ISCHEMIC POSTCONDITIONING OF HEART. ANALYSIS OF EXPERIMENTAL AND CLINICAL DATA
https://doi.org/10.17802/2306-1278-2015-3-37-46
Abstract
Published data on the impact of the experimental atherosclerosis on the infarct-limiting effect of ischemic postconditioning (IPost) are controversial. The reviewed data indicate that aging eliminates or reduces the infarct-limiting effect of postconditioning but does not affect the antiarrhythmic effect of IPost. Most of the experimental data reported that streptozotocin-induced diabetes removes the infarct-limiting effect of IPost. Regarding the second type of diabetes, information is contradictory: some authors argue that this diabetes completely eliminates the cardioprotective effect of IPost, others say that it only weakens but does not eliminate the infarct-limiting effect of IPost. Postconditioning in rats with high blood pressure prevents the appearance of reperfusion contractile dysfunction of the heart and provides the infarct-limiting effect. Cardiac hypertrophy, post-infarction remodeling and dilated cardiomyopathy have no effect on the infarct-reducing and inotropic effect of postconditioning. The majority of publications indicates that IPost enhances the inotropic and cardioprotective effect of cardioplegia. Data on the effect of postconditioning on the tolerance of the human heart to ischemia/reperfusion are limited and do not allow to make an unambiguous conclusion about whether IPost prevents reperfusion myocardial injury in cardiac patients.
About the Authors
Leonid N. Maslov
Federal State Budgetary Scientific Research Institute for Cardiology
Russian Federation
111A, Kievskaya st., Tomsk, 634012
Russian Federation
111A, Kievskaya st., Tomsk, 634012
I. G. Khaliulin
University of Bristol
United Kingdom
Bristol
United Kingdom
Bristol
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Review
For citations:
Maslov L.N., Khaliulin I.G. ISCHEMIC POSTCONDITIONING OF HEART. ANALYSIS OF EXPERIMENTAL AND CLINICAL DATA. Complex Issues of Cardiovascular Diseases. 2015;(3):37-46. (In Russ.) https://doi.org/10.17802/2306-1278-2015-3-37-46
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