AGE-RELATED FEATURES OF CORRELATION BETWEEN CARDIO-ANKLE VASCULAR INDEX AND FREQUENCY OF DETECTION OF CAROTID ATHEROSCLEROSIS IN GENERAL POPULATION OF WORKING AGE

Highlights

• There is an independent correlation between the cardio-ankle vascular index and the presence of atherosclerotic plaques in the carotid arteries in the working-age male population.
• In the presence of atherosclerotic plaques cardio-ankle vascular index values are higher at any age.
• The chances of detecting atherosclerotic plaques depended on the values of the cardio-ankle vascular index at a relatively young age. At an older age detection of atherosclerotic plaques did not depend on the index as much.
• The value of the cardio-ankle vascular index ≥ 6.9 is associated with a 7-fold increase in the chances of detecting atherosclerotic plaques in men aged 35-44 years.

Aim. To study age-specific relationship between the cardio-ankle vascular index (CAVI) and the presence of carotid atherosclerotic plaques (CAP) in the general population.

Methods. The study included 1 380 people from representative sample of general population (participants of the ESSE-RF study), aged 25–64 years, who underwent cardiac screening, volumetric sphygmography, and carotid ultrasonography. Correlation, linear and logistic regression analyzes were used to analyze relationships.

Results. The odds of detecting CAP depended significantly on CAVI in men and women: OR = 2.51 and 1.83 (both p < 0.001). After adjustment for age, systolic blood pressure and body mass index, the correlation was present in men only: OR = 1.30 (p = 0.017). The association was greatest at the age of 35–44 years, declined thereafter and was not observed after 55 years. CAVI​​ ≥ 6.9 was associated with a 7-fold increase in the odds of detecting CAP in men aged 35–44 years. Regardless of gender, CAVI values were high in case of ​CAP presence (both p < 0.001). After adjustments, the association remained only in men (p = 0.007). Dependence of CAVI on CAP presence did not vary significantly with age.

Conclusion. Study results revealed an independent correlation between CAVI and carotid plaques in the male population. CAP and high CAVI were present at any age. The chances of detecting CAP depended mostly on CAVI at a relatively young age (35–44 years). At an older age detection of CAP did not depend on CAVI as much. The data obtained indicate the possible contribution of vascular stiffness to development of early atherosclerosis.

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