THE ROLE OF AUTOANTIBODIES IN VARIOUS CELLULAR AND INTRACELLULAR CARDIAC STRUCTURES IN CHILDREN WITH HEART RHYTHM DISTURBANCES (A REVIEW)
https://doi.org/10.17802/2306-1278-2019-8-3-96-103
Abstract
This review discusses the role of autoimmune mechanisms in the development of heart rhythm disturbances and conduction disorders of various origins. The search was performed using PubMed, Medline and Google Scholar. Specific cardiovascular diseases (dilated cardiomyopathy, myocarditis, conduction disorders) developing in childhood and adolescence are associated with an increase in titer to intracellular proteins specific to myocardiocytes and cells of the cardiac conduction system. Candidate autoantibodies markers for autoimmune response have been selected. The rationale for analyzing the immune status of heart rhythm disturbances in children and adolescents has been provided.
About the Authors
I. V. Plotnikova
Cardiology Research Institute, Federal State Budgetary Scientific Institution “Tomsk National Research Medical Center of the Russian Academy of Sciences”;
Siberian State Medical University
Russian Federation
Russian Federation
Plotnikova Irina V., PhD, Head of the Department of Pediatric Cardiology, Cardiology Research Institute, Federal State Budgetary Scientific Institution “Tomsk National Research Medical Center of the Russian Academy of Sciences”, Tomsk, Russian Federation; senior lecturer at the Cardiology Department, Siberian State Medical University
111a, Kievskaya St., Tomsk, 634012,
2, Moskovsky trakt, Tomsk, 634055
L. I. Svintsova
Cardiology Research Institute, Federal State Budgetary Scientific Institution “Tomsk National Research Medical Center of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Svintsova Liliya I., PhD, leading researcher at the Department of Pediatric Cardiology
111a, Kievskaya St., Tomsk, 634012
O. Yu. Dzhaffarova
Cardiology Research Institute, Federal State Budgetary Scientific Institution “Tomsk National Research Medical Center of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Dzhaffarova Olga Y., PhD, senior researcher at the Department of Pediatric Cardiology
111a, Kievskaya St., Tomsk, 634012
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Review
For citations:
Plotnikova I.V., Svintsova L.I., Dzhaffarova O.Yu. THE ROLE OF AUTOANTIBODIES IN VARIOUS CELLULAR AND INTRACELLULAR CARDIAC STRUCTURES IN CHILDREN WITH HEART RHYTHM DISTURBANCES (A REVIEW). Complex Issues of Cardiovascular Diseases. 2019;8(3):96-103. (In Russ.) https://doi.org/10.17802/2306-1278-2019-8-3-96-103
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