RESORPTION RATE OF POLYHYDROXYALKANOATEBASED SCAFFOLDS AND SCAFFOLDS WITH MULTIPOTENT MESENCHYMAL STROMAL CELLS
https://doi.org/10.17802/2306-1278-2015-1-39-45
Abstract
The article presents the findings of histological analysis of local tissue response to subcutaneous implantation of polyhydroxyalkanoatebased scaffolds and scaffolds with multipotent mesenchymal stromal cells. There were no rejection and acute inflammatory response of the implanted biopolymeric materials. The connective tissue capsule has formed around the implanted materials. Active cell infiltration of the implanted material and its vascularization have been observed. The implanted scaffolds undergo slow biodegradation. The presence of multipotent mesenchymal stromal cells on the scaffold surface slows down the resorption rate of the polymer.
About the Authors
M. V. Nasonova
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
For correspondence:Nasonova Marina Address: 6, Sosnoviy blvd., Kemerovo, 650002, Russian Federation Tel. 8 (3842) 64-42-38 E-mail: nanomv@kemcardio.ru
I. V. Antonova
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
V. G. Matveeva
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
N. V. Doronina
Skryabin Institute of Biochemistry and Physiology of Microorganisms, RAS, Puschino, Moscow reg.
Russian Federation
Russian Federation
V. A. Ezhov
Skryabin Institute of Biochemistry and Physiology of Microorganisms, RAS, Puschino, Moscow reg.
Russian Federation
Russian Federation
A. Yu. Burago
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
T. V. Glushkova
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
Yu. A. Kudryavtseva
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
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Review
For citations:
Nasonova M.V., Antonova I.V., Matveeva V.G., Doronina N.V., Ezhov V.A., Burago A.Yu., Glushkova T.V., Kudryavtseva Yu.A. RESORPTION RATE OF POLYHYDROXYALKANOATEBASED SCAFFOLDS AND SCAFFOLDS WITH MULTIPOTENT MESENCHYMAL STROMAL CELLS. Complex Issues of Cardiovascular Diseases. 2015;(1):39-45. (In Russ.) https://doi.org/10.17802/2306-1278-2015-1-39-45
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