-1-21-28
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