Preview

Complex Issues of Cardiovascular Diseases

Advanced search

CLINICAL CASE OF AORTIC STENOSIS IN A PREGNANT PATIENT: IN SEARCH OF THE BEST SOLUTION

https://doi.org/10.17802/2306-1278-2025-14-1-159-168

Abstract

Highlights

Pathology of the aortic valve and aorta occupies a special place among extragenital pathology and is accompanied by high risks of complications, maternal and infant mortality in both the perinatal and intranatal periods. There are various ways to correct this pathology: surgical and transcatheter replacement of the aortic valve, and balloon valvuloplasty. However, there is no unified opinion regarding the preferable methods and timing of surgical correction of aortic stenosis in a pregnant woman, and all available data, due to the lack of large randomized trials and registries, are based on the opinion of experts and reports from centers.

 

 

Abstract

The article describes a rare case of transcatheter aortic valve implantation in a pregnant patient with severe aortic stenosis. The research methods included anamnestic analysis, ultrasound examination and computed tomography. Specialists used transcatheter implantation to treat the disease. Due to the rarity of the disease, the high risks of both maternal and infant mortality, and the lack of recommendations in the literature regarding the management of this category of patients based on large randomized trials, we present our own experience of a rare case of transcatheter aortic valve implantation in a pregnant patient.

About the Authors

Lucine L. Sarkisyan
Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation
Russian Federation

2nd year Resident (“Cardiology” specialty), Department of Therapy No. 1, Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnodar, Russian Federation



Sofiya V. Kruchinova
Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation; State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region
Russian Federation

PhD, Assistant at the Department of Therapy No. 1, Faculty of Advanced Training and Professional Retraining of Specialists, Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnodar, Russian Federation; Cardiologist at the Cardiology Department No. 2, State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region, Krasnodar, Russian Federation



Kirill A. Lashevich
State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region
Russian Federation

Specialist at the Department of Image-guided Surgical Methods of Diagnosis and Treatment, State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region, Krasnodar, Russian Federation



Sergei V. Meingart
Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation; State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region
Russian Federation

Assistant at the Department of Cardiac Surgery and Cardiology, Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnodar, Russian Federation; Specialist at the Department of Image-guided Surgical Methods of Diagnosis and Treatment, State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region, Krasnodar, Russian Federation



Alim M. Namitokov
Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation; State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region
Russian Federation

PhD, Assistant at the Department of Therapy No. 1, Faculty of Advanced Training and Professional Retraining of Specialists, Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnodar, Russian Federation; Head of the Cardiology Department No. 2, State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region, Krasnodar, Russian Federation



Alexey N. Fedorchenko
State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region
Russian Federation

PhD, Head of the Department of Image-guided Surgical Methods of Diagnosis and Treatment, State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region, Krasnodar, Russian Federation



Elena D. Kosmacheva
Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation; State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region
Russian Federation

PhD, Professor, Head of the Department of Therapy No. 1, Faculty of Advanced Training and Professional Retraining of Specialists, Federal State Budgetary Educational Institution of Higher Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation, Krasnodar, Russian Federation; Deputy Chief Physician for Medical Work, State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region, Krasnodar, Russian Federation



Vladimir A. Porkhanov
State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region
Russian Federation

PhD, Professor, Member of the Russian Academy of Sciences, Chief Physician, State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky” of the Ministry of Healthcare of the Krasnodar Region, Krasnodar, Russian Federation



References

1. Regitz-Zagrosek V., Roos-Hesselink J.W., Bauersachs J., Blomström-Lundqvist C., Cífková R., De Bonis M., Iung B., Johnson M.R., Kintscher U., Kranke P., Lang I.M., Morais J., Pieper P.G., Presbitero P., Price S., Rosano G.M.C., Seeland U., Simoncini T., Swan L., Warnes C.A.; ESC Scientific Document Group. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J. 2018;39(34):3165-3241. doi: 10.1093/eurheartj/ehy340.

2. Shapiro H., Alshawabkeh L. Valvular Heart Disease in Pregnancy. Methodist Debakey Cardiovasc J. 2024;20(2):13-23. doi: 10.14797/mdcvj.1323.

3. Van Hagen I.M., Boersma E., Johnson M.R., Thorne S.A., Parsonage W.A., Escribano Subías P..,Leśniak-Sobelga A., Irtyuga O., Sorour K.A., Taha N., Maggioni A.P., Hall R., Roos-Hesselink J.W.; ROPAC investigators and EORP team. Global cardiac risk assessment in the Registry Of Pregnancy And Cardiac disease: results of a registry from the European Society of Cardiology. Eur J Heart Fail. 2016;18(5):523-33. doi: 10.1002/ejhf.501.

