Telomere length and cardiovascular diseases
https://doi.org/10.17802/2306-1278-2018-7-4S-101-107
Abstract
Human telomere length shortens with aging and limits the number of cell divisions (Hayflick limit). This phenomenon is believed to be an evolutionary compromise to prevent the risk of cancer. However, the shortening of telomeres can play an important role in the development of age-associated diseases in the modem society with significantly increased life expectancy and, particularly, cardiovascular diseases, causing 35% of deaths among the elderly. The review provides the latest data from the studies aimed at determining the role of telomeres in the risk of developing cardiovascular diseases and describing the factors affecting the telomere length as well as possible causes of genomic instability due to the damage of telomeric regions.
About the Authors
R. R. Salakhov
Federal State Budgetary Scientific Institution Tomsk National Research Medical Center, Russian Academy of Sciences, Research Institute of Medical Genetics; Siberian State Medical University
Russian Federation
Competing Interests: Нет конфликта интересов
Russian Federation
Salakhov Ramil R. - PhD, researcher at the Laboratory of Population Genetics, TNRMC RA S RIMG, Tomsk, Russian Federation; Associate Professor at the Department of Biochemistry and Molecular Biology, SSMU.
10, nab. R. Ushayki, 634000, Tomsk; 2, Moskovsky trakt, 634055, Tomsk
Competing Interests: Нет конфликта интересов
A. V. Ponasenko
Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Competing Interests: Нет конфликта интересов
Russian Federation
Ponasenko Anastasia V. - PhD, Head of the Laboratory of Genomic Medicine, Department of Experimental and Clinical Cardiology.
6, Sosnoviy Blvd., 650002, Kemerovo
Competing Interests: Нет конфликта интересов
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Review
For citations:
Salakhov R.R., Ponasenko A.V. Telomere length and cardiovascular diseases. Complex Issues of Cardiovascular Diseases. 2018;7(4S):101-107. (In Russ.) https://doi.org/10.17802/2306-1278-2018-7-4S-101-107
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