THE INFLUENCE OF THROMBOPHILIC STATES FOR A PULMONARY EMBOLISM AND EFFICACY OF THROMBOSIS THERAPY
https://doi.org/10.17802/2306-1278-2012-1-40-42
Abstract
Purpose. This study was aimed at examining the infl uence of thrombophilic conditions on pulmonary embolism (PE) and the effi cacy of thrombolytic therapy. Materials and methods. The effects of haemostatic disorders on the frequency of recurrent PE, phlebothrombosis and inferior vena cava thrombosis were studied in 70 patients with acute massive PE. Results. Hematogenic thrombophilia was detected in 25,7 % of patients. It was found that thrombosis and embolism in the vena cava fi lter were observed more frequently in patients with hematogenic thrombophilia than in patients with pulmonary embolism of unknown etiology. Conclusions. It was proved that differentiated treatment of hematogenic thrombophilias can signifi cantly reduce the risk of recurrent thrombotic episodes in patients with acute pulmonary embolism.
About the Authors
A. N. Shilova
Academician E. N. Meshalkin State Research Institute of Circulation Pathology, Novosibirsk
Russian Federation
Russian Federation
A. A. Karpenko
Academician E. N. Meshalkin State Research Institute of Circulation Pathology, Novosibirsk
Russian Federation
Russian Federation
N. A. Karmadonova
Academician E. N. Meshalkin State Research Institute of Circulation Pathology, Novosibirsk
Russian Federation
Russian Federation
M. V. Starosotskaya
Academician E. N. Meshalkin State Research Institute of Circulation Pathology, Novosibirsk
Russian Federation
Russian Federation
References
1. Баркаган З. С. Клинико-диагностические варианты, номенклатура и основы диагностики гематогенных тромбофилий // Проблемы гематологии и переливания крови. 1996. № 3. С. 5–15.
2. Баркаган З. С., Костюченко Г. И., Котовщикова Е. Ф. Гипергомоцистеинемия как самостоятельный фактор риска поражения и тромбирования кровеносных сосудов // Патология кровообращения и кардиохирургия. 2002. № 1. С. 65–71.
3. Воробьев А. И. Руководство по гематологии. М.: Ньюдиамед, 2005. Т. 3. 467 с.
4. Bauer K. A. Management of thrombophilia // J. Thrombos. Haemost. 2003. Vol. 1, № 7. P. 1429–1434.
5. Greaves M. Antiphospholipid antibodies and thrombosis // Lancet. 1999. Vol. 353. С. 1348–1353.
6. Heit J. A. The epidemiology of venous thromboembolism in the community // Arterioscler. Thromb. Vasc Biol. 2008. Mar. Vol. 28(3). Р. 370–372.
7. High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism / R. A. Kraaÿenhagen, P. S. Anker, M. M. Koopman et al. // Thromb. Haemost. 2000. Vol. 83. Р. 5–9.
8. Svensson P. J., Dahlbäck B. Resistance to activated protein C as a basis for venous thrombosis // N. Engl. J. Med. 1994. Vol. 330. Р. 517–522
Review
For citations:
Shilova A.N., Karpenko A.A., Karmadonova N.A., Starosotskaya M.V. THE INFLUENCE OF THROMBOPHILIC STATES FOR A PULMONARY EMBOLISM AND EFFICACY OF THROMBOSIS THERAPY. Complex Issues of Cardiovascular Diseases. 2012;(1):40-42. (In Russ.) https://doi.org/10.17802/2306-1278-2012-1-40-42
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