NEW BIOMARKERS OF HEART FAILURE: DIAGNOSTIC AND PROGNOSTIC VALUE OF NT-proBNP AND INTERLEUKIN RECEPTOR FAMILY MEMBER ST2
https://doi.org/10.17802/2306-1278-2018-7-1-94-101
Abstract
The article discusses the use of new biomarkers for assessing the severity of the clinical course and the prognosis of chronic heart failure. In recent decades, prospective possibilities for using biomarkers as the part of early personalized diagnosis of cardiovascular disease have been actively studied to optimize the diagnosis process, patients’ prognosis and increase the effectiveness of therapy for chronic heart failure. New biomarkers are highly sensitive mediators for evaluation of pathogenetic mechanisms of the development and progression of chronic heart failure. Plasma levels of a new biomarker expressed by cardiomyocytes, fibroblasts and endothelial cells, a member of the IL-1 family of soluble isoform ST2 (sST2), which ligand is IL-33 cytokine, is of particular interest. Risk personification using NT-proBNP and ST2 biomarkers allows identifying themostvulnerablepatients for further monitoringand intensification of therapeutic interventions.
About the Authors
K. V. Kopeva
Federal State Budgetary Institution «Tomsk National Research Medical Centre, Russian Academy of Sciences» «Cardiology Research Institute»
Russian Federation
Tomsk
Russian Federation
Tomsk
E. V. Grakova
Federal State Budgetary Institution «Tomsk National Research Medical Centre, Russian Academy of Sciences» «Cardiology Research Institute»
Russian Federation
Corresponding author: Elena V. Grakova, address: Russian Federation, 634012, Tomsk, 111a, Kievskaya Street
Russian Federation
Corresponding author: Elena V. Grakova, address: Russian Federation, 634012, Tomsk, 111a, Kievskaya Street
A. T. Teplyakov
Federal State Budgetary Institution «Tomsk National Research Medical Centre, Russian Academy of Sciences» «Cardiology Research Institute»
Russian Federation
Tomsk
Russian Federation
Tomsk
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For citations:
Kopeva K.V., Grakova E.V., Teplyakov A.T. NEW BIOMARKERS OF HEART FAILURE: DIAGNOSTIC AND PROGNOSTIC VALUE OF NT-proBNP AND INTERLEUKIN RECEPTOR FAMILY MEMBER ST2. Complex Issues of Cardiovascular Diseases. 2018;7(1):94-101. (In Russ.) https://doi.org/10.17802/2306-1278-2018-7-1-94-101
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