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CHALLENGES IN TREATING HEMODIALYSIS-DEPENDENT PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. A СLINICAL CASE

https://doi.org/10.17802/2306-1278-2019-8-2-135-142

Abstract

The clinical case reports a personalized expert approach to the management of a patient with myocardial infarction receiving programmed hemodialysis. The challenges facing by cardiologists with antiplatelet therapy, statin therapy, betablockers and renin-angiotensin-aldosterone system blockers as basic therapy have been discussed. The experience of performing coronary angiography with a limited dosage of the contrast agent followed by the stenting in the patient intolerant to unfractionated heparin is presented The complexity of post-puncture hemostasis before dialysis is highlighted. A particular attention has been paid to the existing difficulties in selecting rational loading doses of antiplatelet agents for these patients due to poor evidences on the elimination of clopidogrel metabolites from the blood flow.

About the Authors

D. Yu. Sedykh
Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases” ; State Budgetary Healthcare Institution of the Kemerovo Region “Kemerovo Regional Clinical Cardiology Dispensary n.a. Academician L.S. Barbarash”
Russian Federation

MD, PhD, researcher at Laboratory of Pathophysiology of Multivessel Coronary Artery Disease and Polyvascular Disease; cardiologist,

6, Sosnoviy Blvd, Kemerovo, 650002; 6, Sosnoviy Blvd, Kemerovo,  650002 



L. Yu. Chesnokova
State Budgetary Healthcare Institution of the Kemerovo Region “Kemerovo Regional Clinical Cardiology Dispensary n.a. Academician L.S. Barbarash”
Russian Federation

MD, PhD, Head of the Department of Myocardial Infarction, cardiologist,

6, Sosnoviy Blvd, Kemerovo,  650002



V. V. Kashtalap
Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases” ; Federal State Budgetary Educational Institution of Higher Education “Kemerovo State Medical University” of the Ministry of Healthcare of the Russian Federation
Russian Federation

MD, PhD, Head of the Laboratory of Pathophysiology of Multivessel Coronary Artery Disease and Polyvascular Disease; Associate Professor at the Department of Cardiology and Cardiovascular Surgery,

6, Sosnoviy Blvd, Kemerovo, 650002; 22a, Voroshilova St., Kemerovo, 650029



S. V. Kirilenko
Kemerovo branch of the Medical Private Institution of Additional Professional Education “Nefrosovet”
Russian Federation

MD, Head of the Department of Nephrology and Hemodialysis, 

22a, Building 1, Oktyabrsky Prospect, Kemerovo,  650066



O. L. Barbarash
Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases” ; Federal State Budgetary Educational Institution of Higher Education “Kemerovo State Medical University” of the Ministry of Healthcare of the Russian Federation
Russian Federation

PhD, Corresponding Member of the Russian Academy of Sciences, Director; Professor of the Department of Cardiology and Cardiovascular Surgery, 

6, Sosnoviy Blvd, Kemerovo, 650002; 22a, Voroshilova St., Kemerovo, 650029



References

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6. Jeong K.H., Cho J.H., Woo J.S., Kim J.B., Kim W.S., Lee T.W. et al. Platelet reactivity after receiving clopidogrel compared with ticagrelor in patients with kidney failure treated with hemodialysis: a randomized crossover study. Am. J. KidneyDis. 2015; 65 (6): 916–24. doi: 10.1053/j.ajkd.2014.11.023.

7. Shroff G.R., Herzog C.A. β -Blockers in dialysispatients: a nephrocardiology perspective. J. Am.Soc. Nephrol. 2015; 26 (4): 774–6. doi: 10.1681/ASN.2014080831

8. Barylski M., Nikfar S., Mikhailidis D.P., Toth P.P.,Salari P., Ray K.K. et al. Lipid and blood pressure meta-analysis collaboration group. Statins decrease all-cause mortality only in CKD patients not requiring dialysis therapy – a meta-analysis of 11 randomized controlled trials involving 21,295 participants. Pharmacol. Res. 2013; 72: 35–44. doi: 10.1016/j.phrs.2013.03.007

9. Drapkina O.M., Korneeva O.N. Statins in chronic kidney disease. Is there a variety of drugs? Cardiovascular Therapy and Prevention. 2015; 14 (6): 78–82 (in Russian).

10. Sarafidis P.A., Persu A., Agarwal R., Burnier M.,de Leeuw P., Ferro C. et al. Hypertension in dialysis patients: a consensus document by the European Renal and Cardiovascular Medicine (EURECA-m) working group of the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) and the Hypertension and the Kidney working group of the European Society of Hypertension (ESH). Nephrol. Dial. Transplant. 2017; 32 (4): 620–40. doi: 10.1093/ndt/gfw433.

11. Sedykh D.Y., Petrov G.P., Kashtalap V.V. Differences in adherence behaviour patterns in patients with primary and recurrent myocardial infarction. Complex Issues of Cardiovascular Diseases. 2018;7(4):15-25. https://doi.org/10.17802/2306-1278-2018-7-415-25 (In Russian.)


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For citations:


Sedykh D.Yu., Chesnokova L.Yu., Kashtalap V.V., Kirilenko S.V., Barbarash O.L. CHALLENGES IN TREATING HEMODIALYSIS-DEPENDENT PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. A СLINICAL CASE. Complex Issues of Cardiovascular Diseases. 2019;8(2):135-142. (In Russ.) https://doi.org/10.17802/2306-1278-2019-8-2-135-142

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ISSN 2306-1278 (Print)
ISSN 2587-9537 (Online)