4. Hoover E., Corlin T., Lohr J., Sabol B., Yamamura Y., Jacobs K., March S.K., Gorbaty B., Raveendran G. TAVR Beyond Fetal Viability: An Alternative to Preterm Delivery in Symptomatic Severe Aortic Stenosis. JACC Case Rep. 2023;27:102104. doi: 10.1016/j.jaccas.2023.102104.

5. Lima N.A., de Castro R.L.Jr., Huffman C., Diaz M., Lima C.C.V., Schauer M., Linares S.T., Melgar T.A. Hospital admissions for aortic stenosis in pregnancy in the United States - a thirteen year analysis. Am J Cardiovasc Dis. 2020;10(4):398-404.

6. Okorokov A. N. Diagnostics of diseases of internal organs: Vol. 9. Diagnostics of heart and vascular diseases. Moscow: Medicinskaja literatura, 2005. (in Russian)

7. Yagel O., Alter R., Nissan B., Zwas D.R., Rosenbloom J.I., Eyal O., Golomb M., Planer D., Elbaz-Greener G. A Pregnant Woman With Severe Symptomatic Aortic Stenosis: How Should We Treat? JACC Case Rep. 2024;29(3):102205. doi: 10.1016/j.jaccas.2023.102205.

8. John A.S., Gurley F., Schaff H.V., Warnes C.A., Phillips S.D., Arendt K.W., Abel M.D., Rose C.H., Connolly H.M. Cardiopulmonary bypass during pregnancy. Ann Thorac Surg. 2011;91(4):1191-6. doi: 10.1016/j.athoracsur.2010.11.037..

9. Sikka P., Bansal V., Mahajan S., Aggarwal P., Naganur S.H. Simultaneous Cesarean Section and Maternal Cardiac Surgery: Outcomes and Feasibility from a Tertiary Care Hospital in India. Braz J Cardiovasc Surg. 2023;38(5):e20220335. doi: 10.21470/1678-9741-2022-0335.

10. Chengode S., Shabadi R.V., Rao R.N., Alkemyani N., Alsabti H. Perioperative management of transcatheter, aortic and mitral, double valve-in-valve implantation during pregnancy through left ventricular apical approach. Ann Card Anaesth. 2018;21(2):185-188. doi: 10.4103/aca.ACA_157_17.

11. Lameijer H., van Slooten Y.J., Jongbloed M.R.M., Oudijk M.A., Kampman M.A.M., van Dijk A.P., Post M.C., Mulder B.J., Sollie K.M., van Veldhuisen D.J., Ebels T., van Melle J.P., Pieper P.G. Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease. Int J Cardiol. 2018;268:106-112. doi: 10.1016/j.ijcard.2018.05.038.

12. Yap S.C., Drenthen W., Pieper P.G., Moons P., Mulder B.J., Mostert B., Vliegen H.W., van Dijk A.P., Meijboom F.J., Steegers E.A., Roos-Hesselink J.W.; ZAHARA investigators.Risk of complications during pregnancy in women with congenital aortic stenosis. Int J Cardiol. 2008;126(2):240-6. doi: 10.1016/j.ijcard.2007.03.134

13. Berry N., Sawlani N., Economy K., Shook D., Nyman C., Singh M.N., Pelletier M., Sobieszczyk P., Kaneko T., Shah P. Transcatheter Aortic Valve Replacement for Bioprosthetic Aortic Stenosis in Pregnancy. JACC Cardiovasc Interv. 2018;11(19):e161-e162. doi: 10.1016/j.jcin.2018.07.046.

14. Herbert K.A., Sheppard S.M. Not Your Typical Dyspnea of Pregnancy: A Case Report of Transcatheter Valve-in-Valve Replacement During Pregnancy. A A Pract. 2019;12(6):202-204. doi: 10.1213/XAA.0000000000000884.


Supplementary files

Review

For citations:


Sarkisyan L.L., Kruchinova S.V., Lashevich K.A., Meingart S.V., Namitokov A.M., Fedorchenko A.N., Kosmacheva E.D., Porkhanov V.A. CLINICAL CASE OF AORTIC STENOSIS IN A PREGNANT PATIENT: IN SEARCH OF THE BEST SOLUTION. Complex Issues of Cardiovascular Diseases. 2025;14(1):159-168. (In Russ.) https://doi.org/10.17802/2306-1278-2025-14-1-159-168

Views: 220


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2306-1278 (Print)
ISSN 2587-9537 (Online)