PHARMACOECONOMIC ANALYSIS OF ANTIHYPERTENSIVE DRUGS FOR OPTIMIZING BLOOD PRESSURE IN YOUNG ADULTS
https://doi.org/10.17802/2306-1278-2019-8-2-30-36
Abstract
Aim. To evaluate the pharmacoeconomic analysis of three antihypertensive drugs routinely used to optimize blood pressure in young adults.
Methods. 250 patients were recruited to the study and subdivided into three groups: Group 1 patients (n = 131) received monotherapy with angiotensin-converting enzyme inhibitor, ramipril; Group 2 and 3 patients (n = 119) received combination therapy with perindopril + amlodipine and ramipril + amlodipine.
Results. The group of patients receiving ramipril had the average daily dose of 10 mg, patients taking egipres received 5/10 mg daily, and patients receiving prestans took 5/5 mg daily. Thus, the cost of treatment with ramipril at the dose optimally reducing blood pressure remained the same, while the cost of treatment with prestans decreased up to 37400.00 RUB, and egipres up to 45218.00 RUB. 4.76% of patients who received these antihypertensive medicines experienced side effects, namely cough, dizziness, a sharp decrease in blood pressure, allergic dermatitis, nausea. The least rate of side effects occurred in patients who received perindopril, whereas the highest was recorded in the group of patients receiving ramipril (3.5% vs. 6.5%, respectively).
Conclusion. No significant differences found in the antihypertensive effects between three groups of drugs (ramipril, prestans, egipres). All three medicines included in this study effectively reduced blood pressure. However, prestans was associated with the least rate of side effects. Most side effects were short-term and of mild to moderate severity.
About the Authors
I. S. Kovrigin
Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetsky
Russian Federation
Russian Federation
PhD student at the Department of Outpatient Care and Family,
1, Partizana Zheleznyaka St., Krasnoyarsk, 660022
M. M. Petrova
Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetsky
Russian Federation
Russian Federation
PhD, Professor, Chairperson of the Department of Outpatient Care and Family Medicine,
1, Partizana Zheleznyaka St., Krasnoyarsk, 660022
D. S. Kaskaeva
Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetsky
Russian Federation
Russian Federation
PhD, Associate Professor at the Department of Outpatient Care and Family Medicine,
1, Partizana Zheleznyaka St., Krasnoyarsk, 660022
I. V. Romanova
Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetsky
Russian Federation
Russian Federation
PhD, Associate Professor at the Department of Outpatient Care and Family Medicine,
1, Partizana Zheleznyaka St., Krasnoyarsk, 660022
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Review
For citations:
Kovrigin I.S., Petrova M.M., Kaskaeva D.S., Romanova I.V. PHARMACOECONOMIC ANALYSIS OF ANTIHYPERTENSIVE DRUGS FOR OPTIMIZING BLOOD PRESSURE IN YOUNG ADULTS. Complex Issues of Cardiovascular Diseases. 2019;8(2):30-36. (In Russ.) https://doi.org/10.17802/2306-1278-2019-8-2-30-36
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